Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2265-2269

  Tatsuta, Miyuki ^a   Kataoka, Mikayo ^a   Yasoshima, Kayo ^a   Sakakibara, Sachiko ^a   Shogase, Yuka ^a   Shimazaki, Makoto ^a   Yura, Takeshi ^a   Li, Yingfu ^a   Yamamoto, Noriyuki ^a   Gupta, Jang ^a   Urbahns, Klaus ^a  

^a BAYER YAKUHIN LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; GONADORELIN ANTAGONIST;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

EID: 20244364839     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.030     Document Type: Article

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9. 1H NMR (500 MHz, DMSO-d6) δ 0.74 (3H, t, J = 7.3 Hz), 1.30 (9H, s), 1.46 (2H, sextet, J = 7.3 Hz), 1.79 (2H, quintet, J = 6.9 Hz), 1.90 (2H, quintet, J = 6.9 Hz), 3.16 (2H, t, J = 6.9 Hz), 3.51 (2H, t, J = 6.9 Hz), 3.92 (2H, t, J = 7.3 Hz), 3.97 (3H, s), 4.60 (2H, s), 5.94 (1H, s), 7.25 (1H, d, J = 9.1 Hz), 7.25 (1H, d, J = 1.9 Hz), 7.51 (1H, d, J = 1.9 Hz), 8.20 (1H, dd, J = 2.8, 9.1 Hz), 8.26 (1H, s), 8.40 (1H, d, J = 2.8 Hz)
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14. 1H NMR (500 MHz, DMSO-d6) δ 0.78 (3H, t, J = 7.3 Hz), 1.3 (9H, s), 1.65 (2H, sextet, J = 7.3 Hz), 3.97 (3H, s), 3.99 (2H, t, J = 7.3 Hz), 4.58 (2H, s), 5.88 (1H, s), 7.10 (1H, dd, J = 1.6, 8.5 Hz), 7.24 (1H, d, J = 9.2 Hz), 7.31 (1H, d, J = 8.5 Hz), 7.63 (1H, d, J = 1.6 Hz), 8.15 (1H, s), 8.19 (1H, dd, J = 2.8, 9.2 Hz), 8.38 (1H, d, J = 2.8 Hz)