Tetraspanins and intercellular interactions

Microcirculation

Volumn 8, Issue 3, 2001, Pages 153-168

  Yáñez Mó, María ^a   Mittelbrunn, María ^a   Sánchez Madrid, Francisco ^a  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Adhesion; Intercellular; Tetraspanin

Indexed keywords

MEMBRANE PROTEIN; METALLOPROTEINASE;

ANGIOGENESIS; ANIMAL; CELL ADHESION; CELL FUSION; CELL JUNCTION; CELL MOTION; GROWTH, DEVELOPMENT AND AGING; HEMATOPOIESIS; HUMAN; LYMPHOCYTE ACTIVATION; METASTASIS; NEOPLASM; NERVOUS SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM;

ANIMALS; CELL ADHESION; CELL FUSION; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; HEMATOPOIESIS; HUMANS; INTERCELLULAR JUNCTIONS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVOUS SYSTEM;

EID: 0035376066     PISSN: 10739688     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mn.7800076     Document Type: Article

References (197)

1. Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ. (1997). Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization. J Cell Biol 139:563-571.
2. Almeida EA, Huovila AP, Sutherland AE, Stephens LE, Calarco PG, Shaw LM, Mercurio AM, Sonnenberg A, Primakoff P, Myles DG. (1995). Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell 81:1095-1104.
3. Altomonte M, Montagner R, Pucillo C, Maio M. (1996). Triggering of target of an antiproliferative antibody-1 (TAPA-1/CD81) upregulates the release of tumour necrosis factor-alpha by the EBV-B lymphoblastoid cell line JY. Scand J Immunol 43:367-373.
4. Anton ES, Hadjiargyrou M, Patterson PH, Matthew WD. (1995). CD9 plays a role in Schwann cell migration in vitro. J Neurosci 15:584-595.
5. Anton ES, Kreidberg JA, Rakic P. (1999). Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron 22:277-289.
6. Aoyama K, Oritani K, Yokota T, Ishikawa J, Nishiura T, Miyake K, Kanakura Y, Tomiyama Y, Kincade PW, Matsuzawa Y. (1999). Stromal cell CD9 regulates differentiation of hematopoietic stem/ progenitor cells. Blood 93:2586-2594.
7. Banerjee SA, Hadjiargyrou M, Patterson PH. (1997). An antibody to the tetraspan membrane protein CD9 promotes neurite formation in a partially alpha3beta1 integrin-dependent manner. J Neurosci 17:2756-2765.
8. Banerjee SA, Patterson PH. (1995). Schwann cell CD9 expression is regulated by axons. Mol Cell Neurosci 6:462-473.
9. Bartolazzi A, Cerboni C, Nicotra MR, Mottolese M, Bigotti A, Natali PG. (1994). Transformation and tumor progression are frequently associated with expression of the alpha 3/beta 1 heterodimer in solid tumors, Int J Cancer 58:488-491.
10. Baudoux B, Castanares-Zapatero D, Leclercq-Smekens M, Berna N, Poumay Y. (2000). The tetraspanin CD9 associates with the integrin alpha6beta4 in cultured human epidermal keratinocytes and is involved in cell motility. Eur J Cell Biol 79:41-51.
11. Behr S, Schriever F. (1995). Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin alpha 4/beta 1 and fibronectin. J Exp Med 182:1191-1199.
12. Bell GM, Seaman WE, Niemi EC, Imboden JB. (1992). The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med 175:527-536.
13. Berdichevsky F, Alford D, D'Souza B, Taylor-Papadimitriou J. (1994). Branching morphogenesis of human mammary epithelial cells in collagen gels. J Cell Sci 107:3557-3568.
14. Berditchevski F, Odintsova L. (1999). Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. J Cell Biol 146:477-492.
15. Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME. (1997). A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem 272:2595-2598.
16. Boismenu R, Rhein M, Fischer WH, Havran WL. (1996). A role for CD81 in early T cell development. Science 271:198-200.
17. Borradori L, Sonnenberg A. (1999). Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol 112:411-418.
18. Bosca L, Lazo PA. (1994). Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages. J Exp Med 179:1119-1126.
19. Bronstein JM, Tiwari-Woodruff S, Buzkinov AG, Stevens DB. (2000). Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. J Neurosci Res 59:706-711.
20. Cajot JF, Sordat I, Silvesire T, Sordat B. (1997). Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells. Cancer Res 57:2593-2597.
21. Cao L, Yoshino T, Kawasaki N, Sakuma I, Takahashi K, Akagi T. (1997). Anti-CD53 monoclonal antibody induced LFA-1/ICAM-1-dependent and -independent lymphocyte homotypic cell aggregation. Immunobiology 197:70-81.
22. Carmo AM, Wright MD. (1995). Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity. Eur J Immunol 25: 2090-2095.
23. Chandrasekaran L, He CZ, Al-Barazi H, Krutzsch HC, Iruela-Arispe ML, Roberts DD. (2000). Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Mol Biol Cell 11:2885-2900.
24. Chang AC, Salomon DR, Wadsworth S, Hong MJ, Mojcik CF, Otto S, Shevach EM, Coligan JE. (1995). Alpha 3 beta 1 and alpha 6 beta 1 integrins mediate laminin/merosin binding and function as costimulatory molecules for human thymocyte proliferation. J Immunol 154:500-510.
25. Charrin S, LeNaour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein F. (2001). The major CD9 and CD81 molecular partner: Identification and characterization of the complexes. J Biol Chem 276:14329-14337.
26. Chen MS, Almeida EA, Huovila AP, Takahashi Y, Shaw LM, Mercurio AM, White JM. (1999). Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM. J Cell Biol 144: 549-561.
27. Chen MS, Tung KS, Coonrod SA, Takahashi Y, Bigler D, Chang A, Yamashita Y, Kincade PW, Herr JC, White JM. (1999). Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization. Proc Natl Acad Sci USA 96: 11830-11835.
28. Chintala SK, Sawaya R, Gokaslan ZL, Rao JS. (1996). Modulation of matrix metalloprotease-2 and invasion in human glioma cells by alpha 3 beta 1 integrin. Cancer Lett 103:201-208.
29. Cibotti R, Punt JA, Dash KS, Sharrow SO, Singer A. (1997). Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity 6:245-255.
30. Claas C, Stipp CS, Hemler ME. (2001). Evaluation of prototype TM4SF protein complexes and their relation to lipid rafts. J Biol Chem 276:7974-7984.
31. Cohen MW, Hoffstrom BC, DeSimone DW. (2000). Active zones on motor nerve terminals contain alpha 3 beta 1 integrin. J Neurosci 20:4912-4921.
32. Condic ML, Letourneau PC. (1997). Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth. Nature 389: 852-856.
33. Cook GA, Wilkinson DA, Crossno JT Jr, Raghow R, Jennings LK. (1999). The tetraspanin CD9 influences the adhesion, spreading, and pericellular fibronectin matrix assembly of Chinese hamster ovary cells on human plasma fibronectin. Exp Cell Res 251:356-371.
34. de Parseval A, Lerner DL, Borrow P, Willett BJ, Elder JH. (1997). Blocking of feline immunodeficiency virus infection by a monoclonal antibody to CD9 is via inhibition of virus release rather than interference with receptor binding. J Virol 71:5742-5749.
35. Deng J, Yeung VP, Tsitoura D, DeKruyff RH, Umetsu DT, Levy S. (2000). Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice. J Immunol 165:5054-5061.
36. Dijkstra S, Geisert EEJ, Gispen WH, Bar PR, Joosten EA. (2000). Up-regulation of CD81 (target of the antiproliferative antibody; TAPA) by reactive microglia and astrocytes after spinal cord injury in the rat. J Comp Neurol 428:266-277.
37. DiPersio CM, Shao M, Di Costanzo L, Kreidberg JA, Hynes RO. (2000). Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin-dependent secretion of MMP-9/gelatinase B. J Cell Sci 113:2909-2921.
38. Domanico SZ, Pelletier AJ, Havran WL, Quaranta V. (1997). Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate. Mol Biol Cell 8:2253-2265.
39. Domínguez-Jiménez C, Yáñez-Mó M, Carreira A, Tejedor R, González-Amaro R, Álvarez V, Sánchez-Madrid F. (2001). Involvement of α3 integrin/ tetraspanins complexes in the angiogenic response induced by Angiotensin II. FASEB J
40. Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barret JC. (1995). KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268: 884-886.
41. Dowling J, Yu QC, Fuchs E. (1996). Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 134:559-572.
42. Dulabon L, Olson EC, Taglienti MG, Eisenhuth S, McGrath B, Walsh CA, Kreidberg JA, Anton ES. (2000). Reelin binds alpha3beta1 integrin and inhibits neuronal migration. Neuron 27:33-44.
43. Fitter S, Sincock PM, Jolliffe CN, Ashman LK. (1999). Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion. Biochem J 338:61-70.
44. Flint M, Maidens C, Loomis-Price LD, Shotton C, Dubuisson J, Monk P, Higginbottom A, Levy S, McKeating JA. (1999). Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J Virol 73:6235-6244.
45. Frosyth KD. (1991). Anti-CD9 antibodies augment neutrophil adherence to endothelium. Immunology 72:292-296.
46. Frost EE, Buttery PC, Milner R, ffrench-Constant C. (1999). Integrins mediate a neuronal survival signal for oligodendrocytes. Curr Biol 9:1251-1254.
47. Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O. (1992). Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. J Virol 66:1394-1401.
48. Fukuyama R, Shimizu N. (1991). Detection of epidermal growth factor receptors and E-cadherins in the basolateral membrane of A431 cells by laser scanning fluorescence microscopy. Jpn J Cancer Res 82:8-11.
49. Garcia-Frigola C, Burgaya F, Calbet M, de Lecea L, Soriano E. (2000). Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures. Neuroreport 11:3181-3185.
50. Geisert EE Jr, Yang L, Irwin MH. (1996). Astrocyte growth, reactivity, and the target of the antiproliferative antibody, TAPA. J Neurosci 16:5478-5487.
51. Ghosh S, Brown R, Jones JC, Ellerbroek SM, Stack MS. (2000). Urinary-type plasminogen activator (uPA) expression and uPA receptor localization are regulated by alpha 3 beta 1 integrin in oral keratinocytes. J Biol Chem 275:23869-23876.
52. Goldfinger L, Stack M, Jones J. (1998). Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator. J Cell Biol 141:255-265.
53. Goldfinger LE, Hopkinson SB, DeHart GW, Collawn S, Couchman JR, Jones JC. (1999). The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci 112: 2615-2629.
54. Guo XZ, Friess H, Di Mola FF, Heinicke JM, Abou-Shady M, Graber HU, Baer HU, Zimmermann A, Korc M, Buchler MW. (1998). KAI1, a new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma. Hepatology 28:1481-1488.
55. Hadjiargyrou M, Kaprielian Z, Kato N, Patterson PH. (1996). Association of the tetraspan protein CD9 with integrins on the surface of S-16 Schwann cells. J Neurochem 67:2505-2513.
56. Hadjiargyrou M, Patterson PH. (1995). An anti-CD9 monoclonal antibody promotes adhesion and induces proliferation of Schwann cells in vitro. J Neurosci 15:574-583.
57. Hasegawa H, Nomura T, Kishimoto K, Yanagisawa K., Fujita S. (1998). SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily, associates preferentially with alpha 5 beta 1 integrin and regulates adhesion of human T cell leukemia virus type 1-infected T cells to fibronectin. J Immunol 161:3087-3095.
58. Heagy W, Duca K, Finberg RW. (1995). Enkephalins stimulate leukemia cell migration and surface expression of CD9. J Clin Invest 96:1366-1374.
59. Hebert C, Norris K, Della Coletta R, Reynolds M, Ordonez J, Sauk JJ. (1999). Cell surface colligin/ Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines. J Cell Biochem 73: 248-258.
60. Hemler ME. (1998). Integrin associated proteins. Curr Opin Cell Biol 10:578-585.
61. Higashiyama S, Iwamoto R, Goishi K, Raab G, Taniguchi N, Klagsbrun M, Mekada E. (1995). The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor. J Cell Biol 128:929-938.
62. Hodivala-Dilke KM, DiPersio CM, Kreidberg JA, Hynes RO. (1998). Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. J Cell Biol 142:1357-1369.
63. Hosokawa Y, Ueyama E, Morikawa Y, Maeda Y, Seto M, Senba E. (1999). Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons. Neurosci Res 35:281-290.
64. Ikeyama S, Koyama M, Yamaoko M, Sasada R, Miyake M. (1993). Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med 177: 1231-1237.
65. Imai T, Kakizaki M, Nishimura M, Yoshie O. (1995). Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J Immunol 155: 1229-1239.
66. Inui S, Higashiyama S, Hashimoto K, Higashiyama M, Yoshikawa K, Taniguchi N. (1997). Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth. J Cell Physiol 171:291-298.
67. Ivins JK, Yurchenco PD, Lander AD. (2000). Regulation of neurite outgrowth by integrin activation. J Neurosci 20:6551-6560.
68. Iwamoto R, Higashiyama S, Mitamura T, Taniguchi N, Klagsbrun M, Mekada E. (1994). Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which upregulates functional receptors and diphtheria toxin sensitivity. EMBO J 13:2322-2330.
69. Iwao M, Fukada S, Harada T, Tsujikawa K, Yagita H, Hiramine C, Miyagoe Y, Takeda S, Yamamoto H. (2000). Interaction of merosin (laminin 2) with very late activation antigen-6 is necessary for the survival of CD4+ CD8+ immature thymocytes. Immunology 99:481-488.
70. Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E. (1998). A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 17:7260-7272.
71. Jennings LK, Fox CF, Kouns WC, McKay CP, Ballou LR, Schultz HE. (1990). The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies. J Biol Chem 265:3815-3822.
72. Jones PH, Bishop LA, Watt FM. (1996). Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes. Cell Adhes Commun 4:297-305.
73. Kagawa T, Mekada E, Shishido Y, Ikenaka K. (1997). Immune system-related CD9 is expressed in mouse central nervous system myelin at a very late stage of myelination. J Neurosci Res 50:312-320.
74. Kaji K, Oda S, Shikano T, Ohnuki T, Uematsu Y, Sakagami J, Tada N, Miyazaki S, Kudo A. (2000). The gamete fusion process is defective in eggs of CD9-deficient mice. Nat Genet 24:279-282.
75. Kaprielian Z, Cho KO, Hadjiargyrou M, Patterson PH. (1995). CD9, a major platelet cell surface glycoprotein, is a ROCA antigen and is expressed in the nervous system. J Neurosci 15:562-573.
76. Kim LT, Yamada KM. (1997). Evidence that β1 integrins in keratinocyte cell-cell junctions are not in the ligand-occupied conformation. J Invest Dermatol 108:876-880.
77. Klein-Soyer C, Azorsa DO, Cazenave JP, Lanza F. (2000). CD9 participates in endothelial cell migration during in vitro wound repair. Arterioscler Throm Vasc Biol 20:360-369.
78. Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Lohler J, Zinkernagel RM, Horak I, Orinska Z. (2000). Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptinial costimulatory conditions. Mol Cell Biol 20:5363-5369.
79. Kondoh M, Ueda M, Ichihashi M, Mishima Y. (1993). Decreased expression of human melanoma-associated antigen ME491 along the progression of melanoma pre-canceroses to invasive and metastatic melanomas. Melanoma Res 3:241-245.
80. Kopczynski CC, Davis GW., Goodman CS. (1996). A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation. Science 271:1867-1870.
81. Kreidberg J, Donovan M, Goldstein S, Rennke H, Shepherd K, Jones R, Jaenisch R. (1996). Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122:3537-3547.
82. Kubota S, Ito H, Ishibashi Y, Seyama Y. (1997). Anti-alpha3 integrin antibody induces the activated form of matrix metalloprotease-2 (MMP-2) with concomitant stimulation of invasion through matrigel by human rhabdomyosarcoma cells, Int J Cancer 70:106-111.
83. Lagaudriere-Gesbert C, Le Naour F, Lebel-Binay S, Billard M, Lemichez E, Boquet P, Boucheix C, Conjeaud H, Rubinstein E. (1997). Functional analysis of four tetraspans, CD9, CD53, CD81, and CD82, suggests a common role in costimulation, cell adhesion, and migration: only CD9 upregulates HB-EGF activity. Cell Immnnol 182:105-112.
84. Lagaudriere-Gesbert C, Lebel-Binay S, Hubeau C, Fradelizi D, Conjeaud H. (1998). Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation. Eur J Immunol 28: 4332-4344.
85. Lampe PD, Nguyen BP, Gil S, Usui M, Olerud J, Takada Y, Carter WG. (1998). Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication. J Cell Biol 143: 1735-1747.
86. Lazo PA, Cuevas L, Gutierrez del Arroyo A, Orue E. (1997). Ligation of CD53/OX44, a tetraspan antigen, induces homotypic adhesion mediated by specific cell-cell interactions. Cell Immunol 178:132-140.
87. Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C. (2000). Severely reduced female fertility in CD9-deficient mice. Science 287:319-321.
88. Letarte M, Seehafer JG, Greaves A, Masellis-Smith A, Shaw AR. (1993). Homotypic aggregation of pre-B leukemia cell lines by antibodies to VLA integrins correlates with their expression of CD9. Leukemia 7:93-103.
89. Levy S, Todd SC, Maecker HT. (1998). CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol 16:89-109.
90. Loffler S, Lottspeich F, Lanza F, Azorsa DO, ter Meulen V, Schneider-Schaulies J. (1997). CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus. J Virol 71:42-49.
91. Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC. (1999). Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res 59: 5724-5731.
92. Lozahic S, Christiansen D, Manie S, Gerlier D, Billard M, Boucheix C, Rubinstein E. (2000). CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. Eur J Immunol 30:900-907.
93. Lunardi C, Bason C, Navone R, Millo E, Damonte G, Corrocher R, Puccetti A. (2000). Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells. Nat Med 6: 1183-1186.
94. Maecker HT, Do MS, Levy S. (1998). CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses. Proc Natl Acad Sci USA 95:2458-2462.
95. Maecker HT, Levy S. (1997). Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J Exp Med 185:1505-1510.
96. Maecker HT, Todd SC, Levy S. (1997). The tetraspanin superfamily: molecular facilitators. FASEB J 11:428-442.
97. Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG. (1997). The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J 16:2365-2375.
98. Masellis-Smith A, Jensen GS, Seehafer JG, Slupsky JR, Shaw AR. (1990). Anit-CD9 monoclonal antibodies induce homotypic adhesion of pre-B cell lines by a novel mechanism. J Immunol 144:1607-1613.
99. Masellis-Smith A, Shaw AR. (1994). CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J Immuno 152:2768-2777.
100. Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT. (1993). Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. J Exp Med 178:1407-1417.
101. Melchiori A, Mortarini R, Carlone S, Marchisio PC, Anichini A, Noonan DM, Albini A. (1995). The alpha 3 beta 1 integrin is involved in melanoma cell migration and invasion. Exp Cell Res 219:233-242.
102. Meola A, Sbardellati A, Bruni Ercole B, Cerretani M, Pezzanera M, Ceccacci A, Vitelli A, Levy S, Nicosia A, Traboni C, McKeating J, Scarselli E. (2000). Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J Virol 74:5933-5938.
103. Miller BJ, Georges-Labouesse E, Primakoff P, Myles DG. (2000). Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent. J Cell Biol 149:1289-1296.
104. Miyado K, Yamada G, Yamada S, Hasuwa H, Nakamura Y, Ryu F, Suzuki K, Kosai K, Inoue K, Ogura A, Okabe M, Mekada E. (2000). Requirement of CD9 on the egg plasma membrane for fertilization. Science 287:321-324.
105. Miyake M, Koyama M, Seno M, Ikeyama S. (1991). Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. J Exp Med 174:1347-1354.
106. Miyake M, Nakano K, Itoi SI, Koh T, Taki T. (1996). Motility-related protein-1 (MRP-1/CD9) reduction as a factor of poor prognosis in breast cancer. Cancer Res 56:1244-1249.
107. Miyamoto S, Teramoto H, Coso OA, Gutkind JS, Burbelo PD, Akiyama SK, Yamada KM. (1995). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol 131:791-805.
108. Miyazaki T, Muller U, Campbell KS. (1997). Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J 16:4217-4225.
109. Mollinedo F, Fontan G, Barasoain I, Lazo PA. (1997). Recurrent infectious diseases in human CD53 deficiency. Clin Diagn Lab Immunol 4:229-231.
110. Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, Mortarini R, Noonan DM, Natali PG, Albini A. (2000). The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity, Int J Cancer 87: 336-342.
111. Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L, Pineiro-Sanchez M, Nakahara H, Yeh Y, Chen WT. (1999). A novel protease-docking function of integrin at invadopodia. J Biol Chem 274: 24947-24952.
112. Nakamura K, Iwamoto R, Mekada E. (1995). Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites. J Cell Biol 129:1691-1705.
113. Nakamura K, Mitamura T, Takahashi T, Kobayashi T, Mekada E. (2000). Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity. J Biol Chem 275:18284-18290.
114. Nakamura Y, Iwamoto R, Mekada E. (1996). Expression and distribution of CD9 in myelin of the central and peripheral nervous systems. Am J Pathol 149:575-583.
115. Natali PG, Nicotra MR, Bartolazzi A, Cavaliere R, Bigotti A. (1993). Integrin expression in cutaneous malignant melanoma: association of the alpha 3/beta 1 heterodimer with tumor progression, Int J Cancer 54:68-72.
116. Nath D, Slocombe PM, Webster A, Stephens PE, Docherty AJ, Murphy G. (2000). Meltrin gamma-(ADAM-9) mediates cellular adhesion through alpha(6)beta(1)integrin, leading to a marked induction of fibroblast cell motility. J Cell Sci 113:2319-2328.
117. Nguyen BP, Ryan MC, Gil SG, Carter WG. (2000). Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr Opin Cell Biol 12:554-562.
118. Nichols TC, Guthridge JM, Karp DR, Molina H, Fletcher DR, Holers VM. (1998). Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes. Eur J Immunol 28: 4123-4129.
119. Nishida M, Miyagawa J, Yamashita S, Higashiyama S, Nakata A, Ouchi N, Tamura R, Yamamori K, Kihara S, Taniguchi N, Matsuzawa Y. (2000). Localization of CD9, an enhancer protein for proheparin-binding epidermal growth factor-like growth factor, in human atherosclerotic plaques: possible involvement of juxtacrine growth mechanism on smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol 20:1236-1243.
120. Nylander N, Smith L, Underwood R, Piepkorn M. (1998). Topography of amphiregulin expression in cultured human keratinocytes: colocalization with the epidermal growth factor receptor and CD44. In Vitro Cell Dev Biol Anim 34:182-188.
121. Odintsova E, Sugiura T, Berditchevski F. (2000). Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr Biol 10:1009-1012.
122. Ohta H, Tsurudome M, Matsumura H, Koga Y, Morikawa S, Kawano M, Kusugawa S, Komada H, Nishio M, Ito Y. (1994). Molecular and biological characterization of fusion regulatory proteins (FRPs): anti-FRP mAbs induced HIV-mediated cell fusion via an integrin system. EMBO J 13:2044-2055.
123. Olweus J, Lund-Johansen F, Horejsi V. (1993). CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J Immunol 151:707-716.
124. Oritani K, Wu X, Medina K, Hudson J, Miyake K, Gimble JM, Burstein SA, Kincade PW. (1996). Antibody ligation of CD9 modifies production of myeloid cells in long-term cultures. Blood 87:2252-2261.
125. Ouchi N, Kihara S, Yamashita S, Higashiyama S, Nakagawa T, Shimomura I, Funahashi T, Kameda-Takemura K, Kawata S, Taniguchi N, Matsuzawa Y. (1997). Role of membrane-anchored heparin-binding epidermal growth factor-like growth factor and CD9 on macrophages. Biochem J 328:923-928.
126. Peduzzi JD, Grayson TB, Fischer FR, Geisert EE Jr. (1999). The expression of TAPA (CD81) correlates with the reactive response of astrocytes in the developing rat CNS. Exp Neurol 160:460-468.
127. Peñas PF, García-Díez A, Sánchez-Madrid F, Yáñez-Mó M. (2000). Tetraspanins are localized at motilily-related structures and involved in normal human keratinocyte wound healing migration. J Invest Dermatol 114:1126-1135.
128. Peñas PF, Gómez M, Bueno GF, Rios L, Yáñez-Mó M, Cabañas C, Sánchez-Madrid F, García-Díez A. (1998). Differential expression of activation epitopes of β1 integrins in psoriasis and normal skin. J Invest Dermatol 111:19-24.
129. Perron JC, Bixby JL. (1999). Tetraspanins expressed in the embryonic chick nervous system. FEBS Lett 461:86-90.
130. Piepkoni M, Pittelkow MR, Cook PW. (1998). Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidennal growth factor-related growth factors. J Invest Dermatol 111:715-721.
131. Pileri P, Uematsu Y, Campagnoli S, Galli G, Falugi F. Petracca R, Weiner AJ, Houghton M, Rosa D, Grandi G, Abrignani S. (1998). Binding of hepatitis C virus to CD81. Science 282:938-941.
132. Pique C, Lagaudriere-Gesbert C, Delamarre L, Rosenberg AR, Conjeaud H, Dokhelar MC. (2000). Interaction of CD82 tetraspanin proteins with HTLV-1 envelope glycoproteins inhibits cell-to-cell fusion and virus transmission, Virology 276:455-465.
133. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. (1999). eGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888.
134. Pujades C, Alon R, Yauch R, Masumoto A, Burkly L, Chen C, Springer T, Lobb R, Hemler M. (1997). Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding. Mol Biol Cell 8:2647-2657.
135. Rabinovitz I, Mercurio AM. (1997). The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol 139:1873-1884.
136. Rabinovitz I, Toker A, Mercurio AM. (1999). Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol 146:1147-1160.
137. Radford KJ, Mallesch J, Hersey P. (1995). Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491). Int J Cancer 62:631-635.
138. Radford KJ, Thorne RF, Hersey P. (1997). Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line. J Immnuol 158:3353-3358.
139. Ramarli D, Scupoli MT, Fiorini E, Poffe O, Brentegani M, Villa A, Cecchini G, Tridente G, Marchisio PC. (1998). Thymocyte contact or monoclonal antibody-mediated clustering of 3beta1 or 6beta4 integrins activate interleukin-6 (IL-6) transcription factors (NF-kappaB and NF-IL6) and IL-6 production in human thymic epithelial cells. Blood 92: 3745-3755.
140. Rasmussen AM, Blomhoff HK, Stokke T, Horejsi V, Smeland EB. (1994). Cross-linking of CD53 promotes activation of resting human B lymphocytes. J Immunol 153:4997-5007.
141. Roberts JJ, Rodgers SE, Drury J, Ashman LK, Lloyd JV. (1995). Platelet activation induced by a murine monoclonal antibody directed against a novel tetraspan antigen. Br J Haematol 89:853-860.
142. Rubinstein E, Le Naour F, Billard M, Prenant M, Boucheix C. (1994). CD9 antigen is an accessory subunit of the VLA integrin complexes. Eur J Immunol 24:3005-3013.
143. Rubinstein E, Le Naour E, Lagaudriere-Gesbert C, Billard M, Conjeaud H, Boucheix C. (1996). CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur J Immunol 26:2657-2665.
144. Schmid E, Zurbriggen A, Gassen U, Rima B, ter Meulen V, Schneider-Schaulies J. (2000). Antibodies to CD9, a tetraspan transmembrane protein, inhibit canine distemper virus-induced cell-cell fusion but not virus-cell fusion. J Virol 74:7554-7561.
145. Schmidt C, Kunemund V, Wintergerst ES, Schmitz B, Schachner M. (1996). CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1. J Neurosci Res 43:12-31.
146. Scupoli MT, Fiorini E, Marchisio PC, Poffe O, Tagliabue E, Brentegani M, Tridente G, Ramarli D. (2000). Lymphoid adhesion promotes human thymic epithelial cell survival via NF-(kappa)B activation. J Cell Sci 113:169-177.
147. Sechi AS, Wehland J. (2000). The actin cytoskeleton and plasma membrane connection: Ptdlns(4,5)P(2) influences cytoskeletal protein activity at the plasma membrane. J Cell Sci 113:3685-3695.
148. Seehafer JG, Shaw AR. (1991). Evidence that the signal-initiating membrane protein CD9 is associated with small GTP-binding proteins. Biochem Biophys Res Commun 179:401-400.
149. Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. (1919). Selective tetraspin-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. Biochem J 340:103-111.
150. Shaw AR, Domanska A, Mak A, Gilchrist A, Dobler K, Visser L, Poppema S, Fliegel L, Letarte M, Willett BJ. (1995). Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motilily on fibronectin and laminin substrates and enhanced tyrosine phosphorylation. J Biol Chem 270:24092-24099.
151. Shaw LM, Rabinovitz I, Wang HH, Toker A, Mercurio AM. (1997). Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91:949-960.
152. Shi W, Fan H, Shum L, Derynck R. (2000). The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor
153. Shibagaki N, Hanada K, Yamaguchi S, Yamashita H, Shimada S, Hamada H. (1998). Functional analysis of CD82 in the early phase of T cell activation: role in cell adhesion and signal transduction. Eur J Immunol 28:1125-1133.
154. Shibagaki N, Hanada K, Yamashita H, Shimada S, Hamada H. (1999). Overexpression of CD82 on human T cells enhances LFA-1/ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation. Eur J Immunol 29:4081-4091.
155. Si Z, Hersey P. (1993). Expression of the neuroglandular antigen and analogues in melanoma. CD9 expression appears inversely related to metastatic potential of melanoma. Int J Cancer 54:37-43.
156. Simons K, Toomre D. (2000). Lipid rafts and signal transduction. Nature Rev 1:31-39.
157. Sincock PM., Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK. (1999). PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J Cell Sci 112: 833-844.
158. Skubitz KM, Campbell KD, Iida J, Skubitz AP. (1996). CD63 associates with tyrosine kinase activity and CD11/CD18. and transmits an activation signal in neutrophils. J Immunol 157:3617-3626.
159. Stahl S, Weitzman S, Jones JG. (1997). The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis. J Cell Sci 110:55-63.
160. Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A. (2000). The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol 149:969-982.
161. Stipp CS, Hemler ME. (2000). Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. J Cell Sci 113:1871-1882.
162. Stipp CS, Orlicky DJ, Hemler ME. (2001). FPRP: A major, highly stoichiometric, highly specific CD81 and CD9-associated protein. J Biol Chem 276:4853-4862.
163. Stonehouse TJ, Woodhead VE, Herridge PS, Ashrafian H, George M, Chain BM, Katz DR. (1999). Molecular characterization of U937-dependent T-cell co-stimulation. Immunology 96:35-47.
164. Sugiura T, Berditchevski F. (1999). Function of alpha3beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2). J Cell Biol 146:1375-1389.
165. Sullivan CD, Geisert EE Jr. (1998). Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain. J Comp Neurol 396:366-380.
166. Symington BE, Carter WG. (1995). Modulation of epidermal differentiation by epiligrin and integrin alpha 3 beta 1. J Cell Sci 108:831-838.
167. Tachibana I, Hemler ME. (1999). Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J Cell Biol 146:893-904.
168. Tai XG, Toyooka K, Yashiro Y, Abe R, Park CS, Hamaoka T, Kobayashi M, Neben S, Fujiwara H. (1997). CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis. J Immunol 159:3799-3807.
169. Tai XG, Yashiro Y, Abe R, Toyooka K, Wood CR, Morris J, Long A, Ono S, Kobayashi M, Hamaoka T, Neben S, Fujiwara H. (1996). A role for CD9 molecules in T cell activation. J Exp Med 184:753-758.
170. Takaoka A, Hinoda Y, Satoh S, Adachi Y, Itoh F, Adachi M, Imai K. (1998). Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. Oncogene 16:1443-1453.
171. Tanaka Y, Fukudome K, Hayashi M, Takagi S, Yoshie O. (1995). Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult T-cell-leukemia cell lines, Int J Cancer 60: 554-561.
172. Taraboletti G, Morbidelli L, Donnini S, Parenti A, Granger H, Giavazzi R, Ziche M. (2000). The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells. FASEB J 14:1674-1676.
173. Testa JE, Brooks PC, Lin JM, Quigley JP. (1999). Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. Cancer Res 59:3812-3820.
174. Todd SC, Lipps SG, Crisa L, Salomon DR, Tsoukas CD. (1996). CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation. J Exp Med 184:2055-2060.
175. Tole S, Patterson PH. (1993). Distribution of CD9 in the developing and mature rat nervous system. Dev Dyn 197:94-106.
176. Toothill VJ, Van Mourik JA, Niewenhuis HK, Metzelaar MJ, Pearson JD. (1990). Characterization of the enhanced adhesion of neutrophil leukocytes to thrombin-stimulated endothelial cells. J Immunol 145:283-291.
177. Tsitsikov EN, Gutierrez-Ramos JG, Geha RS. (1997). Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mire. Proc Natl Acad Sci USA 94:10844-10849.
178. Uchida S, Shimada Y, Watanabe G, Li ZG, Hong T, Miyake M, Imamura M. (1999). Motility-relatod protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer 79:1168-1173.
179. Vischer UM, Wagner DD. (1993). CD63 is a component of Weibel-Palade bodies of human endothelial cells. Blood 82:1184-1191.
180. Vivinus-Nebot M, Ticchioni M, Mary F, Hofman P, Quaranta V, Rousselle P, Bernard A. (1999). Laminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrins. J Cell Biol 144: 563-574.
181. von Andrian UH, Hasslen SR, Nelson RD, Erlandsen SL, Butcher EC. (1995). A central role for microvillous receptor presentation in leukocyte adhesion under flow. Cell 82:989-999.
182. Wang Z, Symons JM, Goldstein SL, McDonald A, Miner JH, Kreidberg JA. (1999). (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization. J Cell Sci 112:2925-2935.
183. Willett B, Hosie M, Shaw A, Neil J. (1997). Inhibition of feline immunodeficiency virus infection by CD9 antibody operates after virus entry and is independent of virus tropism. J Gen Virol 78:611-618.
184. Witherden DA, Boismenu R, Havran WL. (2000). CD81 and CD28 costimulate T cells through distinct pathways. J Immunol 165:1902-1909.
185. Wright M, Tomlinson M. (1994). The ins and outs of the transmembrane 4 superfamily. Immunol Today 15:588-594.
186. Wu XR, Medina JJ, Sun TT. (1995). Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. J Biol Chem 270:29752-29759.
187. Yagami-Hiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshinia Y, Fujisawa-Sehara A. (1995). A metalloprotease-disintegrin participating in myoblast fusion. Nature 377:652-656.
188. Yang X, Wei L, Tang C, Slack R, Montgomery E, Lippman M. (2000). KAI1 protein is down-regulated during the progression of human breast cancer. Clin Cancer Res 6:3424-3429.
189. Yáñez-Mó M, Alfranca A, Cabanas C, Marazuela M, Tejedor R, Ursa MA, Ashman LK, de Landázuri MO, Sánchez-Madrid F. (1998). Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions. J Cell Biol 141:791-804.
190. Yáñez-Mó M, Tejedor R, Rousselle P, Sánchez-Madrid F. (2001). Tetraspanins in intercellular adhesion of polarized epithelial cells: spatial and functional relationship to integrins and cadherhis. J Cell Sci 114:577-587.
191. Yashiro-Ohtani Y, Zhou XY, Toyo-Oka K, Tai XG, Park CS, Hamaoka T, Abe R, Miyake K, Fujiwara II. (2000). Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts. J Immunol 164:1251-1259.
192. Yauch RL, Berditchevski F, Harler MB, Reichner J, Hemler ME. (1998). Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell 9:2751-2765.
193. Yauch RL, Hemler ME. (2000). Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J 351: 629-637.
194. Yauch RL, Kazarov AR, Desai B, Lee RT, Hemler ME. (2000). Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem 275:9230-9238.
195. Yu X, Miyamoto S, Mekada F. (2000), Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites. J Cell Sci 113:2139-2147.
196. Zemni R, Bienvenu T, Vinet MC, Sefiani A, Carrie A, Billuart P, McDonell N, Couvert P, Francis F, Chafey P, Fauchereau F, Friocourt G, Portes V, Cardona A, Frints S, Meindl A, Brandau O, Ronce N, Moraine C, Bokhoven H, Ropers HH, Sudbrak R, Kahn A, Fryns JP, Beldjord C, Chelly J. (2000). A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Nat Genet 24:167-170.
197. Zharig K, Kramer RH. (1996). Laminin 5 deposition promotes keratinocyte motility. Exp Cell Res 227:309-322.