Jα-gene segment usage and the CDR3 diversity of porcine TCRα-chain cDNA clones from the PBL of a five-month-old pig and the thymus of a one-month-old pig

Molecular Immunology

Volumn 42, Issue 11, 2005, Pages 1375-1383

  Yamamoto, Ryuji ^a,b,c   Uenishi, Hirohide ^a   Hatsuse, Hiromi ^b   Sato, Eimei ^c   Awata, Takashi ^a   Yasue, Hiroshi ^a   Takagaki, Yohtaroh ^b  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Complementarity determining region3 (CDR3); J gene segments; Porcine peripheral blood lymphocytes (PBL); Porcine thymus; T cell receptor; V gene segments

Indexed keywords

AMINO ACID DERIVATIVE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; COMPLEMENTARY DNA; IMMUNOGLOBULIN J CHAIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA ISOLATION; DNA LIBRARY; FEMALE; GENE CLUSTER; GENE DUPLICATION; GENE IDENTIFICATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC VARIABILITY; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; THYMUS; AMINO ACID SEQUENCE; ANIMAL; COMPLEMENTARITY DETERMINING REGION; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE; MOLECULAR GENETICS; MOUSE; SPECIES DIFFERENCE;

MURINAE; SUIDAE; SUS SCROFA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; COMPLEMENTARITY DETERMINING REGIONS; DNA, COMPLEMENTARY; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; IMMUNOGLOBULIN J-CHAINS; LYMPHOCYTES; MICE; MOLECULAR SEQUENCE DATA; SPECIES SPECIFICITY; SUS SCROFA; SWINE; THYMUS GLAND; VARIATION (GENETICS);

EID: 20444411143     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2004.12.015     Document Type: Article

References (42)

1. C. Baron, I. McMorrow, D.H. Sachs, and C. LeGuern Persistence of dominant T cell clones in accepted solid organ transplants J. Immunol. 167 2001 4154 4160
2. R.M. Binns, I.A. Duncan, S.J. Powis, A. Hutchings, and G.W. Butcher Subsets of null and γδ T-cell receptor + T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies Immunology 77 1992 219 227
3. J.E. Butler, J. Sun, and P. Navarro The swine Ig heavy chain locus has a single JH and no identifiable IgD Int. Immunol. 8 1996 1897 1904
4. P. Chardon, C. Renard, and M. Vaiman The major histocompatibility complex in swine Immunol. Rev. 167 1999 179 192
5. M.M. Davis T cell receptor gene diversity and selection Annu. Rev. Biochem. 59 1990 475 496
6. M.M. Davis, and P.J. Bjorkman T-cell antigen receptor genes and T-cell recognition Nature 334 1988 395 402
7. M.M. Davis, J.J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien Ligand recognition by αβ T cell receptors Annu. Rev. Immunol. 16 1998 523 544
8. F. Davodeau, M. Difilippantonio, E. Roldan, M. Malissen, J.L. Casanova, C. Couedel, J.F. Morcet, M. Merkenschlager, A. Nussenzweig, M. Bonneville, and B. Malissen The tight interallelic positional coincidence that distinguishes T-cell receptor Jα usage does not result from homologous chromosomal pairing during VαJα rearrangement EMBO J. 20 2001 4717 4729
9. R. de Chasseval, and J.P. de Villartay Functional characterization of the promoter for the human germ-line T cell receptor Jα (TEA) transcript Eur. J. Immunol. 23 1993 1294 1298
10. V. Dufour, S. Malinge, and F. Nau The sheep Ig variable region repertoire consists of a single VH family J. Immunol. 156 1996 2163 2170
11. K.C. Garcia, L. Teyton, and I.A. Wilson Structural basis of T cell recognition Annu. Rev. Immunol. 17 1999 369 397
12. P. Gianello, J.M. Fishbein, and D.H. Sachs Tolerance to primarily vascularized allografts in miniature swine Immunol. Rev. 133 1993 19 44
13. S. Gilfillan, A. Dierich, M. Lemeur, C. Benoist, and D. Mathis Mice lacking TdT: mature animals with an immature lymphocyte repertoire Science 261 1993 1175 1178
14. J. Guo, A. Hawwari, H. Li, Z. Sun, S.K. Mahanta, D.R. Littman, M.S. Krangel, and Y.W. He Regulation of the TCR α repertoire by the survival window of CD4(+)CD8(+) thymocytes Nat. Immunol. 3 2002 469 476
15. W.R. Hein, and C.R. Mackay Prominence of γδ T cells in the ruminant immune system Immunol. Today 12 1991 30 34
16. C. Huang, and O. Kanagawa Ordered and coordinated rearrangement of the TCR α locus: role of secondary rearrangement in thymic selection J. Immunol. 166 2001 2597 2601
17. E.A. Kabat, T.T. Wu, H.M. Perry, K.S. Gottesman, and C. Foeller Sequences of Proteins of Immunological Interest 1991 U.S. Deptartment of Health and Human services Washington, DC
18. T. Komori, A. Okada, V. Stewart, and F.W. Alt Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes Science 261 1993 1171 1175
19. B.F. Koop, and L. Hood Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA Nat. Genet. 7 1994 48 53
20. B.F. Koop, L. Rowen, K. Wang, C.L. Kuo, D. Seto, J.A. Lenstra, S. Howard, W. Shan, P. Deshpande, and L. Hood The human T-cell receptor TCRAC/TCRDC (Cα/Cδ) region: organization, sequence, and evolution of 97.6 kb of DNA Genomics 19 1994 478 493
21. J.J. Lafaille, A. DeCloux, M. Bonneville, Y. Takagaki, and S. Tonegawa Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining Cell 59 1989 859 870
22. E. Lai, R.K. Wilson, and L.E. Hood Physical maps of the mouse and human immunoglobulin-like loci Adv. Immunol. 46 1989 1 59
23. T. Maniatis, E.F. Fritseh, and J. Sambrook Molecular Cloning: A Laboratory Manual 1982 Cold Spring Harbor Laboratory NY
24. N. Pasqual, M. Gallagher, C. Aude-Garcia, M. Loiodice, F. Thuderoz, J. Demongeot, R. Ceredig, P.N. Marche, and E. Jouvin-Marche Quantitative and qualitative changes in V-Jα rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor α chain repertoire J. Exp. Med. 196 2002 1163 1173
25. E.P. Rock, P.R. Sibbald, M.M. Davis, and Y.H. Chien CDR3 length in antigen-specific immune receptors J. Exp. Med. 179 1994 323 328
26. M.A. Rytkonen, J.L. Hurwitz, S.D. Thompson, and J. Pelkonen Restricted onset of T cell receptor α gene rearrangement in fetal and neonatal thymocytes Eur. J. Immunol. 26 1996 1892 1896
27. H. Schild, N. Mavaddat, C. Litzenberger, E.W. Ehrich, M.M. Davis, J.A. Bluestone, L. Matis, R.K. Draper, and Y.H. Chien The nature of major histocompatibility complex recognition by γδ T cells Cell 76 1994 29 37
28. M.C. Sinclair, J. Gilchrist, and R. Aitken Bovine IgG repertoire is dominated by a single diversified VH gene family J. Immunol. 159 1997 3883 3889
29. M. Sinkora, J. Sun, and J.E. Butler Antibody repertoire development in fetal and neonatal piglets. V. VDJ gene chimeras resembling gene conversion products are generated at high frequency by PCR in vitro Mol. Immunol. 37 2000 1025 1034
30. J. Sun, I. Kacskovics, W.R. Brown, and J.E. Butler Expressed swine VH genes belong to a small VH gene family homologous to human VHIII J. Immunol. 153 1994 5618 5627
31. A. Thome, A. Saalmuller, and E. Pfaff Molecular cloning of porcine T cell receptor α, β, γ and δ chains using polymerase chain reaction fragments of the constant regions Eur. J. Immunol. 23 1993 1005 1010
32. S.D. Thompson, J. Pelkonen, and J.L. Hurwitz First T cell receptor α gene rearrangements during T cell ontogeny skew to the 5′ region of the Jα locus J. Immunol. 145 1990 2347 2352
33. S. Tonegawa Somatic generation of antibody diversity Nature 302 1983 575 581
34. Y. Uematsu, S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes Cell 52 1988 831 841
35. H. Uenishi, H. Hiraiwa, R. Yamamoto, H. Yasue, Y. Takagaki, T. Shiina, E. Kikkawa, H. Inoko, and T. Awata Genomic structure around joining segments and constant regions of swine T-cell receptor α/δ (TRA/TRD) locus Immunology 109 2003 515 526
36. I. Villey, D. Caillol, F. Selz, P. Ferrier, and J.P. de Villartay Defect in rearrangement of the most 5′ TCR-Jα following targeted deletion of T early α (TEA): implications for TCR α locus accessibility Immunity 5 1996 331 342
37. F. Wang, C.Y. Huang, and O. Kanagawa Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation Proc. Natl. Acad. Sci. U.S.A. 95 1998 11834 11839
38. Watanabe, M., Iwasaki, Y., Mita, Y., Ota, S., Yamada, S., Shimizu, M., Takagaki, Y., submitted for publication. Porcine T-cell receptor β-chain: a genomic sequence covering Dβ1.1 to Cβ2 gene segments and the diversity of cDNA expressed in piglets including a novel alternative splicing product.
39. R.K. Wilson, B.F. Koop, C. Chen, N. Halloran, R. Sciammis, and L. Hood Nucleotide sequence analysis of 95 kb near the 3′ end of the murine T-cell receptor α/δ chain locus: strategy and methodology Genomics 13 1992 1198 1208
40. K. Yamada, D.H. Sachs, and H. DerSimonian Direct and indirect recognition of pig class II antigens by human T cells Transplant. Proc. 27 1995 258 259
41. Yamamoto, R., Uenishi, H., Hatsuse, H., Sato, E., Awata, T., Yasue, H., Takagaki, 2005. TRAV gene usage in porcine T cell receptor alpha cDNA. Immunogenetics, in press.
42. Y.G. Yang, S. Ohta, S. Yamada, M. Shimizu, and Y. Takagaki Diversity of T cell receptor δ-chain cDNA in the thymus of a one-month-old pig J. Immunol. 155 1995 1981 1993