Indications of an altered immune balance in preeclampsia: A decrease in in vitro secretion of IL-5 and IL-10 from blood mononuclear cells and in blood basophil counts compared with normal pregnancy

Journal of Reproductive Immunology

Volumn 66, Issue 1, 2005, Pages 69-84

  Jonsson, Yvonne ^a   Matthiesen, Leif ^a   Berg, Göran ^a   Ernerudh, Jan ^a   Nieminen, Katri ^a   Ekerfelt, Christina ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cytokines; ELISA; In vitro; Preeclampsia; Th1 Th2

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 5; INTERLEUKIN 6; TETANUS TOXOID; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PURIFICATION; ARTICLE; BASOPHIL; CELL COUNT; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRANULOCYTE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; SUPERNATANT;

BASOPHILS; DOWN-REGULATION; FEMALE; HUMANS; HYPERSENSITIVITY; INTERLEUKIN-10; INTERLEUKIN-5; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; PRE-ECLAMPSIA; PREGNANCY; TH2 CELLS;

EID: 20444374109     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2005.02.002     Document Type: Article

References (42)

1. N. Anim-Nyame, J. Gamble, S.R. Sooranna, M.R. Johnson, and P.J. Steer Microvascular permeability is related to circulating levels of tumour necrosis factor-alpha in pre-eclampsia Cardiovasc. Res. 58 2003 162 169
2. A.E. Barden, L.J. Beilin, J. Ritchie, B.N. Walters, D. Graham, and C.A. Michael Is proteinuric pre-eclampsia a different disease in primigravida and multigravida? Clin. Sci. 97 1999 475 483
3. A. Benian, R. Madazli, F. Aksu, H. Uzun, and S. Aydin Plasma and placental levels of interleukin-10, transforming growth factor-beta1, and epithelial-cadherin in preeclampsia Obstet. Gynecol. 100 2002 327 331
4. L.C. Borish, and J.W. Steinke Cytokines and chemokines J. Allergy Clin. Immunol. 111 2003 S460 S475
5. A. Bøyum Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. Suppl. 97 1968 77 89
6. G. Chaouat, A.A. Meliani, J. Martal, R. Raghupathy, J. Elliot, T. Mosmann, and T. Wegmann IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-g J. Immunol. 154 1995 4261 4268
7. K.P. Conrad, T.M. Miles, and D.F. Benyo Circulating levels of immunoreactive cytokines in women with preeclampsia Am. J. Reprod. Immunol. 40 1998 102 111
8. J.H. Curfs, J.F. Meis, and J.A. Hoogkamp-Korstanje A primer on cytokines: sources, receptors, effects, and inducers Clin. Microbiol. Rev. 10 1997 742 780
9. D. Darmochwal-Kolarz, J. Rolinski, B. Leszczynska-Goarzelak, and J. Oleszczuk The expressions of intracellular cytokines in the lymphocytes of preeclamptic patients Am. J. Reprod. Immunol. 48 2002 381 386
10. G. Dekker, and P.Y. Robillard The birth interval hypothesis: does it really indicate the end of the primipaternity hypothesis J. Reprod. Immunol. 59 2003 245 251
11. G.A. Dekker, and B.M. Sibai Etiology and pathogenesis of preeclampsia: current concepts Am. J. Obstet. Gynecol. 179 1998 1359 1375
12. D.J. Dudley, C. Hunter, M.D. Mitchell, M.W. Varner, and M. Gately Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia and HELLP syndrome J. Reprod. Immunol. 31 1996 97 107
13. C. Ekerfelt, L. Matthiesen, G. Berg, and J. Ernerudh Paternal leukocytes selectively increase secretion of IL-4 in peripheral blood during normal pregnancies: demonstrated by a novel one-way MLC measuring cytokine secretion Am. J. Reprod. Immunol. 38 1997 320 326
14. E. Gratacos, X. Filella, M. Palacio, V. Cararach, P.L. Alonso, and A. Fortuny Interleukin-4, interleukin-10, and granulocyte-macrophage colony stimulating factor in second-trimester serum from women with preeclampsia Obstet. Gynecol. 92 1998 849 853
15. N. Hanna, I. Hanna, M. Hleb, E. Wagner, J. Dougherty, D. Balkundi, J.F. Padbury, and S. Sharma Gestational age-dependent expression of interleukin-10 and its receptor in human placental tissues and isolated cytotrophoblasts J. Immunol. 164 2000 5721 5728
16. M.C. Jenmalm, J. Van Snick, F. Cormont, and B. Salman Allergen-induced Th1 and Th2 cytokine secretion in relation to specific allergen sensitization and atopic symptoms in children Clin. Exp. Allergy 31 2001 1528 1535
17. Y. Jonsson, C. Ekerfelt, G. Berg, K. Nieminen, S. Sharma, J. Ernerudh, and L. Matthiesen Systemic Th1/Th2 cytokine responses to paternal and vaccination antigens in preeclampsia: no differences compared with normal pregnancy Am. J. Reprod. Immunol. 51 2004 302 310
18. S. Lurie, E. Frenkel, and Y. Tuvbin Comparison of the differential distribution of leukocytes in preeclampsia versus uncomplicated pregnancy Gynecol. Obstet. Invest. 45 1998 229 231
19. J.W. Meekins, P.J. McLaughlin, D.C. West, I.R. McFadyen, and P.M. Johnson Endothelial cell activation by tumour necrosis factor-alpha (TNF-alpha) and the development of pre-eclampsia Clin. Exp. Immunol. 98 1994 110 114
20. I. Munno, L.M. Chiechi, G. Lacedra, C. Berardesca, C. Patimo, L. Marcuccio, P. Nardelli, and P. Loizzi Evaluation of nonspecific immunity and plasma levels of interferon-gamma, interleukin-6 and tumor necrosis factor-alpha in preeclampsia Immunopharmacol. Immunotoxicol. 21 1999 551 564
21. J.A. Need Pre-eclampsia in pregnancies by different fathers Brit. Med. J. ii 1975 548 549
22. S. Orange, J. Horvath, and A. Hennessy Preeclampsia is associated with a reduced interleukin-10 production from peripheral blood mononuclear cells Hypertens. Pregnancy 22 2003 1 8
23. S.R. Paludan Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship Scand. J. Immunol. 48 1998 459 468
24. S. Quan, L.K. Poulsen, C.M. Reimert, C. Glue, A. Millner, B.M. Jensen, T. Jinquan, and P. Stahl Skov Spontaneous and cytokine induced basophil adhesion evaluated by microtiter assay J. Immunol. Meth. 262 2002 121 127
25. C.W.G. Redman, P.G. Sacks, and I.L. Sargent Preeclampsia: an excessive maternal inflammatory response to pregnancy Am. J. Obstet. Gynecol. 180 1999 499 506
26. D.T. Rein, M. Breidenbach, B. Honscheid, U. Friebe-Hoffmann, H. Engel, U.-J. Gohring, L. Uekermann, C.M. Kurbacher, and T. Schondorf Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro Cytokine 23 2003 119 125
27. J.M. Roberts, R.N. Taylor, T.J. Musci, G.M. Rodgers, C.A. Hubel, and M.K. McLaughlin Preeclampsia: an endothelial cell disorder Am. J. Obstet. Gynecol. 161 1989 1200 1204
28. S. Romagnani T-cell subsets (Th1 versus Th2) Ann. Allergy Asthma Immunol. 85 9-18 2000 quiz 18, 21
29. G. Sacks, I. Sargent, and C. Redman An innate view of human pregnancy Immunol. Today 20 1999 114 118
30. G.P. Sacks, D. Scott, H. Tivnann, T. Mire-Sluis, I.L. Sargent, and C.W. Redman Interleukin-12 and pre-eclampsia J. Reprod. Immunol. 34 1997 155 158
31. S. Saito, M. Sakai, Y. Sasaki, K. Tanabe, H. Tsuda, and T. Michimata Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia Clin. Exp. Immunol. 117 1999 550 555
32. S. Saito, H. Umekage, Y. Sakamoto, M. Sakai, K. Tanebe, Y. Sasaki, and H. Morikawa Increased T-Helper-1-type immunity and decreased T-Helper-2-type immunity in patients with preeclampsia Am. J. Reprod. Immunol. 41 1999 297 306
33. Y. Shimaoka, Y. Hidaka, H. Tada, T. Nakamura, N. Mitsuda, Y. Morimoto, Y. Murata, and N. Amino Changes in cytokine production during and after normal pregnancy Am. J. Reprod. Immunol. 44 2000 143 147
34. R. Skjaerven, A.J. Wilcox, and R.T. Lie The interval between pregnancies and the risk of preeclampsia N. Engl. J. Med. 346 2002 33 38
35. A. Taylor, J. Verhagen, C.A. Akdis, and M. Akdis T regulatory cells in allergy and health: a question of allergen specificity and balance Int. Arch. Allergy Immunol. 135 2004 73 82
36. G. Trinchieri Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes Blood 84 1994 4008 4027
37. L.I. Trogstad, A. Eskild, P. Magnus, S.O. Samuelsen, and B.I. Nesheim Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk: a study of 547 238 women with and without previous pre-eclampsia Int. J. Epidemiol. 30 2001 1317 1322
38. G.S. Vince, and P.M. Johnson Is there a Th2 bias in human pregnancy? J. Reprod. Immunol. 32 1996 101 104
39. G.S. Vince, P.M. Starkey, R. Austgulen, D. Kwiatkowski, and C.W. Redman Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia Br. J. Obstet. Gynaecol. 102 1995 20 25
40. T.G. Wegmann, H. Lin, L. Guilbert, and T.R. Mosmann Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol. Today 14 1993 353 356
41. J.R. Wilczynski, H. Tchorzewski, E. Glowacka, M. Banasik, P. Lewkowicz, M. Szpakowski, K. Zeman, and J. Wilczynski Cytokine secretion by decidual lymphocytes in transient hypertension of pregnancy and pre-eclampsia Mediators Inflamm. 11 2002 105 111
42. Working Group on High Blood Pressure in Pregnancy, 1990. National High Blood Pressure Education Program Working Group report on high blood pressure in pregnancy: Consensus report. Am. J. Obstet. Gynecol. 163, 1689-1712.