Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo

Molecular Microbiology

Volumn 56, Issue 6, 2005, Pages 1416-1429

  Pohlhaus, Jennifer Reineke ^a   Kreuzer, Kenneth N ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; NORFLOXACIN; PLASMID DNA; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RESTRICTION ENDONUCLEASE;

AGAR GEL ELECTROPHORESIS; ARTICLE; COVALENT BOND; CYTOTOXICITY; DNA CLEAVAGE; DNA ISOLATION; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG MECHANISM; ENZYME ACTIVE SITE; ESCHERICHIA COLI; HOLLIDAY JUNCTION; NONHUMAN; PRIORITY JOURNAL; SOUTHERN BLOTTING;

ANTI-INFECTIVE AGENTS; BINDING SITES; DNA; DNA DAMAGE; DNA GYRASE; DNA REPLICATION; DNA, BACTERIAL; ESCHERICHIA COLI; NORFLOXACIN; NUCLEIC ACID CONFORMATION; PLASMIDS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 20344370231     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04638.x     Document Type: Article

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