Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men

Journal of Infectious Diseases

Volumn 181, Issue 3, 2000, Pages 872-880

  Lyles, Robert H ^a,e   Muñoz, Alvaro ^a   Yamashita, Traci E ^a   Bazmi, Holly ^b   Detels, Roger ^c   Rinaldo, Charles R ^b   Margolick, Joseph B ^a   Phair, John P ^d   Mellors, John W ^b,f  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e EMORY UNIVERSITY   (United States)

^f UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; COHORT ANALYSIS; DISEASE COURSE; HOMOSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROCONVERSION; VIREMIA;

EID: 0034030697     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315339     Document Type: Article

References (27)

1. + lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997;126:946-54.
2. 2. Anastos K, Kalish LA, Hessol N, et al. The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1 infected women: results of the women's interagency HIV study. AIDS 1999;13: 1717-26.
3. + cell count. JAMA 1998;279:35-40.
4. 4. O'Brien TR, Blattner WA, Waters D, et al. Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study. JAMA 1996;276:105-10.
5. 5. Henrard DR, Phillips JF, Muenz LR, et al. Natural history of HIV-1 cell-free viremia. JAMA 1995;274:554-8.
6. 6. Katzenstein TL, Pedersen C, Nielsen C, Lundgren JD, Jakobsen PH, Gerstoft J. Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996;10:167-73.
7. 7. Bruisten SM, Frissen PHJ, Van Swieten P, et al. Prospective longitudinal analysis of viral load and surrogate markers in relation to clinical progression in HIV type 1-infected persons. AIDS Res Hum Retroviruses 1997;13:327-35.
8. 8. Keet IPM, Janssen M, Veugelers PJ, et al. Longitudinal analysis of CD4 T cell counts, T cell reactivity, and human immunodeficiency virus type 1 RNA levels in persons remaining AIDS-free despite CD4 cell counts <200 for >5 years. J Infect Dis 1997;176:665-71.
9. 9. O'Brien TR, Rosenberg PS, Yellin F, Goedert JJ. Longitudinal HIV-1 RNA levels in a cohort of homosexual men. J Acquir Immune Defic Syndr Hum Retrovirol 1998;18:155-61.
10. 10. Schacker TW, Hughes JP, Shea T, Coombs RW, Corey L. Biological and virologic characteristics of primary HIV infection. Ann Intern Med 1998;128:613-20.
11. 11. Lyles CM, Dorucci M, Vlahov D, et al. Longitudinal HIV-1 viral load in the Italian seroconversion study: correlates and temporal trends of viral load. J Infect Dis 1999;180:1018-24.
12. 12. Kaslow RA, Ostrow DG, Detels R, Phair JP, Polk BF, Rinaldo CR Jr. The Multicenter AIDS Cohort Study: rationale, organization, and selected characteristics of the participants. Am J Epidemiol 1987;126:310-8.
13. 13. Jacobson LP, Kirby AJ, Polk S, et al. Changes in survival after acquired immunodeficiency syndrome (AIDS): 1984-1991. Am J Epidemiol 1993;138:952-64.
14. 14. Giorgi JV, Cheng HL, Margolick JB, et al. Quality control in the flow cytometric measurement of T-lymphocyte subsets: the Multicenter AIDS Cohort Study Experience. Clin Immunol Immunopathol 1990;55:173-86.
15. 15. Kirstein L, Mellors JW, Rinaldo CR, et al. Effects of anticoagulant, processing delay, and assay method (branched DNA versus reverse transcriptase PCR) on type 1 RNA levels in plasma. J Clin Microbiol 1999;37: 2428-33.
16. 16. Kleeberger CA, Lyles RH, Margolick JB, Rinaldo CR, Phair JP, Giorgi JV. Viability and recovery of peripheral blood mononuclear cells cryopreserved for up to 12 years in a multicenter study. Clin Diagn Lab Immunol 1999;6:14-9.
17. 17. Taylor JMG, Cumberland WG, Sy JP. A stochastic model for analysis of longitudinal AIDS data. J Am Stat Assoc 1994;89:727-36.
18. 18. Littell RC, Milliken GA, Stroup WW, Wolfinger RD. SAS system for mixed models. Cary, NC: SAS Institute, 1996.
19. 19. Kleinbaum DG, Kupper LL, Muller KE. Applied regression analysis and other multivariable methods. Boston: PWS Kent, 1988.
20. 20. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1992; 41(RR-17):1-19.
21. 21. Cox DR. Regression models and life-tables. J R Stat Soc 1972; 34:187-220.
22. 22. Sterling TR, Lyles CM, Vlahov D, Astemborski J, Margolick JB, Quinn TC. Sex differences in longitudinal human immunodeficiency virus type 1 RNA levels among seroconverters. J Infect Dis 1999;180:666-72.
23. + T cell numbers in progression of HIV type 1 infection. AIDS Res Hum Retroviruses 1998;14:1423-33.
24. 24. Detels R, Muñoz A, McFarlane G, et al. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. JAMA 1998;280:1497-503.
25. 25. Phair JP, Margolick JB, Jacobson LJ, et al. Detection of infection with human immunodeficiency virus type 1 before seroconversion: correlation with clinical symptoms and outcome. J Infect Dis 1997;175:959-62.
26. 26. de Jong MD, de Boer RJ, de Wolf F, et al. Overshoot of HIV-1 viraemia after early discontinuation of antiretroviral treatment: role of increased target cell availability? AIDS 1997;11:F79-84.
27. 27. de Boer RJ, Boucher CAB, Perelson AS. Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine. AIDS 1998;12:1567-70.