Solution NMR spectroscopy of the human vasopressin V2 receptor, a G protein-coupled receptor

Journal of the American Chemical Society

Volumn 127, Issue 22, 2005, Pages 8010-8011

  Tian, Changlin ^a   Breyer, Richard M ^a   Kim, Hak Jun ^a   Karra, Murthy D ^a   Friedman, David B ^a   Karpay, Anne ^a   Sanders, Charles R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; VASOPRESSIN V2 RECEPTOR;

ARTICLE; DIABETES INSIPIDUS; ESCHERICHIA COLI; FLUID BALANCE; HUMAN; KIDNEY POLYCYSTIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PROTEIN STRUCTURE; TEMPERATURE;

ESCHERICHIA COLI; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, VASOPRESSIN; RECOMBINANT PROTEINS; SOLUTIONS;

EID: 20444392092     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja051161b     Document Type: Article

References (45)

1. Fredriksson, R.; Lagerstrom, M. C.; Lundin, L. G.; Schioth, H. B. Mol. Pharmacol. 2003, 63, 1256-1272.
2. Schoneberg, T.; Schulz, A.; Biebermann, H.; Hermsdorf, T.; Rompler, H.; Sangkuhl, K. Pharmacol. Ther. 2004, 104, 173-206.
3. Spiegel, A. M.; Weinstein, L. S. Annu. Rev. Med. 2004, 55, 27-39.
4. Hopkins, A. L.; Groom, C. R. Nat. Rev. Drug Discovery 2002, 1, 727-730.
5. Okada, T.; Fujiyoshi, Y.; Silow, M.; Navarro, J.; Landau, E. M.; Shichida, Y. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 5982-5987.
6. Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C. A.; Motoshima, H.; Fox, B. A.; Le, T. I.; Teller, D. C.; Okada, T.; Stenkamp, R. E.; Yamamoto, M.; Miyano, M. Science 2000, 289, 739-745.
7. (a) MacKenzie, K. R.; Prestegard, J. H.; Engelman, D. M. Science 1997, 276, 131-133.
8. (b) Girvin, M. E.; Rastogi, V. K.; Abildgaard, F.; Markley, J. L.; Fillingame, R. H. Biochemistry 1998, 37, 8817-8824.
9. (c) Arora, A.; Abildgaard, F.; Bushweller, J. H.; Tamm, L. K. Nat. Struct. Biol. 2001, 8, 334-338.
10. Fernandez, C.; Hilty, C.; Wider, G.; Guntert, P.; Wuthrich, K. J. Mol. Biol. 2004, 336, 1211-1221.
11. Hwang, P. M.; Bishop, R. E.; Kay, L. E. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 9618-9623.
12. (a) Howell, S. C.; Mesleh, M. F.; Opella S. J. Biochemistry 2005, 44, 5196-5206.
13. (b) Roosild, T. P.; Greenwald, J.; Vega, M.; Castronovo, S.; Riek, R.; Choe, S. Science 2005, 307, 1317-1321.
14. Albert, A. D.; Yeaele, P. L. Biochim. Biophys. Acta 2002, 1565, 183-195.
15. Demene, H.; Granier, S.; Muller, D.; Guillon, G.; Dufour, M. N.; Delsuc, M. A.; Hibert, M.; Pascal, R.; Mendre, C. Biochemistry 2003, 42, 8204-8213.
16. Mierke, D. F.; Giragossian, C. Med. Res. Rev. 2001, 21, 450-471.
17. Grace, C. R.; Perrin, M. H.; DiGruccio, M. R.; Miller, C. L.; Rivier, J. E.; Vale, W. W.; Riek, R. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 12836-12841.
18. Kisselev, O. G.; Kao, J.; Ponder, J. W.; Fann, Y. C.; Gautam, N.; Marshall, G. R. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 4270-4275.
19. Koenig, B. W.; Mitchell, D. C.; Konig, S.; Grzesiek, S.; Litman, B. J.; Bax, A. J. Biomol. NMR 2000, 16, 121-125.
20. Furukawa, H.; Hamada, T.; Hayashi, M. K.; Haga, T.; Muto, Y.; Hirota, H.; Yokoyama, S.; Nagasawa, K.; Ishiguro, M. Mol. Pharmacol. 2002, 62, 778-787.
21. Inooka, H.; Ohtaki, T.; Kitahara, O.; Ikegami, T.; Endo, S.; Kitada, C.; Ogi, K.; Onda, H.; Fujino, M.; Shirakawa, M. Nat. Struct. Biol. 2001, 8, 161-165.
22. Klein-Seetharaman, J.; Reeves, P. J.; Loewen, M. C.; Getmanova, E. V.; Chung, J.; Schwalbe, H.; Wright, P. E.; Khorana, H. G. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 3452-3457.
23. Klein-Seetharaman, J.; Yanamala, N. V.; Javeed, F.; Reeves, P. J.; Getmanova, E. V.; Loewen, M. C.; Schwalbe, H.; Khorana, H. G. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 3409-3413.
24. Loewen, M. C.; Klein-Seetharaman, J.; Getmanova, E. V.; Reeves, P. J.; Schwalbe, H.; Khorana, H. G. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 4888-4892.
25. As exemplified in ref 23, there is also a body of solution NMR data for the bacterial protein, bacteriorhodopsin (BR), a protein with some resemblance to GPCRs. However, the feasibility of solving its structure using solution NMR is unclear from the published data. We regret that space does not permit citation of several excellent solid-state NMR studies of specifically labeled receptor and/or associated ligands.
26. (a) Schubert, M.; Kolbe, M.; Kessler, B.; Oesterhelt, D.; Schmieder, P. Chembiochem 2002, 3, 1019-1023.
27. (b) Grabchuk, I. A.; Orekhov, V. Y.; Arseniev, A. S. Pharm. Acta Helv. 1996, 71, 97-102.
28. Birnbaumer, M. Recept. Channels 2002, 8, 51-56.
29. Thibonnier, M.; Coles, P.; Thibonnier, A.; Shoham, M. Prog. Brain Res. 2002, 139, 179-196.
30. Morello, J. P.; Bichet, D. G. Annu. Rev. Physiol. 2001, 63, 607-630.
31. Morello, J. P.; Petaja-Repo, U. E.; Bichet, D. G.; Bouvier, M. Trends Pharmacol. Sci. 2000, 21, 466-469.
32. Gattone, V. H.; Wang, X.; Harris, P. C.; Torres, V. E. Nat. Med. 2003, 9, 1323-1326.
33. Innamorati, G.; Sadeghi, H.; Birnbaumer, M. Mol. Pharmacol. 1996, 50, 467-473.
34. Sadeghi, H.; Birnbaumer, M. Glycobiology 1999, 9, 731-737.
35. Schulein, R.; Liebenhoff, U.; Muller, H.; Birnbaumer, M.; Rosenthal, W. Biochem. J. 1996, 313 (Pt 2), 611-616.
36. (a) Breyer, R. M.; Strosberg, A. D.; Guillet, J.-G. EMBO J. 1990, 9, 2679-2684.
37. (b) Furukawa, H.; Haga, T. J. Biochem. (Tokyo) 2000, 127, 151-161.
38. (c) White, J. F.; Trinh, L. B.; Shiloach, J.; Grisshammer, R. FEBS Lett. 2004, 564, 289-293.
39. (d) Baneres, J.-L.; Martin, A.; Hullot, P.; Girard, J.-P.; Rossi, J.-C.; Parello, J. J. Mol. Biol. 2003, 329, 801-814.
40. Riek, R.; Pervushin, K.; Wuthrich, K. Trends Biochem. Sci. 2000, 25, 462-468.
41. Detailed methods are provided in the Supporting Information.
42. (a) Aiyar, N.; Bennett, C. F.; Nambi, P.; Valinski, W.; Angioli, M.; Minnich, M.; Crooke, S. T. Biochem. J. 1989, 261, 63-70.
43. (b) Aiyar, N.; Valinski, W.; Nambi, P.; Minnich, M.; Stassen, F. L.; Crooke, S. T. Arch. Biochem. Biophys. 1989, 265, 698-706.
44. Krueger-Koplin, R. D.; Sorgen, P. L.; Krueger-Koplin, S. T.; Rivera-Torres, I. O.; Cahill, S. M.; Hicks, D. B.; Grinius, L.; Krulwich, T. A.; Girvin, M. E. J. Biomol. NMR 2004, 28, 43-57.
45. It is possible that some amide peaks from transmembrane segments could be missing in the spectra of V2R because of incomplete amide deuterium-to-hydrogen back exchange after biosynthetic perdeuteration.