Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP)·Cdk2·cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17235-17242

  Chinami, Masanobu ^a   Yano, Yosihiko ^b   Yang, Xing ^b   Salahuddin, Saira ^b   Moriyama, Kosei ^d   Shiroishi, Mitsunori ^e   Turner, Helen ^f   Shirakawa, Taro ^g,h   Adra, Chaker N ^b,c,i  

^a KYUSHU WOMEN'S UNIVERSITY   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d Fukuoka Dental Foundation   (Japan)

^e KYUSHU UNIVERSITY   (Japan)

^f QUEEN S MEDICAL CENTER   (United States)

^g KYOTO UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Japan)

^h RIKEN   (Japan)

ⁱ BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; ENZYME KINETICS; MOLECULAR BIOLOGY; PHOSPHORUS;

KAP KINETICS; NUCLEAR MEMBRANE PROTEINS; PHOSPHATASE; PHOSPHORYLATION;

ENZYMES;

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE ASSOCIATED PHOSPHATASE; HTM4 PROTEIN; MEMBRANE PROTEIN; PHOSPHATASE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; CDK2 PROTEIN, HUMAN; CDKN3 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; ION; MS4A3 PROTEIN, HUMAN; PROTEIN TYROSINE PHOSPHATASE; RECOMBINANT PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DEPHOSPHORYLATION; DISSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; BINDING SITE; BIOLOGICAL MODEL; CELL NUCLEUS; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DOSE RESPONSE; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; TIME; WESTERN BLOTTING;

AMINO ACID SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CELL NUCLEUS; CIRCULAR DICHROISM; CLONING, MOLECULAR; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HUMANS; IONS; KINETICS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE; TIME FACTORS; TYROSINE;

EID: 20444469639     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413437200     Document Type: Article

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