Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow

Biochemical Pharmacology

Volumn 70, Issue 1, 2005, Pages 30-36

  Ulbrich, H ^a,d   Soehnlein, O ^a   Xie, X ^a   Eriksson, E E ^a   Lindbom, L ^a   Albrecht, W ^b   Laufer, S ^c   Dannhardt, G ^d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TEVA PHARMACEUTICALS   (Israel)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

5 Lipoxygenase; 5 LOX COX inhibition; Adhesion; Cyclooxygenase; Endothelium; Leukocyte; Rolling; Selectin

Indexed keywords

6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; CELECOXIB; CELL ADHESION MOLECULE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INDOMETACIN; INTERCELLULAR ADHESION MOLECULE 1; LICOFELONE; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; BIOACCUMULATION; BIOSYNTHESIS; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; ENDOTHELIUM; ENDOTHELIUM CELL; LEUKOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION;

ACETIC ACIDS; ARACHIDONATE 5-LIPOXYGENASE; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; ENDOTHELIAL CELLS; HUMANS; LEUKOCYTES; LIPOXYGENASE INHIBITORS; PYRROLES; RNA, MESSENGER;

EID: 20444374501     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.03.031     Document Type: Article

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