Block of HERG Human K+ Channel and IKr of Guinea Pig Cardiomyocytes by Chlorpromazine

Journal of Cardiovascular Pharmacology

Volumn 43, Issue 5, 2004, Pages 706-714

  Lee, So Young ^a   Choi, Se Young ^b   Youm, Jae Boum ^c   Ho, Won Kyung ^d   Earm, Yung E ^d   Lee, Chin O ^a   Jo, Su Hyun ^a,c  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b School of Dentistry   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

Chlorpromazine; HERG channel; LQT; Rapidly activating delayed rectifier K+ current; Torsades de pointes; Voltage dependence

Indexed keywords

CHLORPROMAZINE; NEUROLEPTIC AGENT; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CULTURE MEDIUM; DEPOLARIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTRIC POTENTIAL; GENE EXPRESSION; GUINEA PIG; HEART MUSCLE CELL; IC 50; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; RAPIDLY ACTIVATING DELAYED RECTIFIER POTASSIUM CURRENT; SLOWLY ACTIVATING DELAYED RECTIFIER POTASSIUM CURRENT; SUDDEN DEATH; TORSADE DES POINTES; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANTIPSYCHOTIC AGENTS; CATION TRANSPORT PROTEINS; CHLORPROMAZINE; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GUINEA PIGS; MYOCYTES, CARDIAC; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; XENOPUS LAEVIS;

EID: 2042524358     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200405000-00014     Document Type: Article

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