Spirochetes at the forefront of periodontal infections

Periodontology 2000

Volumn 38, Issue , 2005, Pages 13-32

  Ellen, Richard P ^a   Galimanas, Vaia B ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BACTERIAL INFECTION; BACTERIUM IDENTIFICATION; CLASSIFICATION; DISEASE MODEL; ECOSYSTEM; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOGENICITY; PERIODONTAL DISEASE; REVIEW; TREPONEMA; TREPONEMA DENTICOLA; VIRULENCE;

ANIMALS; BACTERIAL TYPING TECHNIQUES; DISEASE MODELS, ANIMAL; ECOSYSTEM; HUMANS; PERIODONTAL DISEASES; TREPONEMA; TREPONEMA DENTICOLA; TREPONEMAL INFECTIONS; VIRULENCE;

EID: 20444440319     PISSN: 09066713     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0757.2005.00108.x     Document Type: Review

References (183)

1. Aimetti M, Romano F, Torta I, Cirillo D, Caposio P, Romangnoli R. Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis: results after 12 months. J Clin Periodontol 2004: 31: 166-172.
2. Amin M, Ho ACS, Lin J, Paes Batista da Silva A, Glogauer M, Ellen RP. Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein (Msp). Infect Immun 2004: 72: 3650-3654.
3. Apatzidou DA, Riggio MP, Kinane DF. Quadrant root planning versus same-day full-mouth root planning. II. Microbiological findings. J Clin Periodontol 2004: 31: 141-148.
4. Armitage GC, Dickinson WR, Jenderseck RS, Levine SM, Chambers DW. Relationship between the percentage of subgingival spirochetes and the severity of periodontal disease. J Periodontol 1982: 53: 550-556.
5. Asai Y, Jinno T, Ogawa T. Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through toll-like receptor 2. Infect Immun 2003: 71: 717-725.
6. Baehni PC, Song M, McCulloch CAG, Ellen RP. Treponema denticola induces actin rearrangement and detachment of human gingival fibroblasts. Infect Immun 1992: 60: 3360-3368.
7. Barron SL, Riviere GR, Simonson LG, Lukehart SA, Tira DE, O'Neil D. Use of monoclonal antibodies to enumerate spirochetes and identify Treponema denticola in dental plaque of children, adolescents, and young adults. Oral Microbiol Immunol 1991: 6: 97-101.
8. Beikler T, Abdeen G, Schnitzer S, Salzer S, Ehmke B, Heinecke A, Flemmig TF. Microbiological shifts in intra-and extraoral habitats following mechanical periodontal therapy. J Clin Periodontol 2001: 31: 777-783.
9. Brissette CA, Lukehart SA. Treponema denticola is resistant to human β-defensins. Infect Immun 2002: 70: 3982-3984.
10. Carlsson J. Growth and nutrition as ecological factors. In: Kuramitsu HK, Ellen RP, eds. Oral Bacterial Ecology, The Molecular Basis. Wymondham, Norfolk: Horizon Scientific Press, 2000: 67-130.
11. Chan ECS, De Ciccio A, McLaughlin R, Klitorinos A, Siboo R. An inexpensive solid medium for obtaining colonyforming units or oral spirochetes. Oral Microbiol Immunol 1997: 12: 372-376.
12. Chan ECS, Siboo R, Keng T, Psarra N, Hurley R, Cheng S-L, Iugovaz I. Treponema denticola (ex Brumpt 1925) sp. nov., nom., rev. and identification of new sprirochete isolates from periodontal pockets. Int J Syst Bacteriol 1993: 43: 196-203.
13. Chan ECS, Siboo R, Touyz LZ, Qui YS, Klitorinos A. A successful method for quantifying viable oral anaerobic spirochetes. Oral Microbiol Immunol 1993: 8: 80-83.
14. Cheng S-L, Chan ECS. The routine isolation, growth, and maintenance of the intermediate-size anaerobic oral spirochetes from periodontal pockets. J Periodontal Res 1983: 18: 362-368.
15. Chi B, Qi M, Kuramitsu HK. Role of dentilisin in Treponema denticola epithelial cell layer penetration. Res Microbiol 2003: 154: 637-643.
16. Choi B-K, Lee HJ, Kang JH, Jeong GJ, Min CK, Yoo Y-J. Induction of osteoclastogensis and matrix metalloproteinase expression by the lipooligosaccharide of Treponema denticola. Infect Immun 2003: 71: 226-233.
17. Choi B-K, Nattermann H, Grund S, Haider W, Göbel UB. Spirochetes from digital dermatitis lesions in cattle are closely related to treponemes associated with human periodontitis. Int J Syst Bacteriol 1997: 47: 175-181.
18. Choi B-K, Paster BJ, Dewhirst FE, Göbel UB. Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive periodontitis. Infect Immun 1994: 62: 1889-1895.
19. Choi B-K, Wyss C, Göbel UB. Phylogenetic analysis of pathogen related oral spirochetes. J Clin Microbiol 1996: 34: 1922-1925.
20. Chu L, Dong Z, Xu X, Cochran DL, Ebersole JL. Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression. Infect Immun 2002: 70: 1113-1120.
21. Chu L, Ebersole JL, Kurzban GP, Holt SC. Cystalysin, a 46-kilodalton cysteine desulfhydrase from Treponema denticola, with hemolytic and hemoxidative activities. Infect Immun 1997: 65: 3231-3238.
22. Chu L, Ebersole JL, Kurzban GP, Holt SC. Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization. Clin Infect Dis 1999: 28: 442-450.
23. Correia FF, Plummer AR, Ellen RP, Wyss C, Boches SK, Galvin JL, Paster BJ, Dewhirst FE. Two paralogous families of a two-gene subtilisin operon are widely distributed in oral treponemes. J Bacteriol 2003: 185: 6860-6869.
24. Dawson JR, Ellen RP. Tip-oriented adherence of Treponema denticola to fibronectin. Infect Immun 1990: 58: 3924-3928.
25. Dawson JR, Ellen RP. Clustering of fibronectin adhesins toward Treponema denticola tips upon contact with immobilized fibronectin. Infect Immun 1994: 62: 2214-2221.
26. De Boever EH, De Uzeda M, Loesche WJ. Relationship between volatile sulfur compounds, BANA-hydrolyzing bacteria and gingival health in patients with and without complaints of oral malodor. J Clin Dent 1994: 4: 114-119.
27. DeFilippo AB, Ellen RP, McCulloch CAG. Induction of cytoskeletal rearrangements and loss of volume regulation in epithelial cells by Treponema denticola. Arch Oral Biol 1995: 40: 199-207.
28. Deng Q-D, Han Y, Xia X, Kuramitsu HK. Effects of the oral spirochete Treponema denticola on interleukin-8 expression from epithelial cells. Oral Microbiol Immunol 2001: 16: 185-187.
29. Dewhirst FE, Tamer MA, Ericson RE, Lau CN, Levanos VA, Boches SK, Galvin JL, Paster BJ. The diversity of periodontal spirochetes by 16S rRNA analysis. Oral Microbiol Immunol 2000: 15: 196-202.
30. Ding Y, Uitto V-J, Haapasalo M, Lounatmaa K, Konttinen YT, Salo T, Grenier D, Sorsa T. Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes. J Dent Res 1996: 75: 1986-1993.
31. Egli C, Leung WK, Müller KH, Hancock REW, McBride BC. Pore-forming properties of the major 53 kilodalton surface antigen from the outer sheath of Treponema denticola. Infect Immun 1993: 61: 1694-1699.
32. Ehmke B, Bikler T, Riep B, Flemmig T, Göbel U, Moter A. Intraoral dissemination of treponemes after periodontal therapy. Clin Oral Investig 2004: 8: 219-225.
33. Ellen RP. Perturbation and exploitation of host cell cytoskeleton by periodontal pathogens. Microbes Infect 1999: 1: 621-632.
34. Ellen RP. Adhesion of oral spirochetes to host cells and its cytopathogenic consequences. In: Wilson M, editors. Bacteriol Adhesion to Host Tissues. Cambridge: Cambridge University Press, 2002.
35. Ellen RP. Virulence determinants of oral treponemes. In: Lukehart SA, Radolf, J, editors. Molecular Biology and Pathogenesis of Treponemal Infections. Wymondham, Norfolk: Horizon Scientific Press/Caister Academic Press, 2005: in press.
36. Ellen RP, Ko KS-C, Lo C-M, Grove DA, Ishihara K. Insertional inactivation of the prtP gene of Treponema denticola confirms dentilisin's disruption of epithelial junctions. J Mol Microbiol Biotechnol 2000: 2: 581-586.
37. Fiehn N-E, Westergaard J. Cultivation on solid media of spirochetes in subgingival plaque from advanced marginal periodontitis in humans. Scand J Dent Res 1984: 92: 426-435.
38. Fenno JC, Hannam PM, Leung WK, Tamura M, Uitto V-J, McBride BC. Cytopathic effects of the major surface protein and the chymotrypsinlike protease of Treponema denticola. Infect Immun 1998: 66: 1869-1877.
39. Fenno JC, Lee SY, Bayer CH, Ning Y. The opdB locus encodes the trypsin-like peptidase activity of Treponema denticola. Infect Immun 2001: 69: 6193-6200.
40. Fenno JC, McBride BC. Virulence factors of oral treponemes. Anaerobe 1998: 4: 1-17.
41. Fenno JC, Müller K-H, McBride BC. Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola. J Bacteriol 1996: 178: 2489-2497.
42. Fenno JC, Wong GWK, Hannam PM, Müller K-H, Leung WK, McBride BC. Conservation of msp, the gene encoding the major outer sheath membrane protein of oral Treponema spp. J Bacteriol 1997: 179: 1082-1089.
43. Friedman MT, Barber PM, Mordon NJ, Newman HN. The 'plaque-free zone' in health and disease: a scanning electron microscope study. J Periodontol 1992: 63: 890-896.
44. Fukumoto Y, Kato T, Ishihara K, Seida K, Takazoe I, Okuda K. A common antigen of Treponema denticola and other Treponema species detected by monoclonal antibodies. Oral Microbiol Immunol 1989: 4: 112-116.
45. Gopalsami C, Yotis W, Corrigan K, Schade S, Keene J. Effect of outer membrane of Treponema denticola on bone resorption. Oral Microbiol Immunol 1993: 8: 121-124.
46. Grenier D. Characteristics of hemolytic and hemagglutinating activities of Treponema denticola. Oral Microbiol Immunol 1991: 6: 246-249.
47. Grenier D. Demonstration of bimodal coaggregation between Porphyromonas gingivalis and Treponema denticola. Oral Microbiol Immunol 1992: 7: 280-284.
48. Grenier D, Mayrand D. Periodontitis as an ecological imbalance. In: Kuramitsu HK, Ellen RP, editors. Oral Bacterial Ecology, The Molecular Basis. Wymondham, Norfolk: Horizon Scientific Press, 2000.
49. Grenier D, Uitto V-J, McBride BC. Cellular location of a Treponema denticola chymotrypsinlike protease and importance of the protease in migration through the basement membrane. Infect Immun 1990: 58: 347-351.
50. Grys EL, Schade SZ, Cohen ME, Geivelis M, Robinson PJ, Simonson LG. Measurement of proteases in human subgingival dental plaque by fluorescence polarization. Arch Oral Biol 2000: 45: 1101-1106.
51. Haapasalo M, Singh U, McBride BC, Uitto V-J. Sulfhydryl-dependent attachment of Treponema denticola to laminin and other proteins. Infect Immun 1991: 59: 4230-4237.
52. Hashimoto M, Ogawa S, Yasusuki A, Takai Y, Ogawa T. Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin. FEMS Micriobiol Lett, 2003: 226: 267-271.
53. Heuner K, Bergmann I, Heckenback K, Göbel UB. Proteolytic activity among oral Treponema species and cloning of a prtP-like gene of Treponema socranskii subsp. socranskii. FEMS Microbiol Lett 2001: 201: 169-176.
54. Heuner K, Choi B-K, Schade R, Moter A, Otto A, Göbel UB. Cloning and characterization of a gene (mspA) encoding the major sheath protein of Treponema maltophilum ATCC 51939 T. J Bacteriol 1999: 181: 1025-1029.
55. Ishihara K, Kuramitsu HK, Miura T, Okuda K. Dentilisin activity affects the organization of the outer sheath of Treponema denticola. J Bacteriol 1998: 180: 3837-3844.
56. Ishihara K, Miura T, Kuramitsu HK, Okuda K. Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin). Infect Immun 1996: 64: 5178-5186.
57. Kamma JJ, Baehni PC. Five-year maintenance follow-up of early-onset periodontitis patients. J Clin Periodontol 2003: 30: 562-572.
58. Kesavalu L, Falk CW, Davis KJ, Steffen MJ, Xu S, Holt SC, Ebersole JL. Biological characterization of lipopolysaccharide from Treponema pectinovorum. Infect Immun 2002: 70: 211-217.
59. Kesavalu L, Holt SC, Ebersole JL. Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine model. Oral Microbiol Immunol 1998: 13: 373-377.
60. Kesavalu L, Holt SC, Ebersole JL. Environmental modulation of oral treponeme virulence in a murine model. Infect Immun 1999: 67: 2783-2789.
61. Kesavalu L, Holt SC, Ebersole JL. Lack of humoral immune protection against Treponema denticola virulence in a murine model. Infect Immun 1999: 67: 5736-5746.
62. Kesavalu L, Walker SG, Holt SC, Crowley RR, Ebersole JL. Virulence characteristics of oral treponemes in a murine model. Infect Immun 1997: 65: 5096-5102.
63. Keyes PH, Rams TE. A rationale for management of periodontal diseases: rapid identification of microbial 'therapeutic targets' with phase-contrast microscopy. J Am Dent Assoc 1983: 106: 803-812.
64. Kigure T, Saito A, Seida K, Yamada S, Ishihara K, Okuda K. Distribution of Porphyromonas gingivalis and Treponema denticola in human subgingival plaque at different periodontal pocket depths examined by immunohistochemical methods. J Periodontal Res 1995: 30: 332-341.
65. Ko KS-C, Glogauer M, McCulloch CAG, Ellen RP. Treponema denticola outer membrane inhibits calcium flux in gingival fibroblasts. Infect Immun 1998: 66: 703-709.
66. Ko KS-C, Lo C-M, Ferrier J, Hannam P, Tamura M, McBride BC, Ellen RP. Cell-substrate impedance analysis of epithelial cell shape and micromotion upon challenge with bacterial proteins that perturb extracellular matrix and cytoskeleton. J Microbiol Methods 1998: 34: 125-132.
67. Koseki T, Benno Y, Zhang-Koseki YJ, Umeda M, Ishikawa I. Detection frequencies and the colony-forming unit recovery of oral treponemes by different cultivation methods. Oral Microbiol Immunol 1996: 11: 203-208.
68. Koseki T, Ishikawa I, Umeda M, Benno Y. Characterization of oral treponemes isolated from human periodontal pockets. Oral Microbiol Immunol 1995: 10: 271-277.
69. Krupka HI, Huber R, Holt SC, Clausen T. Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5′-phosphate-dependent protein acting as a haemolytic enzyme. EMBO J 2000: 19: 3168-3178.
70. Lai CH, Listgarten MA, Evian CI, Dougherty P. Serum IgA and IgG antibodies to Treponema vincentii and Treponema denticola in adult periodontitis, juvenile periodontitis, and periodontally healty subjects. J Clin Periodontol 1986: 13: 752-757.
71. Lee SY, Bian XL, Wong GWK, Hannam PM, McBride BC, Fenno JC. Cleavage of Treponema denticola PrcA polypeptide to yield protease complex-associated proteins Prca1 and Prca2 is dependent on PrtP. J Bacteriol 2002: 184: 3864-3870.
72. Lee W, Pankonski L, Zekavat A, Shenker BJ. Treponema denticola immunoinhibitory protein induces irreversible G1 arrest in activated human lymphocytes. Oral Microbiol Immunol 2004: 19: 144-149.
73. Lembariti BS, Mikx FH, van Palenstein Helderman WH. Microscopic spirochete counts in untreated subjects with and without periodontal tissue destruction. J Clin Periodontol 1995: 22: 235-239.
74. Li H, Ruby J, Charon N, Kuramitsu HK. Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant. J Bacteriol 1996: 178: 3664-3667.
75. Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J Periodontol 1976: 47: 1-18.
76. Listgarten MA, Helldén L. Relative distribution of bacteria at clinically healthy and periodontally diseased sites in humans. J Clin Periodontol 1978: 5: 115-132.
77. Listgarten MA, Levin S. Positive correlation between the proportions of subgingival spirochetes and motile bacteria and susceptibility of human subjects to periodontal deterioration. J Clin Periodontol 1981: 8: 122-138.
78. Listgarten MA, Lewis DW. The distribution of spirochetes in the lesion of acute necrotizing ulcerative gingivitis. An electron microscopic and statistical survey. J Periodontol 1967: 38: 379-386.
79. Listgarten MA, Schifter CC, Sullivan P, George C, Rosenberg ES. Failure of a microbial assay to reliably predict disease recurrence in a treated periodontitis population receiving regularly scheduled prophylaxes. J Clin Periodontol 1986: 13: 768-773.
80. Listgarten MA, Socransky SS. Electron microscopy of axial fibrils, outer envelope, and cell division of certain oral spirochetes. J Bacteriol 1964: 88: 1087-1103.
81. Listgarten MA, Socransky SS. Ultrastructural characteristics of a spirochete in the lesion of acute necrotizing ulcerative gingivostomatitis (Vincent's infection). Arch Oral Biol 1964: 9: 95-96.
82. Listgarten MA, Socransky SS. Electron microscopy as an aid in the taxonomic differentiation of oral spirochetes. Arch Oral Biol 1965: 10: 127-138.
83. Listgarten MA, Sullivan P, George C, Nitkin L, Rosenberg ES, Chilton NW, Kramer AA. Comparative longitudinal study of 2 methods of scheduling maintenance visits: 4-year data. J Clin Periodontol 1989: 16: 105-115.
84. Loesche WJ, Bretz WA, Kerschensteiner D, Stoll J, Socransky SS, Hujoel P, Lopatin DE. Development of a diagnostic test for anaerobic periodontal infections based on plaque hydrolysis of benzoyl-DL-arginine-naphthylamide. J Clin Microbiol 1990: 28: 1551-1559.
85. Loesche WJ, Giordano J, Hujoel PP. The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease. J Dent Res 1990: 69: 1696-1702.
86. Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in periodontitis: reduced need for surgery. J Clin Periodontol 1992: 19: 103-112.
87. Loesche WJ, Grossman N, Giordano J. Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. J Clin Periodontol 1993: 20: 96-104.
88. Loesche WJ, Kazor C. Microbiology and treatment of halitosis. Periodontol 2000 2002: 28: 256-279.
89. Loesche WJ, Lopatin DE, Stoll J, van Poperin N, Hujoel P. Comparison of various detection methods for periodontopathic bacteria: can culture be considered the primary reference standard? J Clin Microbiol 1992: 30: 418-426.
90. Lux R, Miller JN, Park N-H, Shi W. Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola. Infect Immun 2001: 69: 6276-6283.
91. Lux R, Sim J-H, Tsai JP, Shi W. Construction and characterization of a cheA mutant of Treponema denticola. J Bacteriol 2002: 184: 3130-3134.
92. Mäkinen KK, Chen CY, Mäkinen PL, Ohta K, Loesche WJ. The benzylarginine peptidase from Treponema denticola (strain ASLM), a human oral spirochete: evidence for active-site carboxyl groups. Mol Microbiol 1990: 4: 1413-1417.
93. Mäkinen PL, Mäkinen KK, Syed SA. An endo-acting proline-specific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides. Infect Immun 1994: 62: 4938-4947.
94. Maltha JC, Mikx FHM, Kuijpers FJ. Necrotizing ulcerative gingivitis in beagle dogs. III. Distribution of spirochetes in interdental gingival tissue. J Periodontal Res 1985: 20: 522-531.
95. Mathers DA, Leung WK, Fenno JC, Hong Y, McBride BC. Major surface protein complex of Treponema denticola depolarizes and induces ion channels in HeLa cell membranes. Infect Immun 1996: 64: 2904-2910.
96. Mikx FHM, Jacobs F, Satumalay C. Cell-bound peptidase activities of Treponema denticola ATCC 33520 in continuous culture. J Gen Microbiol 1992: 138: 1837-1842.
97. Mikx FHM, Maltha JC, van Campen GJ. Spirochetes in early lesions of necrotizing ulcerative gingivitis experimentally induced in beagles. Oral Microbiol Immunol 1990: 5: 86-89.
98. Mikx FHM, Matee MI, Schaeken MJ. The prevalence of spirochetes in the subgingival microbiota of Tanzanian and Dutch children. J Clin Periondontol 1986: 13: 289-293.
99. Moore LV, Moore WEC, Cato EP, Smibert RM, Burmeister JA, Best AM, Ranney RR. Bacteriology of human gingivitis. J Dent Res 1987: 66: 989-995.
100. Moore WEC, Holdeman LV, Cato EP, Smibert RM, Burmeister JA, Palcanis KG, Ranney RR. Comparative bacteriology of juvenile periodontitis. Infect Immun 1985: 48: 507-519.
101. Moore WEC, Holdeman LV, Cato EP, Smibert RM, Burmeister JA, Ranney RR. Bacteriology of moderate (chronic) periodontitis in mature adult humans. Infect Immun 1983: 42: 510-515.
102. Moore WEC, Holdeman LV, Smibert RM, Cato EP, Burmeister JA, Palcanis KG, Ranney RR. Bacteriology of experimental gingivitis in children. Infect Immun 1984: 46: 1-6.
103. Moore WEC, Holdeman LV, Smibert RM, Good IJ, Burmeister JA, Palcanis KG, Ranney RR. Bacteriology of experimental gingivitis in young adult humans. Infect Immun 1982: 38: 651-667.
104. Moore WEC, Holdeman LV, Smibert RM, Hash DE, Burmeister JA, Ranney RR. Bacteriology of severe periodontitis in young adult humans. Infect Immun 1982: 38: 1137-1148.
105. Moore WEC, Moore LH, Ranney RR, Smibert RM, Burmeister JA, Schenkein HA. The microflora of periodontal sites showing active destructive progression. J Clin Periodontol 1991: 18: 729-739.
106. Moter AC, Hoenig BK, Choi BK, Riep B, Göbel UB. Molecular epidemiology of oral treponemes associated with periodontal disease. J Clin Microbiol 1998: 36: 1399-1403.
107. Moter A, Leist G, Rudolph R, Schrank K, Choi B-K, Wagner M, Göbel UB. Fluorescence in situ hybridization shows spatial distribution of as yet uncultured treponemes in biopsies from digital dermatitis lesions. Microbiology 1998: 144: 2459-2467.
108. Mousques T, Listgarten MA, Phillips RW. Effect of scaling and root planing on the composition of the human subgingival microbial flora. J Periodontal Res 1980: 15: 144-151.
109. Narikiyo M, Tanabe C, Yamada Y, Igaki H, Tachimori Y, Kato H, Muto M, Montesano R, Sakamoto H, Nakajima Y, Sasaki H. Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers. Cancer Sci 2004: 95: 569-574.
110. Newman HN. The apical border of plaque in chronic inflammatory periodontal disease. Br Dent J 1976: 141: 105-113.
111. Newman HN. Plaque and chronic inflammatory periodontal disease. A question of ecology. J Clin Periodontol 1990: 17: 533-541.
112. Nilius AM, Spencer SC, Simonson LG. Stimulation of in vitro growth of Treponema denticola by extracellular growth factors produced by Porphyromonas gingivalis. J Dent Res 1993: 72: 1027-1031.
113. Nixon CS, Steffen MJ, Ebersole JL. Cytokine responses to Treponema pectinovorum and Treponema denticola in human gingival fibroblasts. Infect Immun 2000: 68: 5284-5292.
114. Noiri Y, Li L, Ebisu S. The localization of periodontal disease-associated bacteria in human periodontal pockets. J Dent Res 2001: 80: 1930-1934.
115. Opitz B, Schröder NWJ, Spreitzer I, Michelsen KS, Kirschning CJ, Hallatschek W, Zähringer U, Hartung T, Göbel UB. Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-κB translocation. J Biol Chem 2001: 276: 22041-22047.
116. Paes Batista da Silva A, Lee W, Bajenova E, McCulloch CAG, Ellen RP. The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts. Cell Microbiol 2004: 6: 485-498.
117. Paster BJ, Boches SK, Galvin JL, Ericson RE, Lau CN, Levanos VA, Sahasrabudhe A, Dewhirst FE. Bacterial diversity in human subgingival plaque. J Bacteriol 2001: 183: 3770-3783.
118. Paster BJ, Dewhirst FE, Coleman BC, Lau CN, Ericson RL. Phylogenetic analysis of cultivable oral treponemes from the Smibert collection. Int J Syst Bacteriol 1998: 48: 713-722.
119. Pederson ED, Miller JW, Matheson S, Simonson LG, Chadwick DE, Coy PJ, Turner DW, Lamberts BL, Morton HE. Trypsin-like activity levels of Treponema denticola and Porphyromonas gingivalis in adults with periodontitis. J Clin Periodontol 1994: 21: 519-525.
120. Qui Y-S, Klitorinos A, Rahal MD, Siboo R, Chan ECS. Enumeration of viable oral spirochetes from periodontal pockets. Oral Microbiol Immunol 1994: 9: 301-304.
121. Rams TE, Keyes PH. A rationale for the management of periodontal diseases: effects of tetracycline on subgingival bacteria. J Am Dent Assoc 1983: 107: 37-41.
122. Riviere GR, DeRouen TA. Association of oral spirochetes from periodontally healthy sites with development of gingivitis. J Periodontol 1998: 69: 496-501.
123. Riviere GR, DeRouen TA, Kay SL, Avera SP, Stouffer VK, Hawkins NR. Association of oral spirochetes from sites of periodontal health and development of periodontitis. J Periodontol 1997: 68: 1210-1214.
124. Riviere GR, Riviere GR, Smith KS. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral Microbiol Immunol 2002: 17: 113-118.
125. Riviere GR, Smith KS, Carranza N Jr, Tzagaroulaki E, Kay SL, Dock M. Subgingival distribution of Treponema denticola, Treponema socranskii, and pathogen-related oral spirochetes: prevalence and relationship to periodontal status of sample sites. J Periodontol 1995: 66: 829-837.
126. Riviere GR, Smith KS, Carranza N Jr, Tzagaroulaki E, Kay SL, Dock M, Zhu X, DeRouen TA. Associations between Porphyromonas gingivalis and oral treponemes in subgingival plaque. Oral Microbiol Immunol 1996: 11: 150-155.
127. Riviere GR, Smith KS, Willis SG, Riviere KH. Phenotypic and genotypic heterogeneity among cultivable pathogen-related oral spirochetes and Treponema vincentii. J Clin Microbiol 1999: 37: 3676-3680.
128. Riviere GR, Thompson AJ, Brannan RD, McCoy DE, Simonson LG. Detection of pathogen-related oral spirochetes, Treponema denticola, and Treponema socranskii in dental plaque from dogs. J Vet Dent 1996: 13: 135-138.
129. Riviere GR, Wagoner MA, Baker-Zander SA, Weisz KS, Adams DF, Simonson L, Lukehart SA. Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. N Engl J Med 1991: 325: 539-543.
130. Riviere GR, Weisz KS, Adams DF, Thomas DD. Pathogen-related oral spirochetes from dental plaque are invasive. Infect Immun 1991: 59: 3377-3380.
131. Riviere GR, Weisz KS, Simonson LG, Lukehart SA. Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis. Infect Immun 1991: 59: 2653-2657.
132. Rosen G, Naor R, Rahamim E, Yishai R, Sela MN. Proteases of Treponema denticola outer sheath and extracellular vesicles. Infect Immun 1995: 63: 3973-3979.
133. Rosen G, Sela MN, Naor R, Halabi A, Barak V, Shapira L. Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola. Infect Immun 1999: 67: 1180-1186.
134. Saglie FR, Carranza FA Jr, Newman MG. The presence of bacteria within the oral epithelium in periodontal disease. I. Scanning and transmission electron microscopic study. J Periodontol 1985: 56: 618-624.
135. Saglie FR, Newman MG, Carranza FA Jr, Pattison GL. Bacterial invasion of gingival in advanced periodontitis in humans. J Periodontol 1982: 53: 217-222.
136. Sakamoto M, Huang Y, Ohnishi M, Umeda M, Ishikawa I, Benno Y. Changes in oral microbial profiles after periodontal treatment as determined by molecular analysis of 16S rRNA genes. J Med Microbiol 2004: 53: 653-671.
137. Schultz CP, Wolf V, Lange R, Mertens E, Wecke J, Naumann D, Zahringer U. Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides. J Biol Chem 1998: 273: 15661-15666.
138. Scott D, Siboo R, Chan ECS, Siboo R. An extracellular enzyme with hyaluronidase and chondroitinase activities from some oral anaerobic spirochetes. Microbiology 1996: 142: 2567-2576.
139. Sela MN. Role of Treponema denticola in periodontal diseases. Crit Rev Oral Biol Med 2001: 12: 399-413.
140. Sela MN, Bolotin A, Naor R, Weinberg A, Rosen G. Lipoproteins of Treponema denticola: their effect on human polymorphonuclear neutrophils. J Periodontal Res 1997: 32: 455-466.
141. Sela MN, Kornman KS, Ebersole JL, Holt SC. Characterization of treponemes isolated from human and nonhuman primate periodontal pockets. Oral Microbiol Immunol 1987: 2: 21-29.
142. Sela MN, Weinberg A, Borinsky R, Holt SC, Dishon T. Inhibition of superoxide production in human polymorphonuclear leukocytes by oral treponemal factors. Infect Immun 1988: 56: 589-594.
143. Seshadri RGS, Myers GSH, Tettlelin H, Eisen JA, Heidelberg JF, Dodson RJ, Davidsen TM, DeBoy RT, Fouts DE, Haft DH, Selengut J, Ren Q, Brinkac LM, Madupu R, Kolonay J, Durkin SA, Daugherty SC, Shetty J, Shvartsbeyn A, Gebregeorgis E, Geer K, Tsegaye G, Malek J, Ayodeji B, Shatsman S, McLeod MP, Smajs D, Howell JK, Pal S, Amin A, Vashisth P, McNeill TZ, Xiang Q, Sodergren E, Baca E, Weinstock GM, Norris SJ, Fraser CM, Paulsen IT. Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc Natl Acad Sci U S A 2004: 101: 5646-5651.
144. Shenker BJ, Listarten MA, Taichman NS. Suppression of human lymphocyte responses by oral spirochetes, a monocyte-dependent phenomenon. J Immunol 1984: 132: 2039-2045.
145. Simonson LG, Goodman CH, Bial JJ, Morton HE. Quantitative relationship of Treponema denticola to severity of periodontal disease. Infect Immun 1988: 56: 726-728.
146. Simonson LG, Goodman CH, Morton HE. Quantitative immunoassay of Treponema denticola serovar C in adult periodontitis. J Clin Microbiol 1990: 28: 1493-1496.
147. Simonson LG, McMahon KT, Childers DW, Morton HE. Bacterial synergy of Treponema denticola and Porphyromonas gingivalis in a multinational population. Oral Microbiol Immunol 1992: 7: 111-112.
148. Simonson LG, Robinson PJ, Pranger RJ, Cohen ME, Morton HE. Treponema denticola and Porphyromonas gingivalis as prognostic markers following periodontal treatment. J Periodontol 1992: 63: 270-273.
149. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol 1979: 50: 495-509.
150. Smibert RM. Genus III. Treponema Schaudinn 1905, 1728AL. In: Krieg NR, Holt JG, editors. Bergey's Manual of Systematic Bacteriology, Vol. 1. Baltimore: Williams & Wilkins, 1984: 49-57.
151. Smibert RM, Burmeister JA. Treponema pectinovorum sp. nov., isolated from humans with periodontitis. Int J Syst Bacteriol 1983: 33: 852-856.
152. Smibert RM, Johnson JL, Ranney RR. Treponema socranskii sp. nov., Treponema socranskii subsp. socranskii subsp. nov., Treponema socranskii subsp. buccale subsp. nov., Treponema socranskii subsp. paredis subsp. nov., isolated from the human periodontia. Int J Syst Bacteriol 1984: 34: 457-462.
153. Soames JV, Davies RM. The structure of subgingival plaque in a beagle dog. J Periodontal Res 1974: 9: 333-341.
154. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000 1994: 5: 7-25.
155. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002: 28: 12-55.
156. Socransky SS, Haffajee AD, Gugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998: 25: 134-144.
157. Socransky S, Haffajee A, Smith C, Dibart S. Relation of counts of microbial species to clinical status at the site. J Clin Periodontol 1991: 18: 766-775.
158. Socransky SS, Smith C, Haffajee AD. Subgingival microbial profiles in refractory periodontal disease. J Clin Periodontol 2002: 29: 260-268.
159. Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, Saari H, Uitto V-J. Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect Immun 1992: 60: 4491-4495.
160. Syed SA, Svanberg M, Svanberg G. The predominant cultivable dental plaque flora of beagle dogs with periodontitis. J Clin Periodontol 1981: 8: 45-56.
161. Takeuchi Y, Umeda M, Ishizuka M, Huang Y, Ishikawa I. Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population. J Periodontol 2003: 74: 1460-1469.
162. Takeuchi Y, Umeda M, Sakamoto M, Benno Y, Huang Y, Ishkawa I. Treponema socranskii, Treponema denticola, and Porphyromonas gingivalis associated with severity of periodontal tissue destruction. J Periodontol 2001: 72: 1354-1363.
163. Tew JG, Smibert RM, Scott EA, Burmeister JA, Ranney RR. Serum antibodies in young adult humans reactive with periodontitis associated treponemes. J Periodontal Res 1985: 20: 580-590.
164. Torresyap G, Haffajee AD, Uzel NG, Socransky SS. Relationship between periodontal pocket sulfide levels and subgingival species. J Clin Periodontol 2003: 30: 1003-1010.
165. Uitto V-J, Grenier D, Chan EC, McBride BC. Isolation of a chymotrypsin-like enzyme from Treponema denticola. Infect Immun 1988: 56: 2717-2722.
166. Uitto V-J, Pan Y-M, Leung WK, Larjava H, Ellen RP, Finlay BB, McBride BC. Cytopathic effects of Treponema denticola chymotrypsin-like protease on migrating and stratified epithelial cells. Infect Immun 1995: 63: 3401-3410.
167. Umeda M, Ishikawa I, Benno Y, Mitsuoka T. Improved detection of oral spirochetes in an anaerobic culture method. Oral Microbiol Immunol 1990: 5: 90-94.
168. Umemoto T, Nakazawa F, Hoshino E, Okada K, Fukunaga M, Namikawa I. Treponema medium sp. nov., isolated from human subgingival dental plaque. Int J Syst Bacteriol 1997: 47: 67-72.
169. Valdez M, Haines R, Riviere KH, Riviere GR, Thomas DD. Isolation of oral spirochetes from dogs and cats and provisional identification using polymerase chain reaction (PCR) analysis specific for human plaque Treponema spp. J Vet Dent 2000: 17: 23-26.
170. Van Horn KG, Smibert RM. Fatty acid requirement of Treponema denticola and Treponema vincentii. Can J Microbiol 1982: 28: 344-350.
171. Vesey PM, Kuramitsu HK. Genetic analysis of Treponema denticola ATCC 35405 biofilm formation. Microbiology 2004: 150: 2401-2407.
172. Wang Q, Ko KS, Kapus A, McCulloch CAG, Ellen RP. A spirochete surface protein uncouples store-operated calcium channels in fibroblasts. J Biol Chem 2001: 276: 233056-223064.
173. Washizu M, Ishihara K, Honma K, Okuda K. Effects of a mixed infection with Porphyromonas gingivalis and Treponema denticola on abscess formation and immune responses in mice. Bull Tokyo Dent Coll 2003: 44: 141-147.
174. Weinberg A, Holt SC. Interaction of Treponema denticola TD-4, GM-1, and MS25 with human gingival fibroblasts. Infect Immun 1990: 58: 1720-1729.
175. Weinberg A, Holt SC. Chemical and biological activities of a 64-kilodalton outer sheath protein from Treponema denticola strains. J Bacteriol 1991: 173: 6935-6947.
176. Willis SG, Smith KS, Dunn VL, Gapter LA, Riviere KH, Riviere GR. Identification of seven Treponema species in health- and disease-associated dental plaque by nested PCR. J Clin Microbiol 1999: 37: 867-869.
177. Wyss C, Choi BK, Schüpbach P, Guggenheim B, Göbel UB. Treponema maltophilum sp. nov., a small oral spirochete isolated from human periodontal lesions. Int J Syst Bacteriol 1996: 46: 745-752.
178. Wyss C, Choi BK, Schüpbach P, Guggenheim B, Göbel UB. Treponema amylovorum sp. nov., a saccharolytic spirochete of medium size isolated from and advanced human periodontal lesion. Int J Syst Bacteriol 1997: 47: 842-845.
179. Wyss C, Choi BK, Schüpbach P, Moter A, Guggenheim B, Göbel UB. Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases. Int J Syst Bacteriol 1999: 49: 1329-1339.
180. Wyss C, Dewhirst FE, Gmür R, Thurnheer T, Xue Y, Schüpbach P, Guggenheim B, Paster BJ. Treponema parvum sp. nov., a small, glucoronic or galacturonic acid-dependent oral spirochaete from lesions of human periodontitis and acute necrotizing ulcerative gingivitis. Int J Syst Evol Microbiol 2001: 51: 955-962.
181. Wyss C, Moter A, Choi BK, Dewhirst FE, Xue Y, Schüpbach P, Göbel U, Paster BJ, Guggenheim B. Treponema putidum sp. nov. a medium-sized proteolytic spirochaete isolated from lesions of human periodontitits and acute necrotizing ulcerative gingivitis. Int J Syst Evol Microbiol 2004: 54: 1117-1122.
182. Yang PF, Song M, Grove DA, Ellen RP. Filamentous actin disruption and diminished inositol phosphate response in gingival fibroblasts caused by Treponema denticola. Infect Immun 1998: 66: 696-702.
183. Yoshida A, Kawada M, Suzuki N, Nakano Y, Oho T, Saito T, Yamashita Y. TaqMan real-time polymerase chain reaction assay for the correlation of Treponema denticola numbers with the severity of periodontal disease. Oral Microbiol Immunol 2004: 19: 196-200.