Association between vitamin D receptor Fokl polymorphism and serum parathyroid hormone level in patients with chronic renal failure

Journal of Endocrinological Investigation

Volumn 28, Issue 4, 2005, Pages 117-121

  Gago, E Vigo ^a   Cadarso Suarez C ^a   Perez Fernandez, R ^a   Burgos, R Romero ^a   Mugica, J Devesa ^a   Iglesias, C Segura ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Fokl polymorphism; Hyperparathyroidism; Parathyroid hormone; Population study; VDR polymorphism; Vitamin D receptor

Indexed keywords

PARATHYROID HORMONE; RESTRICTION ENDONUCLEASE; VITAMIN D RECEPTOR; CALCIFEDIOL; CALCITRIOL RECEPTOR; CALCIUM; ENDODEOXYRIBONUCLEASE FOKI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CHRONIC KIDNEY FAILURE; CODON; EXON; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERPARATHYROIDISM; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; POLYMERASE CHAIN REACTION; RESTRICTION SITE; BLOOD; DRUG EFFECT; GENETICS; MIDDLE AGED;

CALCIFEDIOL; CALCIUM; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PARATHYROID HORMONE; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL;

EID: 20444503947     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03345353     Document Type: Article

References (23)

1. De Luca HF. The metabolism and functions of vitamin D. Adv Exp Med Biol 1986, 196: 361-75.
2. Arnold A, Shattuck TM, Mallya SM, et al. Molecular pathogenesis of primary hyperparathyroidism. J Bone Miner Res 2002, 17 (Suppl2): N30-6.
3. Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature 1994, 367: 284-7.
4. Nagaba Y, Heishi M, Tazawa H, Tsukamoto Y, Kobayashi Y. Vitamin D receptor gene polymorphisms affect secondary hyperparathyroidism in hemodialyzed patients. Am J Kidney Dis 1998, 32: 464-9.
5. Carling T, Kindmark A, Hellman P, Holmberg L, Akerstrom G, Rastad J. Vitamin D receptor alleles b, a, and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1. Biochem Biophys Res Commun 1997, 231: 329-32.
6. Carling T, Ridefelt P, Hellman P, Rastad J, Akerstrom G. Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism. J Clin Endocrinol Metab 1997, 82: 1772-5.
7. Marco MP, Martinez I, Amoedo ML, et al. Vitamin D receptor genotype influences parathyroid hormone and calcitriol levels in predialysis patients. Kidney Int 1999, 56: 1349-53.
8. Yokoyama K, Shigematsu T, Tsukada T, et al. Apal polymorphism in the vitamin D receptor gene may affect the parathyroid response in Japanese with end-stage renal disease. Kidney Int 1998, 53: 454-8.
9. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feldman D. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res 1996, 11: 1850-5.
10. Harris S, Eccleshall TR, Gross C, Dawson-Hughes B, Feldman D. The vitamin D receptor start codon polymorphism (Fokl) and bone mineral density in premenopausal American black and white women. J Bone Miner Res 1997, 12: 1043-8.
11. Arai H, Miyamoto KI, Taketami Y, et al. Vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 1997, 12: 915-21.
12. Kanan RM, Varanasi SS, Francis RM, Parker L, Datta HK. Vitamin D receptor gene start codon polymorphism (Fokl) and bone mineral density in healthy male subjects. Clin Endocrinol (Oxf) 2000, 53: 93-8.
13. Correa P, Rastad J, Schwarz P, et al. The vitamin D receptor (VDR) start codon polymorphism in primary hyperparathyroidism and parathyroid VDR messenger ribonucleic acid levels. J Clin Endocrinol Metab 1999, 84: 1690-4.
14. Vigo E, Salas A, Pérez-Fernández R, Segura C. Analysis of the vitamin D receptor Fokl polymorphism. J Endocrinol Invest 2004, 27: 158-62.
15. Silver J, Yalcindag C, Sela-Brown A, Kilav R, Naveh-Many T. Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. Kidney Int 1999, 56: S2-7.
16. Demay MB, Kiernan MS, DeLuca HF, Kronenberg HM. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 1992, 89: 8097-101.
17. Silver J, Kilav R, Naveh-Many T. Mechanisms of secondary hyperparathyroidism. Am J Physiol Renal Physiol 2002, 283: F36776.
18. Sosa M, Torres A, Martin N, Salido E, et al. The distribution of two different vitamin D receptor polymorphisms (Bsml and start codon) in primary hyperparathyroidism. J Intern Med 2000, 247: 124-30.
19. Alvarez-Hernández D, Naves M, Santamaría I, Menarguez J, Torregrosa V, Cannata J. Response of parathyroid glands to calcitriol in culture: Is this response mediated by the genetic polymorphisms in vitamin D receptor? Kidney Int Suppl 2003, 85: S19-22.
20. Korkor A. Reduce binding of [3H]1,25-dihydroxyvitami D3 in the parathyroid glands of patients with renal failure. N Engl J Med 1987, 316: 1573-7.
21. Fukuda N, Tanaka H, Tominaga Y, Fukagawa M, Kurokawa K, Seino Y. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993, 92: 1436-43.
22. Carling T, Rastad J, Szabo E, Westin G, Akerström G. Reduced parathyroid vitamin D receptor messenger ribonucleic acid levels in primary and secondary hyperparathyroidism. J Clin Endocrinol Metab 2000, 85: 2000-3.
23. Jurutka PW, Remus LS, Whitfield GK, et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol 2000, 14: 401-20.