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Volumn 17, Issue 2, 1998, Pages 153-169

Trichloroethylene: A current review of metabolism, mode of action, and regulatory considerations

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; GLUTATHIONE; TRICHLOROETHYLENE;

EID: 0031891109     PISSN: 10769188     EISSN: None     Source Type: Journal    
DOI: 10.1080/107691898229387     Document Type: Review
Times cited : (12)

References (68)
  • 1
    • 0024307512 scopus 로고
    • Changes in peroxisomes and mitochondria in liver of ethionine exposed rats: A biochemical and morphological investigation
    • Aersaether, N., Aarsland, A., Kryvi, H., Nilsson, A., Svardal, A., Ueland, P. M., and Berge, R. K. 1989. Changes in peroxisomes and mitochondria in liver of ethionine exposed rats: A biochemical and morphological investigation. Carcinogenesis 10:987-994.
    • (1989) Carcinogenesis , vol.10 , pp. 987-994
    • Aersaether, N.1    Aarsland, A.2    Kryvi, H.3    Nilsson, A.4    Svardal, A.5    Ueland, P.M.6    Berge, R.K.7
  • 2
    • 0003893921 scopus 로고
    • Health Effects Section. U.S. Department of Health and Human Services. Atlanta, GA
    • Agency for Toxic Substances Disease Registry. 1993. Toxicological Profile for Trichloroethylene (Health Effects Section). U.S. Department of Health and Human Services. Atlanta, GA.
    • (1993) Toxicological Profile for Trichloroethylene
  • 3
    • 0028932719 scopus 로고
    • Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: Identity with kidney cysteine conjugate β-lyase
    • Anlberati-Giani, D., Malherbe, P., Köhler, C., Lang, G., Kiefer, V., Lahm, H.-W., and Cesura, A. M. 1995. Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: Identity with kidney cysteine conjugate β-lyase. J. Neurochem. 64:1448-1455.
    • (1995) J. Neurochem. , vol.64 , pp. 1448-1455
    • Anlberati-Giani, D.1    Malherbe, P.2    Köhler, C.3    Lang, G.4    Kiefer, V.5    Lahm, H.-W.6    Cesura, A.M.7
  • 4
    • 84916515725 scopus 로고
    • Notice of intended change - Trichloroethylene
    • American Conference of Governmental Industrial Hygienists
    • American Conference of Governmental Industrial Hygienists. 1992. Notice of intended change - Trichloroethylene. Appl. Occup. Environ. Hyg. 7:786-791.
    • (1992) Appl. Occup. Environ. Hyg. , vol.7 , pp. 786-791
  • 6
    • 0029075402 scopus 로고
    • Cancer incidence among Finnish workers exposed to halogenated hydrocarbons
    • Anttila, A., Pukkala, E., Sallmen, M., Hernberg, S., and Hemminki, K. 1995. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J. Occup. Med. 37:797-806.
    • (1995) J. Occup. Med. , vol.37 , pp. 797-806
    • Anttila, A.1    Pukkala, E.2    Sallmen, M.3    Hernberg, S.4    Hemminki, K.5
  • 7
    • 0028344623 scopus 로고
    • Updated and expanded Swedish cohort study of trichloroethylene and cancer risk
    • Axelson, O., Selden, A., Andersson, K., and Hogstedt, C. 1994. Updated and expanded Swedish cohort study of trichloroethylene and cancer risk. J. Occup. Med. 36:556-562.
    • (1994) J. Occup. Med. , vol.36 , pp. 556-562
    • Axelson, O.1    Selden, A.2    Andersson, K.3    Hogstedt, C.4
  • 8
    • 0028208243 scopus 로고
    • Suppression of liver cell apoptosis in vitro by the nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin
    • Bayly, A. C., Roberts, R. A., and Dive, C. 1994. Suppression of liver cell apoptosis in vitro by the nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J. Cell Biol. 125:197-203.
    • (1994) J. Cell Biol. , vol.125 , pp. 197-203
    • Bayly, A.C.1    Roberts, R.A.2    Dive, C.3
  • 9
    • 0029912279 scopus 로고    scopus 로고
    • Biotransformation of trichloroethene: Dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation
    • Bernauer, U., Birner, G., Dekant, W., and Henschler, D. 1996. Biotransformation of trichloroethene: Dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation. Arch. Toxicol. 70:338-346.
    • (1996) Arch. Toxicol. , vol.70 , pp. 338-346
    • Bernauer, U.1    Birner, G.2    Dekant, W.3    Henschler, D.4
  • 10
    • 0027267051 scopus 로고
    • Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: Implications for the risk of trichloroethene exposure
    • Birner, G., Vamvakas, S., Dekant, W., and Henschler, D. 1993. Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: Implications for the risk of trichloroethene exposure. Environ. Health Perspect. 99:281-284.
    • (1993) Environ. Health Perspect. , vol.99 , pp. 281-284
    • Birner, G.1    Vamvakas, S.2    Dekant, W.3    Henschler, D.4
  • 12
    • 0024390938 scopus 로고
    • Metabolism, toxicity, and carcinogenicity of trichloroethylene
    • Bruckner, J. V., Davis, B. D., and Blancato, J. N. 1989. Metabolism, toxicity, and carcinogenicity of trichloroethylene. CRC Crit. Rev. Toxicol. 20:31-50.
    • (1989) CRC Crit. Rev. Toxicol. , vol.20 , pp. 31-50
    • Bruckner, J.V.1    Davis, B.D.2    Blancato, J.N.3
  • 13
    • 0027253691 scopus 로고
    • The role of dichloro acetate in hepatocarcinogenicity of trichloroethylene
    • Bull, R. J., Templin, M., Larson, J. L., and Stevens, D. K. 1993. The role of dichloro acetate in hepatocarcinogenicity of trichloroethylene. Toxicol. Lett. 68:203-211.
    • (1993) Toxicol. Lett. , vol.68 , pp. 203-211
    • Bull, R.J.1    Templin, M.2    Larson, J.L.3    Stevens, D.K.4
  • 14
    • 0028567070 scopus 로고
    • The role of the cellular antioxidant defense in oxidant carcinogenesis
    • Cerutti, P., Ghosh, R., Oya, Y., and Armstad, P. 1994. The role of the cellular antioxidant defense in oxidant carcinogenesis. Environ. Health Perspect. 102:123-130.
    • (1994) Environ. Health Perspect. , vol.102 , pp. 123-130
    • Cerutti, P.1    Ghosh, R.2    Oya, Y.3    Armstad, P.4
  • 15
    • 0028710166 scopus 로고
    • Effects of di-(2-ethylhexyl)phthalate on peroxisomes of liver, kidney and brain of lactating rats and their pups
    • Cimini, A. M., Sulli, A., Stefanini, S., Serafini, B., Moreno, S., Rossi, L., Giorgi, M., and Ceru, M. P. 1994. Effects of di-(2-ethylhexyl)phthalate on peroxisomes of liver, kidney and brain of lactating rats and their pups. Cell. Mol. Biol. 40:1063-1076.
    • (1994) Cell. Mol. Biol. , vol.40 , pp. 1063-1076
    • Cimini, A.M.1    Sulli, A.2    Stefanini, S.3    Serafini, B.4    Moreno, S.5    Rossi, L.6    Giorgi, M.7    Ceru, M.P.8
  • 19
    • 0029150885 scopus 로고
    • Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene
    • Clewell, H. J., Gentry, P. R., Gearhart, J. M., Allen, B. C., and Andersen, M. E. 1995b. Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene. Chemosphere 31:2561-2578.
    • (1995) Chemosphere , vol.31 , pp. 2561-2578
    • Clewell, H.J.1    Gentry, P.R.2    Gearhart, J.M.3    Allen, B.C.4    Andersen, M.E.5
  • 20
    • 13144299916 scopus 로고
    • Identification of N-acetyl(2,2-dichlorovinyl)- And N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in rats
    • Commandeur, J. N. M., and Vermeulen, N. P. E. 1990. Identification of N-acetyl(2,2-dichlorovinyl)-and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in rats. Toxicol. Appl. Pharmacol. 110:303-314.
    • (1990) Toxicol. Appl. Pharmacol. , vol.110 , pp. 303-314
    • Commandeur, J.N.M.1    Vermeulen, N.P.E.2
  • 21
    • 0022503191 scopus 로고
    • Identification of S-(1,2-dichlorovinyl)-N-acetyl-cysteme as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats
    • Dekant, W., Metzler, M., and Henschler, D. 1986a. Identification of S-(1,2-dichlorovinyl)-N-acetyl-cysteme as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats. Biochem. Pharmacol. 35:2455-2458.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 2455-2458
    • Dekant, W.1    Metzler, M.2    Henschler, D.3
  • 22
    • 0022622806 scopus 로고
    • Absorption, elimination and metabolism of trichloroethylene: A quantitative comparison between rats and mice
    • Dekant, W., Schultz, A., Metzler, M., and Henschler, D. 1986b. Absorption, elimination and metabolism of trichloroethylene: A quantitative comparison between rats and mice. Xenobiotica 16:143-152.
    • (1986) Xenobiotica , vol.16 , pp. 143-152
    • Dekant, W.1    Schultz, A.2    Metzler, M.3    Henschler, D.4
  • 23
    • 0020078719 scopus 로고
    • Assay of cysteine conjugate β-lyase activity with S-(2-benzothiazolyl) cysteine as substrate
    • Dohn, D. R., and Anders, M. W. 1982. Assay of cysteine conjugate β-lyase activity with S-(2-benzothiazolyl) cysteine as substrate. Anal. Biochem. 120:379-386.
    • (1982) Anal. Biochem. , vol.120 , pp. 379-386
    • Dohn, D.R.1    Anders, M.W.2
  • 24
    • 0022335175 scopus 로고
    • Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment
    • Elcombe, C. R. 1985. Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment. Arch. Toxicol. 8(suppl.):6-17.
    • (1985) Arch. Toxicol. , vol.8 , Issue.SUPPL. , pp. 6-17
    • Elcombe, C.R.1
  • 25
    • 0028853943 scopus 로고
    • Trichloroethylene - A review of the literature from a health effects perspective
    • Gist, G. L., and Burg, J. R. 1995. Trichloroethylene - A review of the literature from a health effects perspective. Toxicol. Ind. Health 11:253-307.
    • (1995) Toxicol. Ind. Health , vol.11 , pp. 253-307
    • Gist, G.L.1    Burg, J.R.2
  • 26
    • 0021824749 scopus 로고
    • Species differences in response to trichloroethylene. II. Biotransformation in rats and mice
    • Green, T., and Prout, M. S. 1985. Species differences in response to trichloroethylene. II. Biotransformation in rats and mice. Toxicol. Appl. Pharmacol. 79:401-411.
    • (1985) Toxicol. Appl. Pharmacol. , vol.79 , pp. 401-411
    • Green, T.1    Prout, M.S.2
  • 27
    • 0018525032 scopus 로고
    • Some halogenated hydrocarbons
    • Lyons: World Health Organization
    • International Agency for Research on Cancer. 1979. Some halogenated hydrocarbons. Monogr. Eval. Carcinogen. Risk Chem. Hum., 20, Lyons: World Health Organization.
    • (1979) Monogr. Eval. Carcinogen. Risk Chem. Hum. , vol.20
  • 28
    • 0029429522 scopus 로고
    • Dry cleaning, some chlorinated solvents and other industrial chemicals
    • International Agency for Research on Cancer. 1995. Dry cleaning, some chlorinated solvents and other industrial chemicals. IARC Monogr. Eval. Carcinogen. Risks Hum. 63.
    • (1995) IARC Monogr. Eval. Carcinogen. Risks Hum. , vol.63
  • 29
    • 0022625032 scopus 로고
    • Cysteine conjugate β-lyase in the gastrointestinal bacterium Eubacterium limosum
    • Larsen, G. L., and Stevens, J. L. 1986. Cysteine conjugate β-lyase in the gastrointestinal bacterium Eubacterium limosum. Mol. Pharmacol. 29:97-103.
    • (1986) Mol. Pharmacol. , vol.29 , pp. 97-103
    • Larsen, G.L.1    Stevens, J.L.2
  • 30
    • 0026633654 scopus 로고
    • Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate
    • Larson, J. L., and Bull, R. J. 1992a. Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate. Toxicol. Appl. Pharmacol. 115:278-285.
    • (1992) Toxicol. Appl. Pharmacol. , vol.115 , pp. 278-285
    • Larson, J.L.1    Bull, R.J.2
  • 31
    • 0026684304 scopus 로고
    • Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice
    • Larson, J. L., and Bull, R. J. 1992b. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol. 115:268-277.
    • (1992) Toxicol. Appl. Pharmacol. , vol.115 , pp. 268-277
    • Larson, J.L.1    Bull, R.J.2
  • 32
    • 0023003510 scopus 로고
    • Renal cysteine conjugate β-lyase: Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane
    • Lash, L. H., Elfarra, A. A., and Anders, M. W. 1986. Renal cysteine conjugate β-lyase: Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. J. Biol. Chem. 261:5930-5935.
    • (1986) J. Biol. Chem. , vol.261 , pp. 5930-5935
    • Lash, L.H.1    Elfarra, A.A.2    Anders, M.W.3
  • 33
    • 0002080104 scopus 로고
    • Glutathione homeostasis and glutathione S-conjugate toxicity in kidney
    • Lash, L. H., Jones, D. P., and Anders, M. W. 1988. Glutathione homeostasis and glutathione S-conjugate toxicity in kidney. Rev. Biochem. Toxicol. 9:29-67.
    • (1988) Rev. Biochem. Toxicol. , vol.9 , pp. 29-67
    • Lash, L.H.1    Jones, D.P.2    Anders, M.W.3
  • 34
    • 0025228615 scopus 로고
    • Purification and characterization of human kidney cysteine conjugate β-lyase activity
    • Lash, L. H., Nelson, R. M., Van Dyke, R. A., and Anders, M. W. 1990. Purification and characterization of human kidney cysteine conjugate β-lyase activity. Drug Metab. Dispos. 18:50-54.
    • (1990) Drug Metab. Dispos. , vol.18 , pp. 50-54
    • Lash, L.H.1    Nelson, R.M.2    Van Dyke, R.A.3    Anders, M.W.4
  • 35
    • 0029166099 scopus 로고
    • Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity
    • Lash, L. H., Xu, Y., Elfarra, A. A., Duescher, R. J., and Parker, J. C. 1995. Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity. Drug. Metab. Dispos. 23:846-853.
    • (1995) Drug. Metab. Dispos. , vol.23 , pp. 846-853
    • Lash, L.H.1    Xu, Y.2    Elfarra, A.A.3    Duescher, R.J.4    Parker, J.C.5
  • 36
    • 0013494744 scopus 로고
    • Male rat-specific light hydrocarbon nephropathy
    • eds. J. B. Hook and R. S. Goldstein, New York: Raven Press
    • Lehman-McKeeman, L. D. 1993. Male rat-specific light hydrocarbon nephropathy. In Toxicology of the kidney, 2nd ed., eds. J. B. Hook and R. S. Goldstein, pp. 477-494. New York: Raven Press.
    • (1993) Toxicology of the Kidney, 2nd Ed. , pp. 477-494
    • Lehman-McKeeman, L.D.1
  • 37
    • 0025232323 scopus 로고
    • Lysosomal degradation of α2u-globulin and α2u-globulin-xenobiotic conjugates
    • Lehman-McKeeman, L. D., Rivera-Torres, M. I., and Caudill, D. 1990. Lysosomal degradation of α2u-globulin and α2u-globulin-xenobiotic conjugates. Toxicol. Appl. Pharmacol. 103:539-548.
    • (1990) Toxicol. Appl. Pharmacol. , vol.103 , pp. 539-548
    • Lehman-McKeeman, L.D.1    Rivera-Torres, M.I.2    Caudill, D.3
  • 38
    • 0029001375 scopus 로고
    • Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain
    • Malherbe, P., Alberati-Giani, D., Köhler, C., and Cesura, A. M. 1995. Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain. FEBS Lett. 367:141-144.
    • (1995) FEBS Lett. , vol.367 , pp. 141-144
    • Malherbe, P.1    Alberati-Giani, D.2    Köhler, C.3    Cesura, A.M.4
  • 40
    • 0026706646 scopus 로고
    • An alternative hypothesis on the role of chemically induced protein droplet (α2u-globin) nephropathy in renal carcinogenesis
    • Melnick, R. 1992. An alternative hypothesis on the role of chemically induced protein droplet (α2u-globin) nephropathy in renal carcinogenesis. Regul. Toxicol. Pharmacol. 16:111-125.
    • (1992) Regul. Toxicol. Pharmacol. , vol.16 , pp. 111-125
    • Melnick, R.1
  • 41
    • 0020473257 scopus 로고
    • Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide
    • Miller, R. E., and Guengerich, F. P. 1982. Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide. Biochemistry 21:1090-1097.
    • (1982) Biochemistry , vol.21 , pp. 1090-1097
    • Miller, R.E.1    Guengerich, F.P.2
  • 42
    • 0020683796 scopus 로고
    • Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted systems containing cytochrome P-450
    • Miller, R. E., and Guengerich, F. P. 1983. Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted systems containing cytochrome P-450. Cancer Res. 43:1145-1152.
    • (1983) Cancer Res. , vol.43 , pp. 1145-1152
    • Miller, R.E.1    Guengerich, F.P.2
  • 43
    • 0003817412 scopus 로고
    • Chapter 6. Washington, DC: National Academy Press
    • National Research Council. 1995. Biologic markers in urinary toxicology, Chapter 6. Washington, DC: National Academy Press.
    • (1995) Biologic Markers in Urinary Toxicology
  • 44
    • 0023755328 scopus 로고
    • Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat
    • Nemali, M. R., Usuda, N., Reddy, M. K., Oyasu, K., Hashimoto, T., Osumi, T., Rao, M. S., and Reddy, J. K. 1988. Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat. Cancer Res. 48:5316-5324.
    • (1988) Cancer Res. , vol.48 , pp. 5316-5324
    • Nemali, M.R.1    Usuda, N.2    Reddy, M.K.3    Oyasu, K.4    Hashimoto, T.5    Osumi, T.6    Rao, M.S.7    Reddy, J.K.8
  • 45
    • 0023819178 scopus 로고
    • The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat
    • Odum, J., Green, T., Foster, J. R., and Hext, P. M. 1988. The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol. Appl. Pharmacol. 92:103-112.
    • (1988) Toxicol. Appl. Pharmacol. , vol.92 , pp. 103-112
    • Odum, J.1    Green, T.2    Foster, J.R.3    Hext, P.M.4
  • 46
    • 0026785626 scopus 로고
    • A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene
    • Odum, J., Foster, J. R., and Green, T. 1992. A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene. Chem. Biol. Interact. 83:135-153.
    • (1992) Chem. Biol. Interact. , vol.83 , pp. 135-153
    • Odum, J.1    Foster, J.R.2    Green, T.3
  • 47
    • 0025968912 scopus 로고
    • Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney
    • Ponchaut, S., Draye, J. P., Veitch, K., and van Hoof, F. 1991. Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Biochem. Pharmacol. 41:1419-1428.
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 1419-1428
    • Ponchaut, S.1    Draye, J.P.2    Veitch, K.3    Van Hoof, F.4
  • 48
    • 0026004460 scopus 로고
    • An overview of peroxisome proliferator-induced hepatocarcinogenesis
    • Rao, M. S., and Reddy, J. K. 1991. An overview of peroxisome proliferator-induced hepatocarcinogenesis. Environ. Health Perspect. 93:205-209.
    • (1991) Environ. Health Perspect. , vol.93 , pp. 205-209
    • Rao, M.S.1    Reddy, J.K.2
  • 50
    • 0025900416 scopus 로고
    • The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice
    • Richmond, R. E., DeAngelo, A. B., Potter, C. L., and Daniel, F. B. 1991. The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice. Carcinogenesis 12:1383-1387.
    • (1991) Carcinogenesis , vol.12 , pp. 1383-1387
    • Richmond, R.E.1    DeAngelo, A.B.2    Potter, C.L.3    Daniel, F.B.4
  • 51
    • 0029026852 scopus 로고
    • Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F433) rats
    • Richmond, R. E., Carter, J. H., Carter, H. W., Daniel, F. B., and DeAngelo, A. B. 1995. Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F433) rats. Cancer Lett. 92:67-76.
    • (1995) Cancer Lett. , vol.92 , pp. 67-76
    • Richmond, R.E.1    Carter, J.H.2    Carter, H.W.3    Daniel, F.B.4    DeAngelo, A.B.5
  • 52
    • 0022463003 scopus 로고
    • Induction of neoplastic lesions in the livers of C57B1 X C3HF1 mice by chloral hydrate
    • Rijhsinghani, K. S., Abrahams, C., Swerdlow, M. A., Rao, K. V., and Ghose, T. 1986. Induction of neoplastic lesions in the livers of C57B1 X C3HF1 mice by chloral hydrate. Cancer Detect. Prev. 9:279-288.
    • (1986) Cancer Detect. Prev. , vol.9 , pp. 279-288
    • Rijhsinghani, K.S.1    Abrahams, C.2    Swerdlow, M.A.3    Rao, K.V.4    Ghose, T.5
  • 54
    • 0029150242 scopus 로고
    • In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes
    • Snyder, R. D., Pullman, J., Carter, J. H., Carter, H. W., and DeAngelo, A. B. 1995. In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes. Cancer Res. 55:3702-3705.
    • (1995) Cancer Res. , vol.55 , pp. 3702-3705
    • Snyder, R.D.1    Pullman, J.2    Carter, J.H.3    Carter, H.W.4    Deangelo, A.B.5
  • 55
    • 0025784352 scopus 로고
    • Retrospective cohort mortality study of workers at an aircraft maintenance facility. II. Exposures and the assessment
    • Spirtas, R., Stewart, P., and Lee, S. 1991. Retrospective cohort mortality study of workers at an aircraft maintenance facility. II. Exposures and the assessment. Br. J. Ind. Med. 48:531-537.
    • (1991) Br. J. Ind. Med. , vol.48 , pp. 531-537
    • Spirtas, R.1    Stewart, P.2    Lee, S.3
  • 56
    • 0027359494 scopus 로고
    • Have animal data been used inappropriately to estimate risks to humans from environmental trichloroethylene?
    • Steinberg, A. D., and DeSesso, J. M. 1993. Have animal data been used inappropriately to estimate risks to humans from environmental trichloroethylene? Regul. Toxicol. Pharmacol. 18:137-153.
    • (1993) Regul. Toxicol. Pharmacol. , vol.18 , pp. 137-153
    • Steinberg, A.D.1    Desesso, J.M.2
  • 57
    • 0022263521 scopus 로고
    • Cysteine conjugate β-lyase in rat kidney cortex: Subcellular localization and relationship to the hepatic enzymes
    • Stevens, J. L. 1985a. Cysteine conjugate β-lyase in rat kidney cortex: Subcellular localization and relationship to the hepatic enzymes. Biochem. Biophys. Res. Commun. 129:499-504.
    • (1985) Biochem. Biophys. Res. Commun. , vol.129 , pp. 499-504
    • Stevens, J.L.1
  • 58
    • 0022363122 scopus 로고
    • Isolation and characterization of a rat liver enzyme with both cysteine conjugate β-lyase activity and kynureninase activity
    • Stevens, J. L. 1985b. Isolation and characterization of a rat liver enzyme with both cysteine conjugate β-lyase activity and kynureninase activity. J. Biol. Chem. 260:7945-7950.
    • (1985) J. Biol. Chem. , vol.260 , pp. 7945-7950
    • Stevens, J.L.1
  • 59
    • 0020530057 scopus 로고
    • Cysteine conjugate β-layse
    • Stevens, J. L., and Jakoby, W. B. 1983. Cysteine conjugate β-layse. Mol. Pharmacol. 23:761-765.
    • (1983) Mol. Pharmacol. , vol.23 , pp. 761-765
    • Stevens, J.L.1    Jakoby, W.B.2
  • 60
    • 0025882831 scopus 로고
    • Trichloroacetic acid: Studies on uptake and effects on hepatic DNA and liver growth in mouse
    • Styles, J. A., Wyatt, I., and Coutts, C. 1991. Trichloroacetic acid: Studies on uptake and effects on hepatic DNA and liver growth in mouse. Carcinogenesis 12:1715-1719.
    • (1991) Carcinogenesis , vol.12 , pp. 1715-1719
    • Styles, J.A.1    Wyatt, I.2    Coutts, C.3
  • 61
    • 0026671184 scopus 로고
    • Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone
    • Sundseth, S. S., and Waxman, D. J. 1992. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J. Biol. Chem. 267:3915-3921.
    • (1992) J. Biol. Chem. , vol.267 , pp. 3915-3921
    • Sundseth, S.S.1    Waxman, D.J.2
  • 62
    • 0027848920 scopus 로고
    • 2u-Globulin nephropathy: Review of the cellular and molecular mechanisms involved and their implications for human risk assessment
    • 2u-Globulin nephropathy: Review of the cellular and molecular mechanisms involved and their implications for human risk assessment. Environ. Health Perspect. Suppl. 6:39-44.
    • (1993) Environ. Health Perspect. Suppl. , vol.6 , pp. 39-44
    • Swenberg, J.A.1
  • 64
    • 0021341549 scopus 로고
    • Purification and characterization of C-S lyase from Fusobacterium varium: A C-S cleavage enzyme of cysteine conjugates and some S-containing amino acids
    • Tomisawa, H., Suzuki, S., Ichihara, S., Fukazawa, H., and Tateishi, M. 1984. Purification and characterization of C-S lyase from Fusobacterium varium: A C-S cleavage enzyme of cysteine conjugates and some S-containing amino acids. J. Biol. Chem. 259:2588-2593.
    • (1984) J. Biol. Chem. , vol.259 , pp. 2588-2593
    • Tomisawa, H.1    Suzuki, S.2    Ichihara, S.3    Fukazawa, H.4    Tateishi, M.5
  • 67
    • 0000060569 scopus 로고    scopus 로고
    • Proposed guidelines for carcinogen risk assessment: Notice
    • U.S. Environmental Protection Agency. 1996. Proposed guidelines for carcinogen risk assessment: notice. Fed. Reg. 61:17960-18011.
    • (1996) Fed. Reg. , vol.61 , pp. 17960-18011
  • 68
    • 13144270972 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency. 1997. Glossary of risk assessmentrelated terms. From the U.S. EPA Internet Homepage, http://www.epa.gov/ngispgm3/iris/glossary.html/.
    • (1997) Glossary of Risk Assessmentrelated Terms


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