Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model

Circulation

Volumn 111, Issue 13, 2005, Pages 1672-1678

  Li, Yan ^a,c   Minamino, Tetsuo ^a   Tsukamoto, Osamu ^a   Yujiri, Toshiaki ^d   Shintani, Yasunori ^a   Okada, Ken Ichiro ^a   Nagamachi, Yoko ^a   Fujita, Masashi ^a   Hirata, Akio ^a   Sanada, Shoji ^a   Asanuma, Hiroshi ^a   Takashima, Seiji ^a   Hori, Masatsugu ^a   Johnson, Gary L ^e   Kitakaze, Masafumi ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Muscle, smooth; Remodeling; Restenosis; Vasculature

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; UROKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTERY LIGATION; ARTERY WALL; ARTICLE; BLOOD FLOW; CELL MIGRATION; CELL PROLIFERATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEGRADATION; ENZYME INHIBITION; MIGRATION INHIBITION; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; STRAIN DIFFERENCE; WILD TYPE; WOUND HEALING;

ANIMALS; AORTA; CAROTID STENOSIS; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPERPLASIA; MAP KINASE KINASE KINASE 1; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; TUNICA INTIMA; URINARY PLASMINOGEN ACTIVATOR;

EID: 20244363795     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000160350.20810.0F     Document Type: Article

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