Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator

Circulation

Volumn 106, Issue 14, 2002, Pages 1847-1852

  Schäfer, Katrin ^a   Konstantinides, Stavros ^a   Riedel, Carsten ^a   Thinnes, Therese ^b   Müller, Katja ^a   Dellas, Claudia ^a   Hasenfuss, Gerd ^a   Loskutoff, David J ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Atherosclerosis; Carotid arteries; Genes; Plasminogen activators; Thrombosis

Indexed keywords

FERRIC CHLORIDE; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; CAROTID ARTERY INJURY; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; GRAFT PATENCY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTIMA; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECANALIZATION; TUNICA MEDIA; WOUND HEALING;

ANIMALS; CAROTID ARTERIES; CAROTID STENOSIS; CELL COUNT; DISEASE MODELS, ANIMAL; FERRIC COMPOUNDS; HEMODYNAMIC PROCESSES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE PLASMINOGEN ACTIVATOR; TUNICA INTIMA; TUNICA MEDIA; URINARY PLASMINOGEN ACTIVATOR; VASCULAR PATENCY; WOUND HEALING;

EID: 0036787542     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000031162.80988.2B     Document Type: Article

References (23)

1. Collen D, Lijnen HR. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood. 1991;78:3114-3124.
2. Carmeliet P, Moons L, Herbert JM, et al. Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ Res. 1997;81:829-839.
3. Carmeliet P, Moons L, Stassen JM, et al. Vascular wound healing and neointima formation induced by perivascular electric injury in mice. Am J Pathol. 1997;150:761-776.
4. Matsuno H, Kozawa O, Niwa M, et al. Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury. Thromb Haemost. 1999;81:601-604.
5. Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275.
6. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001;104:365-372.
7. Konstantinides S, Schafer K, Thinnes T, et al. Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice. Circulation. 2001;103:576-583.
8. Konstantinides S, Schafer K, Koschnick S, et al. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest. 2001;108:1533-1540.
9. Zhu B, Kuhel DG, Witte DP, et al. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice. Am J Pathol. 2000;157:1839-1848.
10. van Aken BE, Seiffert D, Thinnes T, et al. Localization of vitronectin in the normal and atherosclerotic human vessel wall. Histochem Cell Biol. 1997;107:313-320.
11. Yamamoto K, Loskutoff DJ. Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator. J Clin Invest. 1996;97:2440-2451.
12. Carmeliet P, Schoonjans L, Kieckens L, et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994;368:419-424.
13. Phipps RP. Atherosclerosis: the emerging role of inflammation and the CD40-CD40 ligand system. Proc Natl Acad Sci USA. 2000;97:6930-6932.
14. Carmeliet P, Moons L, Dewerchin M. et al. Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice. J Cell Biol. 1998;140:233-245.
15. Lijnen HR, Van Hoef B, Lupu F, et al. Function of the plasminogen/ plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes. Arterioscler Thromb Vasc Biol. 1998;18:1035-1045.
16. Deng G, Curriden SA, Wang S, et al. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J Cell Biol. 1996;134:1563-1571.
17. Stefansson S, Lawrence DA. The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature. 1996;383:441-443.
18. Farrehi PM, Ozaki CK, Carmeliet P, et al. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation. 1998;97:1002-1008.
19. Kikuchi S, Umemura K, Kondo K, et al. Photochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimal thickening. Arterioscler Thromb Vasc Biol. 1998;18:1069-1078.
20. Ploplis VA, Cornelissen I, Sandoval-Cooper MJ, et al. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. Am J Pathol. 2001:158:107-117.
21. Glass CK, Witztum JL. Atherosclerosis: the road ahead. Cell. 2001;104:503-516.
22. Der Thusen JH, van Berkel TJ, Biessen EA. Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low density lipoprotein receptor-deficient mice. Circulation. 2001;103:1164-1170.
23. Zhu Y, Farrehi PM, Fay WP. Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice. Circulation. 2001;103:3105-3110.