Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate

Kidney International, Supplement

Volumn 56, Issue 73, 1999, Pages

  Silver, Justin ^a   Yalcindag, Cevdat ^a,b   Sela Brown, Alin ^a   Kilav, Rachel ^a   Naveh Many, Tally ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b ERCIYES UNIVERSITY MEDICAL FACULTY   (Turkey)

Author keywords

Calcium; Parathyroid hormone; Phosphate; Vitamin D

Indexed keywords

CALCITRIOL; CALCIUM; CALRETICULIN; CARRIER PROTEIN; CYTOPLASM PROTEIN; MESSENGER RNA; PARATHYROID HORMONE; PHOSPHATE; CALCIUM BINDING PROTEIN; RIBONUCLEOPROTEIN;

ARTICLE; CALCIUM BLOOD LEVEL; CHRONIC KIDNEY FAILURE; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; HYPOCALCEMIA; HYPOPHOSPHATEMIA; MOLECULAR DYNAMICS; NONHUMAN; PARATHYROID HORMONE RELEASE; PATHOPHYSIOLOGY; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA DEGRADATION; SECONDARY HYPERPARATHYROIDISM; 3' UNTRANSLATED REGION; ANIMAL; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW;

3' UNTRANSLATED REGIONS; ANIMALS; CALCITRIOL; CALCIUM; CALCIUM-BINDING PROTEINS; CALRETICULIN; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HUMANS; PARATHYROID HORMONE; PHOSPHATES; RIBONUCLEOPROTEINS; RNA, MESSENGER;

EID: 0033397335     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.07310.x     Document Type: Article

References (33)

1. RUPP E, MAYER H, WINGENDER E: The promoter of the human parathyroid hormone gene contains a functional cyclic AMP-response element. Nucleic Acid Res 18:5677-5683, 1990
2. 2+ and other ions as extracellular (first) messengers. Physiol Rev 71:371-411, 1991
3. BROWN EM, POLLAK M, SEIDMAN CE, SEIDMAN JG, CHOU YW, RICCARDI D, HEBERT SC: Calcium-ion-sensing cell-surface receptors. N Engl J Med 333:234-240, 1995
4. DEMAY MB, KIERNAN MS, DELUCA HF, KRONENBERG HM: Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 89:8097-8101, 1992
5. FARROW SM, HAWA NS, KARMALI R, HEWISON M, WALTERS JC, O'RIORDAN JL: Binding of the receptor for 1,25-dihydroxyvitamin D3 to the ′-flanking region of the bovine parathyroid hormone gene. J Endocrinol 126:355-359, 1990
6. HAWA NS, O'RIORDAN JL, FARROW SM: Binding of 1,25-dihydroxyvitamin D3 receptors to the 5′-flanking region of the bovine parathyroid hormone gene. J Endocrinol 142:53-60, 1994
7. 3 receptor. Mol Endocrinol 10:206-215, 1996
8. SILVER J, RUSSELL J, SHERWOOD LM: Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci USA 82:4270-4273, 1985
9. RUSSELL J, SILVER J, SHERWOOD LM: The effects of calcium and vitamin D metabolites on cytoplasmic mRNA coding for pre-proparathyroid hormone in isolated parathyroid cells. Trans Assoc Am Phys 97:296-303, 1984
10. CANTLEY LK, RUSSELL J, LETTIERI D, SHERWOOD LM: 1,25-Dihydroxyvitamin D3 suppresses parathyroid hormone secretion from bovine parathyroid cells in tissue culture. Endocrinology 117:2114-2119, 1985
11. SILVER J, NAVEH-MANY T, MAYER H, SCHMELZER HJ, POPOVTZER MM: Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest 78:1296-1301, 1986
12. 3 of transcription of the pre-proparathyroid hormone gene. Endocrinology 119:2864-2866, 1986
13. 3. J Biol Chem 263:2203-2208, 1988
14. NAVEH-MANY T, MARX R, KESHET H, PIKE JW, SILVER J: Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo. J Clin Invest 86:1968-1975, 1990
15. PATEL SR, KE HQ, VANHOLDER R, KOENIG, R, HSU CH: Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxin. J Clin Invest 96:50-59, 1995
16. WHEELER DG, HORSFORD J, MICHALAK M, WHITE JH, HENDY GN: Calreticulin inhibits vitamin D3 signal transduction. Nucleic Acids Res 23:3268-3274, 1995
17. SELA-BROWN A, RUSSELL J, KOSZEWSKI NJ, MICHALAK M, NAVEH-MANY T, SILVER J: Calreticulin inhibits vitamin D's action on the PTH gene in vitro and may prevent vitamin D's effect in vivo in hypocalcemic rats. Mol Endocrinol 12:1193-1200, 1998
18. 2+-sensing receptor from bovine parathyroid. Nature 366:575-580, 1993
19. 2+ -sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 81:1598-1606, 1996
20. NAVEH-MANY T, SILVER J: Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Clin Invest 86:1313-1319, 1990
21. NAVEH-MANY T, FRIEDLAENDER MM, MAYER H, SILVER J: Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of 1,25-dihydroxyvitamin D. Endocrinology 125:275-280, 1989
22. YAMAMOTO M, IGARASHI T, MURAMATSU M, FUKAGAWA M, MOTOKURA T, OGATA E: Hypocalcemia increases and hypercalcemia decreases the steady-state level of parathyroid hormone messenger RNA in the rat. J Clin Invest 83:1053-1056, 1989
23. NAVEH-MANY T, RAUE F, GRAUER A, SILVER J: Regulation of calcitonin gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Bone Miner Res 7:1233-1237, 1992
24. MOALLEM E, SILVER J, KILAV R, NAVEH-MANY T: RNA protein binding and post-transcriptional regulation of PTH gene expression by calcium and phosphate. J Biol Chem 273:5253-5259, 1998
25. TATSUMI S, SEGAWA H, MORITA K, HAGA H, KOUDA T, YAMAMOTO H, INOUE Y, NII T, KATAI K, TAKETANI Y, MIYAMOTO KI, TAKEDA E: Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. Endocrinology 139:1692-1699, 1998
26. MIYAMOTO K, TATSUMI S, MORITA K, TAKEDA E: Does the parathyroid 'see' phosphate? Nephrol Dial Transplant 13:2727-2729, 1998
27. SLATOPOLSKY E, BRICKER NS: The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease. Kidney Int 4:141-145, 1973
28. SILVER J, KRONENBERG HM: Parathyroid hormone - molecular biology and regulation. In: Principles of Bone Biology, edited by BILEZIKIAN JB, RAISZ LG, RODAN GA, San Diego, Academic Press, 1996
29. KILAV R, SILVER J, NAVEH-MANY T: Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest 96:327-333, 1995
30. ALMADEN Y, CANALEJO A, HERNANDEZ A, BALLESTEROS E, GARCIA-NAVARRO S, TORRES A, RODRIGUEZ M: Direct effect of phosphorus on parathyroid hormone secretion from whole rat parathyroid glands in vitro. J Bone Miner Res 11:970-976, 1996
31. SLATOPOLSKY E, FINCH J, DENDA M, RITTER C, ZHONG A, DUSSO A, MACDONALD P, BROWN AJ: Phosphate restriction prevents parathyroid cell growth in uremic rats. High phosphate directly stimulates PTH secretion in vitro. J Clin Invest 97:2534-2540, 1996
32. NIELSEN PK, FELDT-RASMUSEN U, OLGAARD K: A direct effect of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells. Nephrol Dial Transplant 11:1762-1768, 1996
33. YALCINDAG C, SILVER J, NAVEH-MANY T: Mechanism of increased PTH mRNA in experimental uremia: roles of protein RNA binding and RNA degradation. J Am Soc Nephrol (in press)