Imaging of myocardial metabolism

Journal of Nuclear Cardiology

Volumn 12, Issue 3, 2005, Pages 345-358

  Herrero, Pilar ^a   Gropler, Robert J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; FLUORODEOXYGLUCOSE F 18; HYDROGEN; IODINE 123; NITROGEN 15; OXYGEN 15; RADIOPHARMACEUTICAL AGENT; SODIUM 23;

AGING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONGESTIVE CARDIOMYOPATHY; DIABETES MELLITUS; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; ELECTROCARDIOGRAPHY; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART SCINTISCANNING; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INTERMETHOD COMPARISON; METHODOLOGY; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

CARDIOVASCULAR DISEASES; GENE EXPRESSION PROFILING; HEART; HUMANS; MAGNETIC RESONANCE IMAGING; MYOCARDIUM; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 20344408042     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nuclcard.2005.03.010     Document Type: Review

References (114)

1. R.J. Bing The metabolism of the heart Harvey Lect 50 1955 27-70
2. J.R. Neely H.E. Morgan Relationship between carbohydrate metabolism and energy balance of heart muscle Ann Rev Physiol 36 1974 413-459
3. B. Desvergne W. Wahli Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr Rev 20 1999 649-688
4. P.M. Barger D.P. Kelly PPAR signaling in the control of cardiac energy metabolism Trends Cardiovasc Med 10 2000 238-245
5. G.W. Goodwin C.S. Taylor H. Taegtmeyer Regulation of energy metabolism of the heart during acute increase in heart work J Biol Chem 273 1998 29530-29539
6. G.W. Goodwin F. Ahmad T. Doenst H. Taegtmeyer Energy provision from glycogen, glucose, and fatty acids on adrenergic stimulation of isolated working rat hearts Am J Physiol 274 Pt 2 1998 H1239-H1247
7. C. Depre J.J. Vanoverschelde H. Taegtmeyer Glucose for the heart Circulation 99 1999 578-588
8. W.C. Stanley G.D. Lopaschuck J.L. Hall J.G. McCormack Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions Cardiovasc Res 33 1997 243-257
9. H. Taegtmeyer A.F.C. Roberts A.E.G. Raine Energy metabolism in reperfused heart muscle J Am Coll Cardiol 6 1985 864-870
10. G.R. Heyndricks W. Wijns D. Vogelaers Y. Degrieck A. Bol G. Vandeplassche Recovery of regional contractile function and oxidative metabolism in stunned myocardium induced by 1-hour circumflex coronary artery stenosis in chronically instrumented dogs Circ Res 72 1993 901-913
11. D.W. Myears B.E. Sobel S.R. Bergmann Substrate use in ischemic and reperfused canine myocardium: Quantitative considerations Am J Physiol Heart Circ Physiol 253 1987 H107-H114
12. H. Taegtmeyer M.L. Overturf Effects of moderate hypertension on cardiac function and metabolism in the rabbit Hypertension 11 1988 416-426
13. M.N. Sack T.A. Rader S. Park J. Bastin S.A. McCune D.P. Kelly Mitochondrial fatty acid oxidation enzyme gene expression is downregulated in the failing heart Circulation 94 1996 2837-2842
14. B.R. Chaitman C.J. Pepine J.O. Parker J. Skopal G. Chumakova J. Kuch et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial JAMA 291 2004 309-316
15. E.D. Lewandowski Cardiac carbon 13 magnetic resonance spectroscopy: On the horizon or over the rainbow J Nucl Cardiol 9 2002 419-428
16. L.S. Szczepaniak E.E. Babcock F. Schick R.L. Dobbins A. Garg D.K. Burns et al. Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo Am J Physiol Endocrinol Metab 276 Pt 1 1999 E977-E989
17. 31P-MRS J Physiol Anthropol Appl Human Sci 21 2002 247-255
18. L. Luzi G. Perseghin G. Tambussi E. Meneghini P. Scifo E. Pagliato et al. Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy Am J Physiol Endocrinol Metab 284 2003 E274-E280
19. I.J. Cox Development and applications of in vivo clinical magnetic resonance spectroscopy Prog Biophys Mol Biol 65 1996 45-81
20. R.L. Dobbins C.R. Malloy Measuring in-vivo using nuclear magnetic resonance Curr Opin Clin Nutr Metab Care 6 2003 501-509
21. 13C glucose metabolism in conscious rats Am J Physiol Heart Circ Physiol 279 2000 H375-H381
22. M.R. Laughlin J.F. Taylor A.S. Chesnick R.S. Balaban Regulation of glycogen metabolism in canine myocardium: Effects of insulin and epinephrine in vivo Am J Physiol 262 1992 E875-E883
23. R. Deslauriers V.V. Kupriyanov Cardiac magnetic resonance spectroscopy Biochem Cell Biol 76 1998 510-521
24. G.M. Abu-Erreish J.R. Neely J.T. Whitmer V. Whitman D.R. Sanadi Fatty acid oxidation by isolated perfused working hearts of aged rats Am J Physiol 232 1977 E258-E262
25. J.B. McMillin G.E. Taffet H. Taegtmeyer E.K. Hudson C.A. Tate Mitochondrial metabolism and substrate competition in the aging Fischer rat heart Cardiovasc Res 27 1993 2222-2228
26. J.A. Odiet M. Boerrigter J.Y. Wei Carnitine palmitoyl transferase-I activity in the aging mouse heart Mech Ageing Dev 79 1995 127-136
27. M. Iemitsu T. Miyauchi S. Maeda T. Tanabe M. Takanashi Y. Irukayama-Tomobe et al. Age-induced decrease in the PPAR-α level in hearts improved by exercise training Am J Physiol Heart Circ 283 2002 H1750-H1760
28. A.M. Kates P. Herrero C. Dence P. Soto M. Srinivasan D.G. Delano et al. Impact of aging on substrate metabolism by the human heart J Am Coll Cardiol 41 2003 293-299
29. P. Soto P. Herrero R. Kowalski J. Beereport A. Ehsani V. Davila-Roman et al. Impact of aging on dobutamine-induced changes in myocardial substrate utilization Am J Physiol 285 2003 H2158-H2164
30. C.R. Roe P.M. Coates Mitochondrial fatty acid oxidation disorders In: C.R. Scriver A.I. Beaudet W.S. Sly D. Valle, editors The metabolic and molecular bases of inherited disease 1995 McGraw-Hill New York 1501-1533
31. E. Blair C. Redwood H. Ashrafian M. Oliveira J. Broxholme B. Kerr et al. Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis Hum Mol Genet 10 2001 1215-1220
32. H. Rupp R. Jacob Metabolically-modulated growth and phenotype of the rat heart Eur Heart J 13 1992 56-61
33. P.M. Barger D.P. Kelly PPAR signaling in the control of cardiac energy metabolism Trends Cardiovasc Med 10 2000 238-245
34. P.M. Barger D.P. Kelly Fatty acid utilization in the hypertrophied and failing heart: Molecular regulatory mechanisms Am J Med Sci 318 1999 36-42
35. Y. Jamshidi H.E. Montgomery H.W. Hense S.G. Myerson I.P. Torra B. Staels et al. Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension Circulation 105 2002 950-955
36. T. Mochizuki E. Tsukamoto T. Ono K. Itoh K. Kanaegae C. Katoh et al. Sequential changes in BMIPP uptake in perfused rate hearts Ann Nucl Med 11 1997 299-306
37. T. Ono T. Kohya E. Tsukamoto T. Mochizuki K. Itoh F. Tomita et al. Improved fatty acid utilization in relation to change in left ventricular hypertrophy in spontaneously hypertensive rats Jpn Circ J 64 2000 117-120
38. L. De las Fuentes P. Herrero L.R. Peterson D.P. Kelly R.J. Gropler V.G. Davila-Roman Myocardial fatty acid metabolism: Independent predictor of left ventricular mass in hypertension and in left ventricular dysfunction Hypertension 41 2003 82-87
39. B.M. Massie S. Schaefer J. Garcia M.D. McKirnan G.G. Schwartz J.A. Wisneski et al. Myocardial high-energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy Circulation 91 1995 1814-1823
40. R. Liao L. Nascimben J. Friedrich J.K. Gwathmey J.S. Ingwall Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance Circ Res 78 1996 893-902
41. S. Neubauer M. Horn M. Cramer K. Harre J.B. Newell W. Peters et al. Myocardial phosphocreatinine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy Circulation 96 1997 2190-2196
42. Z. El Alaoui-Talibi A. Landormy A. Loireau J. Morovec Fatty acid oxidation and mechanical performance of volume overloaded rat hearts Am J Physiol 262 1922 H1068-H1074
43. M.F. Allard B.O. Schonekess S.L. Henning D.R. English G.D. Lopaschuk Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts Am J Physiol 267 1994 H742-H750
44. B. Wittels J.F. Spann Jr Defective lipid metabolism in the failing heart J Clin Invest 47 1968 1787-1794
45. P.F. Kantor M.A. Robertson J.Y. Coe G.D. Lopaschuk Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism J Am Coll Cardiol 33 1999 1724-1734
46. A.M. Lompre K. Schwartz A. d'Albis G. Lacombe N. Van Thiem B. Swynghedauw Myosin isozymes redistribution in chronic heart overloading Nature 282 1979 105-107
47. P.M. Buttrick M. Kaplan L.A. Leinwand J. Scheuer Alterations in gene expression in the rat heart after chronic pathological and physiological loads J Mol Cell Cardiol 26 1994 61-67
48. H.C. Chiu A. Kovacs D.A. Ford F.F. Hsu R. Garcia P. Herrero et al. A novel mouse model of lipotoxic cardiomyopathy J Clin Invest 107 2001 813-822
49. L.A. Nikolaidis D. Elahi T. Hentosz A. Doverspike R. Huerbin L. Zourelias et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy Circulation 110 2004 955-961
50. 2+ cycling in isolated failing human myocardium Circulation 105 2002 194-199
51. C.B. Higgins M. Saeed M. Wendland W.M. Chew Magnetic resonance spectroscopy of the heart. Overview of studies in animals and man Invest Radiol 24 1989 962-968
52. S. Neubauer High-energy phosphate metabolism in normal, hypertrophied and failing human myocardium Heart Fail Rev 4 1999 269-280
53. R.A. Goldstein M.S. Klein M.J. Welch B.E. Sobel External assessment of myocardial metabolism with C-11 palmitate in vivo J Nucl Med 21 1980 342-348
54. J.D. Eisenberg B.E. Sobel E.M. Geltman Differentiation of ischemic from nonischemic cardiomyopathy with positron emission tomography Am J Cardiol 59 1987 1410-1414
55. D.P. Kelly N.J. Mendelsohn B.E. Sobel S.R. Bergmann Detection and assessment by positron emission tomography of a genetically determined defect in myocardial fatty acid utilization (long-chain Acyl-CoA dehydrogenase deficiency) Am J Cardiol 71 1993 738-744
56. 123I BMIPP SPECT: Correlation with clinicopathological findings and clinical course Heart 81 1999 153-159
57. 18F]FDG in patients with congestive heart failure J Nucl Med 42 2001 55-62
58. T.R. Wallhaus M. Taylor T.R. DeGrado D.C. Russell P. Stanko R.J. Nickles et al. Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure Circulation 103 2001 2441-2446
59. V.G. Davila-Roman G. Vedala P. Herrero L. de las Fuentes J.G. Rogers D.P. Kelly et al. Altered fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy J Am Coll Cardiol 40 2002 271-277
60. 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure Circulation 86 1992 1810-1818
61. 31P-magnetic resonance spectroscopy to the understanding of dilated heart muscle disease Eur Heart J 16 Suppl O 1995 115-118
62. R.S. Beanlands W.F. Armstrong R.J. Hicks J. Nicklas C. Moore G.D. Hutchins et al. The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy J Nucl Cardiol 1 1994 3-16
63. K.Q. Stolen J. Kemppainen H. Ukkonen K.K. Kalliokoski M. Luotolahti P. Lehikoinen et al. Exercise training improves biventricular oxidative metabolism and left ventricular efficiency in patients with dilated cardiomyopathy J Am Coll Cardiol 41 2003 460-467
64. J. Sundell E. Engblom J. Koistinen A. Ylitalo A. Naum K.Q. Stolen et al. The effects of cardiac resynchronization therapy on left ventricular function, myocardial energetics, and metabolic reserve in patients with dilated cardiomyopathy and heart failure J Am Coll Cardiol 43 2004 1027-1033
65. B. Nowak A.M. Sinha W.M. Schaefer K.C. Koch H.J. Kaiser P. Hanrath et al. Cardiac resynchronization therapy homogenizes myocardial glucose metabolism and perfusion in dilated cardiomyopathy and left bundle branch block J Am Coll Cardiol 41 2003 1523-1528
66. 1-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study Circulation 102 2000 2070-2075
67. S. Hasegawa H. Kusuoka K. Maruyama T. Nishimura M. Hori J. Hatazawa Myocardial positron emission computed tomographic images obtained with fluorine-18 fluoro-2-deoxyglucose predict the response of idiopathic dilated cardiomyopathy patients to beta-blockers J Am Coll Cardiol 43 2004 224-233
68. W.B. Kannel D.L. McGee Diabetes and cardiovascular disease: The Framingham study JAMA 241 1979 2035-2038
69. P. Koskinen M. Manttari V. Manninen J.K. Huttunen O.P. Heinonen M.H. Frick Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study Diabetes Care 15 1992 820-825
70. R.D. Abbott R.P. Donahue W.B. Kannel P.W. Wilson The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study JAMA 260 1988 3456-3460
71. W.B. Kannel M. Hjortland W.P. Castelli Role of diabetes in congestive heart failure the Framingham Study Am J Cardiol 34 1974 29-34
72. T.J. Regan M.M. Lyons S.S. Ahmed G.E. Levinson H.A. Oldewurtel M.R. Ahmed et al. Evidence for cardiomyopathy in familial diabetes mellitus J Clin Invest 60 1977 885-899
73. P.J. Palumbo C.R. Elveback D.C. Conolly Coronary artery disease and congestive heart failure in the diabetic: Epidemiological aspects. The Rochester Diabetes Project In: R.C. Scott, editor Clinical cardiology and diabetes 1981 Futura New York 13
74. J. Stamler O. Vaccaro J.D. Neaton D. Wentworth Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial Diabetes Care 16 1993 434-444
75. B.E. Sobel Fibrinolysis and diabetes Front Biosci 8 2003 1085-1092
76. A. Nitenberg P. Valensi R. Sachs M. Dali E. Aptecar J.R. Attali Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function Diabetes 42 1993 1017-1025
77. L. Poston P.D. Taylor Endothelium-mediated vascular function in insulin-dependent diabetes mellitus Clin Sci 88 1995 245-255
78. J. Gerritsen J.M. Dekker B.J. TenVoorde P.J. Kostense R.J. Heine L.M. Bouter et al. Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: The Hoorn Study Diabetes Care 24 2001 1793-1798
79. S. Rubler J. Dlugash Y.Z. Yuceoglu T. Kumral A.W. Branwood A. Grishman New type of cardiomyopathy associated with diabetic glomerulosclerosis Am J Cardiol 30 1972 595-602
80. W.C. Stanley G.D. Lopaschuck J.G. McCormack Regulation of energy substrate metabolism in the diabetic heart Cardiovasc Res 34 1997 25-33
81. B. Rodrigues M.C. Cam J.H. McNeill Myocardial substrate metabolism: implications for diabetic cardiomyopathy J Mol Cell Cardiol 27 1995 169-179
82. A. Avogaro R. Nosadini A. Doria P. Fioretto M. Velussi C. Vigorito et al. Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease Am J Physiol 258 1990 E606-E618
83. P.J. Randle D.A. Priestman S. Mistry A. Halsall Mechanisms modifying glucose oxidation in diabetes mellitus Diabetologia 37 1994 S155-S161
84. A.L. Kerbey T.C. Vary P.J. Randle Molecular mechanisms regulating myocardial glucose oxidation Basic Res Cardiol 80 1985 93-96
85. B. Huisamen M. van Zyl A. Keyser A. Lochner The effects of insulin and beta-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats Mol Cell Biochem 223 2001 15-25
86. P. Razeghi M.E. Young T.C. Cockrill O.H. Frazier H. Taegtmeyer Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure Circulation 106 2002 407-411
87. I. Ungar M. Gilbert A. Siegel J.M. Blain R.J. Bing Studies on myocardial metabolism. IV. Myocardial metabolism in diabetes Am J Med 18 1955 385-396
88. P. Randle P. Sugden A. Kerbey P.M. Radcliffe N.J. Hutson Regulation of pyruvate oxidation and the conservation of glucose Biochem Soc Symp 43 1978 47-67
89. P. Wu K. Inskeep M. Bowker-Kinley K.M. Popov R.A. Harris Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes Diabetes 48 1999 1593-1599
90. V. Chen C.D. Ianuzzo B.C. Fong J.J. Spitzer The effects of acute and chronic diabetes on myocardial metabolism in rats Diabetes 33 1984 1078-1084
91. D. Stroedter T. Schmidt R.G. Bretzel K. Federlin Glucose metabolism and left ventricular dysfunction are normalized by insulin and islet transplantation in mild diabetes in the rat Acta Diabetol 32 1995 235-243
92. M. Giffin G. Arthur P.C. Choy R.Y.K. Man Lysophosphatidyl choline metabolism and cardiac arrhythmias Can J Physiol 66 1988 185-189
93. G.C. Sparagna D.L. Hickson-Bick Cardiac fatty acid metabolism and the induction of apoptosis Am J Med Sci 318 1999 15-23
94. S.F. Vatner L. Hittinger Coronary vascular mechanisms involved in decompensation from hypertrophy to heart failure J Am Coll Cardiol 22 1993 34A-40A
95. B.N. Finck J.J. Lehman T.C. Leone M.J. Welch M.J. Bennett A. Kovacs et al. The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus J Clin Invest 109 2002 121-130
96. B.N. Finck X. Han M. Courtois F. Aimond J.M. Nerbonne A. Kovacs et al. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content Proc Natl Acad Sci U S A 100 2003 1226-1231
97. J.L. Hall W.C. Stanley G.D. Lopaschuk J.A. Wisneski R.D. Pizzuro C.D. Hamilton et al. Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work Am J Physiol 271 1996 H2320-H2329
98. A. Doria R. Nosadini A. Avogaro P. Fioretto G. Crepaldi Myocardial metabolism in type 1 diabetic patients without coronary artery disease Diabet Med 8 1991 S104-S107
99. 123I-heptadecanoic acid in subjects with impaired glucose tolerance Diabetologia 40 1997 541-549
100. J. Knuuti T.O. Takala K. Nagren H. Sipila A.K. Turpeinen M.I. Uusitupa et al. Myocardial fatty acid oxidation in patients with impaired glucose tolerance Diabetologia 44 2001 184-187
101. S. Neubauer C. Clarke Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes Circulation 107 2003 3040-3046
102. M. Diamant H. Lamb Y. Groeneveld E.L. Endert J.W.A. Smit J.J. Bax et al. Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus J Am Coll Cardiol 42 2003 328-335
103. K. Hallsten K.A. Virtanen F. Lonnqvist T. Janatuinen M. Turiceanu T. Ronnemaa et al. Enhancement of insulin-stimulated myocardial glucose uptake in patients with type 2 diabetes treated with rosiglitazone Diabet Med 21 2004 1280-1287
104. Y.T. Zhou P. Grayburn A. Karim M. Shimabukuro M. Higa D. Baetens et al. Lipotoxic heart disease in obese rats: Implications for human obesity Proc Natl Acad Sci U S A 97 2000 1784-1789
105. P.D. Berk S.L. Zhou C.L. Kiang D. Stump M. Bradbury L.M. Isola Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus J Biol Chem 272 1997 8830-8835
106. J.J. Luiken Y. Arumugam D.J. Dyck R.C. Bell M.M. Pelsers L.P. Turcotte et al. Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats J Biol Chem 276 2001 40567-40573
107. S.R. Commerford M.J. Pagliassotti C.L. Melby Y. Wei E.C. Gayles J.O. Hill Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats Am J Physiol Endocrinol Metab 279 2000 E875-E885
108. J.C. Blachere F. Perusse L.J. Bukowiecki Lowering plasma free fatty acids with Acipimox mimics the antidiabetic effects of the beta 3-adrenergic agonist CL-316243 in obese Zucker diabetic fatty rats Metabolism 50 2001 945-951
109. Y. Lee M.Y. Wang T. Kakuma Z.W. Wang E. Babcock K. McCorkle et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia J Biol Chem 276 2001 5629-5635
110. Z.W. Wang W.T. Pan Y. Lee T. Kakuma Y.T. Zhou R.H. Unger The role of leptin resistance in the lipid abnormalities of aging FASEB J 15 2001 108-114
111. D. Dyntar M. Eppenberger-Eberhardt K. Maedler M. Pruschy H.M. Eppenberger G.A. Spinas et al. Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes Diabetes 50 2001 2105-2113
112. L.L. Listenberger D.S. Ory J.E. Schaffer Palmitate-induced apoptosis can occur through a ceramide-independent pathway J Biol Chem 276 2001 14890-14895
113. L.R. Peterson P. Herrero K.B. Schechtman S.B. Racette A.D. Waggoner Z. Kisrieva-Ware et al. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women Circulation 109 2004 2191-2196
114. L.S. Szczepaniak R.L. Dobbins G.J. Metzger G. Sartoni-D'Ambrosia D. Arbique W. Vongpatanasin et al. Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging Magn Reson Med 49 2003 417-423