Penetration of engineered antibody fragments into the eye

Clinical and Experimental Immunology

Volumn 128, Issue 1, 2002, Pages 67-74

  Thiel, M A ^a,d   Coster, D J ^a   Standfield, S D ^a   Brereton, H M ^a   Mavrangelos, C ^b   Zola, H ^b   Taylor, S ^c   Yusim, A ^c   Williams, K A ^a,e  

^a FLINDERS UNIVERSITY   (Australia)

^b CHILD HEALTH RESEARCH INSTITUTE   (Australia)

^c Research and Molecular Development   (Australia)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Cornea; Engineered antibody fragments; Immunotherapeutics

Indexed keywords

MONOCLONAL ANTIBODY; PROTEINASE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SODIUM DERIVATIVE;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ANTIGEN BINDING; ARTICLE; BIOENGINEERING; CAT; CONTROLLED STUDY; CORNEA; EYE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES DIFFERENCE; SWINE; TARGET CELL;

ANIMALS; CATS; CELLS, CULTURED; CORNEA; CULTURE TECHNIQUES; DECANOIC ACIDS; EPITHELIUM, CORNEAL; EYE; EYE DISEASES; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; JURKAT CELLS; KINETICS; MOLECULAR WEIGHT; PERFUSION; PROTEIN ENGINEERING; PROTEIN TRANSPORT; RATS; SWINE;

EID: 0036247783     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01808.x     Document Type: Article

References (35)

1. Treatment of acute renal allograft rejection with OKT3 monoclonal antibody
2. Therapeutic monoclonal antibodies
3. Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody
4. Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody
5. Treatment of endogenous uveitis with anti-CD4 monoclonal antibody: First report
6. Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H
7. Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection
8. Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye
9. The dynamics of IgG in the cornea
10. Recombinant antibody fragments
11. New protein engineering approaches to multivalent and bispecific antibody fragments
12. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
13. Single chain antigen binding protein (sFv CC49). First human studies in colorectal carcinoma metastatic to liver
14. Enhancement of ocular drug penetration
15. The formulation of drug for ocular administration
16. Clinical pharmacokinetics of the eye
17. Ocular pharmacokinetics
18. Increased corneal permeability induced by the dual effects of transient tear film acidification and exposure to benzalkonium chloride
19. Ophthalmic preservatives as absorption promoters for ocular drug delivery
20. The influence of non-ionic detergents and other surfactants on human corneal permeability
21. Effects of four penetration enhancers on corneal permeability of drugs in vitro
22. Different effects of absorption promoters on corneal and conjunctival penetration of ophthalmic beta-blockers
23. Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages
24. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system
25. Improved bivalent minianti-bodies, with identical avidity as whole antibodies, produced by high cell density fermentation of Escherichia coli
26. Producing antibodies in Escherichia coli: From PCR to fermentation
27. Three-step purification of lipopolysaccharide-free, polyhistidine-tagged recombinant antigens of Mycobacterium tuberculosis
28. A simple corneal perfusion chamber for drug penetration and toxicity studies
29. In vitro incubation of rabbit cornea
30. Detection by immunofluorescence of surface molecules present in low copy numbers. High sensitivity staining and calibration of flow cytometer
31. Solute permeability of the corneal endothelium and Descemet's membrane
32. Reversible increase in tight junction permeability to macromolecules in rat ileal mucosa in vitro by sodium caprate, a constituent of milk fat
33. Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas
34. Different effects of absorption promoters on corneal and conjunctival penetration of ophthalmic beta-blockers
35. Studies on improved corneal permeability to bunazosin