Systemic Th1/Th2 cytokine responses to paternal and vaccination antigens in preeclampsia: No differences compared with normal pregnancy

American Journal of Reproductive Immunology

Volumn 51, Issue 4, 2004, Pages 302-310

  Jonsson, Yvonne ^a   Ekerfelt, Christina ^a   Berg, Göran ^b   Nieminen, Katri ^b   Sharma, Surendra ^c   Ernerudh, Jan ^a   Matthiesen, Leif ^b  

^a Department of Pathology   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c BROWN UNIVERSITY   (United States)

Author keywords

ELISPOT; Interferon ; Interleukin 10; Interleukin 12; Interleukin 4; Preeclampsia

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; TETANUS TOXOID; TUBERCULIN;

ANTIGEN SPECIFICITY; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSIVE ELEMENT; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FETOPLACENTAL UNIT; FETUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERMETHOD COMPARISON; LEUKOCYTE CULTURE; MYCOBACTERIUM TUBERCULOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TH1 CELL; TH2 CELL; VACCINATION;

EID: 1842588975     PISSN: 10467408     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2004.00161.x     Document Type: Article

References (36)

1. Wegmann TG, Lin H, Guilbert L, Mosmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14:353-356.
2. Shimaoka Y, Hidaka Y, Tada H, Nakamura T, Mitsuda N, Morimoto Y, Murata Y, Amino N: Changes in cytokine production during and after normal pregnancy. Am J Reprod Immunol 2000; 44:143-147.
3. Vince GS, Johnson PM: Is there a Th2 bias in human pregnancy? J Reprod Immunol 1996; 32:101-104.
4. Saito S, Umekage H, Sakamoto Y, Sakai M, Tanebe K, Sasaki Y, Morikawa H: Increased T helper1-type immunity and decreased T helper2-type immunity in patients with preeclampsia. Am J Reprod Immunol 1999; 41:297-306.
5. Omu AE, Makhseed M, al-Qattan F: The comparative value of interleukin-4 in sera of women with preeclampsia and cord sera. Nutrition 1995; 11:688-691.
6. Sacks GP, Scott D, Tivnann H, Mire-Sluis T, Sargent IL, Redman CW: Interleukin-12 and pre-eclampsia. J Reprod Immunol 1997; 34:155-158.
7. Dudley DJ, Hunter C, Mitchell MD, Varner MW, Gately M: Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia and HELLP syndrome. J Reprod Immunol 1996; 31:97-107.
8. Sakai M, Tsuda H, Tanebe K, Sasaki Y, Saito S: Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients. Am J Reprod Immunol 2002; 47:91-97.
9. Ewen C, Baca-Estrada ME: Evaluation of interleukin-4 concentration by ELISA is influenced by the consumption of IL-4 by cultured cells. J Interferon Cytokine Res 2001; 21:39-43.
10. Bullens DM, Kasran A, Peng X, Lorre K, Ceuppens JL: Effects of anti-IL-4 receptor monoclonal antibody on in vitro T-cell cytokine levels: IL-4 production by T cells from non-atopic donors. Clin Exp Immunol 1998; 113:320-326.
11. Tanguay S, Killion JJ: Direct comparison of ELISPOT and ELISA-based assays for detection of individual cytokine-secreting cells. Lymphokine Cytokine Res 1994; 13:259-263.
12. Ekerfelt C, Matthiesen L, Berg G, Ernerudh J: Paternal leukocytes selectively increase secretion of IL-4 in peripheral blood during normal pregnancies: Demonstrated by a novel one-way MLC measuring cytokine secretion. Am J Reprod Immunol 1997; 38:320-326.
13. Paludan SR: Interleukin-4 and Tnterferon-gamma: the quintessence of a mutual antagonistic relationship. Scand J Immunol 1998; 48:459-468.
14. Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S: Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T-cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150:353-360.
15. Piccinni MP, Scaletti C, Maggi E, Romagnani S: Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy. J Neuroimmunol 2000; 109:30-33.
16. Hanna N, Hanna I, Hleb M, Wagner E, Dougherty J, Balkundi D, Padbury J, Sharma S: Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts. J Immunol 2000; 164:5721-5728.
17. Boyum A: Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl 1968; 97:77-89.
18. Czerkinsky CC, Tarkowski A, Nilsson LA, Ouchterlony O, Nygren H, Gretzer C: Reverse enzyme-linked immunospot assay (RELISPOT) for the detection of cells secreting immunoreactive substances. J Immunol Methods 1984; 72:489-496.
19. Ekerfelt C, Ernerudh J, Bunikis J, Vrethem M, Aagesen J, Roberg M, Bergstrom S, Forsberg P: Compartmentalization of antigen-specific cytokine responses to the central nervous system in CNS borreliosis: Secretion of IFN-gamma predominates over IL-4 secretion in response to outer surface proteins of Lyme disease Borrelia spirochetes. J Neuroimmunol 1997; 79:155-162.
20. Gratacos E, Filella X, Palacio M, Cararach V, Alonso PL, Fortuny A: Interleukin-4, interleukin-10, and granulocyte-macrophage colony stimulating factor in second-trimester serum from women with preeclampsia. Obstet Gynecol 1998; 92:849-853.
21. Ekerfelt C, Ernerudh J, Jenmalm MC: Detection of spontaneous and antigen-induced human interleukin-4 responses in vitro: Comparison of ELISPOT, a novel ELISA and real-time RT-PCR. J Immunol Methods 2002; 260:55-67.
22. Ekerfelt C, Lidstrom C, Matthiesen L, Berg G, Sharma S, Ernerudh J: Spontaneous secretion of interleukin-4, interleukin-10 and interferon-gamma by first trimester decidual mononuclear cells. Am J Reprod Immunol 2002; 47:159-166.
23. Redman C: The fetal allograft. Fetal Med Rev 1990; 2:21-43.
24. Matthiesen L, Ekerfelt C, Berg G, Ernerudh J: Increased numbers of circulating interferon-gamma- and interleukin-4-secreting cells during normal pregnancy. Am J Reprod Immunol 1998; 39:362-367.
25. Matthiesen L, Khademi M, Ekerfelt C, Berg G, Sharma S, Olsson T, Ernerudh J: In situ detection of both inflammatory and anti-inflammatory cytokines in resting peripheral blood mononuclear cells during pregnancy. J Reprod Immunol 2003; 58:49-59.
26. Svenvik M, EkerRelt C: Increased IFN-gamma: response to transplantation antigens measured by cytokine MLC: Indictions for a bi-phasic response pattern. Transpl Immunol 2003; 11:101-105.
27. Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM: Cure of murine leishmaniasis with anti-interleukin-4 monoclonal antibody. Evidence for a T-cell-dependent, interferon gamma-independent mechanism. J Exp Med 1990; 171:115-127.
28. Morris L, Troutt AB, McLeod KS, Kelso A, Handman E, Aebischer T: Interleukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis. Infect Immun 1993; 61:3459-3465.
29. Racke MK, Bonomo A, Scott DE, Cannella B, Levine A, Raine CS, Shevach EM, Rocken M: Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994; 180:1961-1966.
30. Del Prete GF, De Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, Ricci M, Romagnani S: Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991; 88:346-350.
31. + helper T cells from atopic subjects. Eur J Immunol 1992; 22:1615-1620.
32. Robinson DS, Kay AB: Role of Th1 and Th2 cells in human allergic disorders. Chem Immunol 1996; 63:187-203.
33. Redman CA, Sacks GP, Sargent IL: Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999; 180:499-506.
34. BErish L: IL-10: evolving concepts. J Allergy Clin Immunol 1998; 101:293-297.
35. Chaouat G, Assal Meliani A, Martal J, Raghupathy R, Elliot J, Mosmann T, Wegmann TG: IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol 1995; 154:4261-4268.
36. Benian A, Madazli R, Aksu F, Uzun H, Aydin S: Plasma and placental levels of interleukin-10, transforming growth factor-beta1, and epithelial-cadherin in preeclampsia. Obstet Gynecol 2002; 100:327-331.