Local gene transfer to modulate rat corneal allograft rejection

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 5, 2005, Pages 1675-1681

  Jessup, Claire F ^a   Brereton, Helen M ^a   Sykes, Pamela J ^a   Thiel, Michael A ^b   Coster, Douglas J ^a   Williams, Keryn A ^a,c  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; COMPLEMENTARY DNA; ENHANCED GREEN FLUORESCENT PROTEIN; OKT 4; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESSENGER RNA; PHOTOPROTEIN; SCFV GREEN FLUORESCENT PROTEIN, RECOMBINANT;

ADENOVIRUS VECTOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CORNEA ENDOTHELIUM; CORNEA TRANSPLANTATION; DNA TRANSFER; DRUG ACTIVITY; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSTIMULATION; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION; WESTERN BLOTTING; ADENOVIRUS; ALLOTRANSPLANTATION; ANIMAL; CELL PROLIFERATION; CORNEA; FISCHER 344 RAT; FLUORESCENCE MICROSCOPY; GENE TRANSFER; GENE VECTOR; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MIXED LYMPHOCYTE CULTURE; WISTAR FURTH RAT;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CORNEA; CORNEAL TRANSPLANTATION; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GRAFT REJECTION; GRAFT SURVIVAL; GREEN FLUORESCENT PROTEINS; IMMUNOGLOBULIN VARIABLE REGION; LUMINESCENT PROTEINS; LYMPHOCYTE CULTURE TEST, MIXED; MICROSCOPY, FLUORESCENCE; RATS; RATS, INBRED F344; RATS, INBRED WF; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSPLANTATION, HOMOLOGOUS;

EID: 20444434298     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-1140     Document Type: Article

References (54)

1. Williams KA, Roder D, Esterman A, Muehlberg SM, Coster DJ. Factors predictive of corneal graft survival: report from the Australian Corneal Graft Registry. Ophthalmology. 1992;99:403-414.
2. Konig R, Huang LY, Germain RN. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature. 1992;356:796-798.
3. Cammarota G, Scheirle A, Takacs B, et al. Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules. Nature. 1992;356:799-801.
4. Xu H, Littman DR. A kinase-independent function of Lck in potentiating antigen-specific T cell activation. Cell. 1993;74:633-643.
5. Benjamin RJ, Waldmann H. Induction of tolerance by monoclonal antibody therapy. Nature. 1986;320:449-451.
6. Cosimi AB, Burton RC, Kung PC, et al. Evaluation in primate renal allograft recipients of monoclonal antibody to human T cell subclasses. Transplant Proc. 1981;13:499-503.
7. Sablinski T, Hancock WW, Tilney NL, Kupiec-Weglinski JW. CD4 monoclonal antibodies in organ transplantation: a review of progress. Transplantation. 1991;52:579-589.
8. Cobbold SP, Martin G, Qin S, Waldmann H. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature. 1986;323:164-166.
9. Thiel MA, Takano T, Hawksworth N, Coster DJ, Williams KA. Low-dose, short-term treatment with anti-CD4 monoclonal antibody prolongs corneal allograft survival. Transplant Proc. 2001; 33:635-636.
10. Pleyer U, Milani JK, Dukes A, et al. Effect of topically applied anti-CD4 monoclonal antibodies on orthotopic corneal allografts in a rat model. Invest Ophthalmol Vis Sci. 1995;36:52-61.
11. Ayliffe W, Alam Y, Bell EB, McLeod D, Hutchinson IV. Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody. Br J Ophthalmol. 1992;76:602-606.
12. He YG, Ross J, Niederkorn JY. Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody. Invest Ophthalmol Vis Sci. 1991;32:2723-2728.
13. Chatenoud L, Bach JF. Therapeutic monoclonal antibodies in transplantation. Transplant Proc. 1993;25:473-474.
14. Bach JF, Fracchia GN, Chatenoud L. Safety and efficacy of therapeutic monoclonal antibodies in clinical therapy. Immunol Today. 1993;14:421-425.
15. Ippoliti G, Fronterre A. Usefulness of CD3 or CD6 anti-T monoclonal antibodies in the treatment of acute corneal graft rejection. Transplant Proc. 1989;21:3133-3134.
16. Allansmith M, de Ramus A, Maurice D. The dynamics of IgG in the cornea. Invest Ophthalmol Vis Sci. 1979;18:947-955.
17. Abraham NG, da Silva JL, Lavrovsky Y, et al. Adenovirus-mediated heme oxygenase-1 gene transfer into rabbit ocular tissues. Invest Ophthalmol Vis Sci. 1995;36:2202-2210.
18. Lai CM, Spilsbury K, Brankov M, Zaknich T, Rakoczy PE. Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA. Exp Eye Res. 2002;75:625-634.
19. Hoffman LM, Maguire AM, Bennett J. Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery. Invest Ophthalmol Vis Sci. 1997;38: 2224-2233.
20. Klebe S, Sykes PJ, Coster DJ, Bloom DC, Williams KA. Gene transfer to ovine corneal endothelium. Clin Exp Ophthalmol. 2001;29:316-322.
21. Borras T, Gabelt BT, Klintworth GK, Peterson JC, Kaufman PL. Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in vivo. J Gene Med. 2001;3:437-449.
22. Larkin DF, Oral HB, Ring CJ, Lemoine NR, George AJ. Adenovirus-mediated gene delivery to the corneal endothelium. Transplantation. 1996;61:363-370.
23. Thiel MA, Coster DJ, Standfield SD, et al. Penetration of engineered antibody fragments into the eye. Clin Exp Immunol. 2002;128: 67-74.
24. Sadlon TA, Parker SJ, Gordon DL. Regulation of C3 deposition on gp120 coated CD4 positive cells by decay accelerating factor and factor H. Immunol Cell Biol. 1994;72:461-470.
25. He TC, Zhou S, da Costa LT, et al. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA. 1998; 95:2509-2514.
26. Graham FL, Prevec L. Methods for construction of adenovirus vectors. Mol Biotechnol. 1995;3:207-220.
27. Kanegae Y, Makimura M, Saito I. A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol. 1994;47:157-166.
28. Nyberg-Hoffman C, Shabram P, Li W, Giroux D, Aguilar-Cordova E. Sensitivity and reproducibility in adenoviral infectious titer determination. Nat Med. 1997;3:808-811.
29. Plain KM, Chen J, Merten S, He XY, Hall BM. Induction of specific tolerance to allografts in rats by therapy with non-mitogenic, non-depleting anti-CD3 monoclonal antibody: association with TH2 cytokines not anergy. Transplantation. 1999;67:605-613.
30. Williams KA, Coster DJ. Penetrating corneal transplantation in the inbred rat: a new model. Invest Ophthalmol Vis Sci. 1985;26:23-30.
31. Inabe K, Steinman RM. Monoclonal antibodies to LFA-1 and to CD4 inhibit the mixed leukocyte reaction after the antigen-dependent clustering of dendritic cells and T lymphocytes. J Exp Med. 1987; 165:1403-1417.
32. Pelegri C, Castell M, Serra M, et al. Prevention of adjuvant arthritis by the W3/25 anti-CD4 monoclonal antibody is associated with a decrease of blood CD4(+)CD45RC(high) T cells. Clin Exp Immunol. 2001;125:470-477.
33. Zhang Z, Zhang Y, Zhu H, Yang J, Shen G. CD4+ T cell apoptosis induced by anti-CD4 antibodies. J Tongji Med Univ. 2000;20:100-102.
34. Waldmann H, Cobbold S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annu Rev Immunol. 1998;16:619-644.
35. Hall BM, Fava L, Chen J, et al. Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ suppressor T cells that are not dependent upon IL-4. J Immunol. 1998;161:5147-5156.
36. Read S, Powrie F. CD4(+) regulatory T cells. Curr Opin Immunol. 2001;13:644-649.
37. Sawitzki B, Lehmann M, Vogt K, et al. Bag-1 up-regulation in anti-CD4 mAb-treated allo-activated T cell confers resistance to activation-induced cell death (AICD). Transpl Immunol. 2002;9: 83-91.
38. Yin D, Fathman CG. CD4-positive suppressor cells block allotransplant rejection. J Immunol. 1995;154:6339-6345.
39. Pullar CE, Morris PJ, Wood KJ. Altered proximal T-cell receptor signalling events in mouse CD4+ T cells in the presence of anti-CD4 monoclonal antibodies: evidence for reduced phosphorylation of Zap-70 and LAT. Scand J Immunol. 2003;57:333-341.
40. Stumbles P, Mason D. Activation of CD4+ T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J Exp Med. 1995;182:5-13.
41. Fehervari Z, Cooke A, Brett S, Turner J. Perturbation of naive TCR transgenic T cell functional responses and upstream activation events by anti-CD4 monoclonal antibodies. Eur J Immunol. 2002; 32:333-340.
42. Bank I, Chess L. Perturbation of the T4 molecule transmits a negative signal to T cells. J Exp Med. 1985;162:1294-1303.
43. Horneff G, Guse AH, Schulze-Koops H, et al. Human CD4 modulation in vivo induced by antibody treatment. Clin Immunol Immunopathol. 1993;66:80-90.
44. Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR. Draining lymph nodes of corneal transplant hosts exhibits evidence for donor major histocompatibility complex (MHC) Class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med. 2002;195:259-268.
45. McMenamin PG, Djano J, Wealthall R, Griffin BJ. Characterization of the macrophages associated with the tunica vasculosa lentis of the rat eye. Invest Ophthalmol Vis Sci. 2002;43:2076-2082.
46. Banerjee S, Figueiredo FC, Easty DL, Dick AD, Nicholls SM. Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats. Br J Ophthalmol. 2003;87:1515-1522.
47. Liu Y, Dana MR, Tewari V, Taylor AW. Immune response to intragraft antigen in draining lymph nodes after corneal transplantation is mediated by interleukin-12. J Interferon Cytokine Res. 2001;21:813-819.
48. Hoffmann F, Zhang EP, Mueller A, et al. Contribution of lymphatic drainage system in corneal allograft rejection in mice. Graefes Arch Clin Exp Ophthalmol. 2001;239:850-858.
49. Yamagami S, Amano S. Role of resident corneal leukocytes and draining cervical lymph nodes in corneal allograft rejection. Cornea. 2003;22:S61-S65.
50. Yamagami S, Dana MR. The critical role of lymph nodes in corneal alloimmunization and graft rejection. Invest Ophthalmol Vis Sci. 2001;42:1293-1298.
51. Hamrah P, Liu Y, Zhang Q, Dana MR. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci. 2003;44:581-589.
52. Brissette-Storkus CS, Reynolds SM, Lepisto AJ, Hendricks RL. Identification of a novel macrophage population in the normal mouse corneal stroma. Invest Ophthalmol Vis Sci. 2002;43:2264-2271.
53. Klebe S, Sykes PJ, Coster DJ, Krishnan R, Williams KA. Prolongation of sheep corneal allograft survival by ex vivo transfer of the gene encoding interleukin-10. Transplantation. 2001;71:1214-1220.
54. Comer RM, King WJ, Ardjomand N, et al. Effect of administration of CTLA4-Ig as protein or cDNA on corneal allograft survival. Invest Ophthalmol Vis Sci. 2002;43:1095-1103.