Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 2: Benzimidazole-5-sulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 3, 2005, Pages 805-807

  Li, Yingfu ^a   Kataoka, Mikayo ^a   Tatsuta, Miyuki ^a   Yasoshima, Kayo ^a   Yura, Takeshi ^a   Urbahns, Klaus ^a   Kiba, Atsushi ^a   Yamamoto, Noriyuki ^a   Gupta, Jang B ^a   Hashimoto, Kentaro ^a,b  

^a BAYER YAKUHIN LTD   (Japan)

^b BAYER PHARMA AG   (Germany)

Author keywords

LHRH antagonist; Small molecule

Indexed keywords

BENZIMIDAZOLE; GONADORELIN; NANOPARTICLE; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BENZIMIDAZOLES; GONADOTROPIN-RELEASING HORMONE; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; UREA;

EID: 19944433139     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.090     Document Type: Article

References (4)

1. M.T. Goulet J.A. Bristol Annual Reports in Medicinal Chemisty Vol. 30 1995 Academic New York 169 178
2. Hashimoto, K.; Tatsuta, M.; Kataoka, M.; Yasoshima, K.; Shogase, Y.; Shimazaki, M.; Yura, T.; Li, Y.; Yamamoto, N.; Gupta, J. B.; Urbahns, K. Bioorg. Med. Chem. Lett. submitted for publication
3. 6) δ 1.19 (9H, s), 2.95-2.98 (2H, t, J = 6.6 Hz), 3.44-3.47 (2H, t, J = 6.9 Hz), 3.93-3.94 (1H, d, J = 6.0 Hz), 5.56 (2H, s), 5.79 (1H, s), 5.83-5.85 (1H, t, J = 6.0 Hz), 7.04-7.07 (2H, t, J = 9.14 Hz), 7.11-7.13 (2H, d, J = 6.9 Hz), 7.24-7.35 (5H, m), 7.61-7.67 (2H, dd, J = 8.5 Hz, 21 Hz), 8.03-8.05 (2H, m)
4. S. Sasaki, N. Cho, Y. Nara, M. Harada, S. Endo, N. Suzuki, S. Furuya, and M. Fujino J. Med. Chem. 46 2003 113