The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 3, 2005, Pages 1639-1643

  Weigert, Cora ^a   Thamer, Claus ^a   Brodbeck, Katrin ^a   Guirguis, Alke ^a   Machicao, Fausto ^a   Machann, Jürgen ^a   Schick, Fritz ^a   Stumvoll, Michael ^a   Fritsche, Andreas ^a   Häring, Hans U ^a   Schleicher, Erwin D ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOKINASE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HEXOSAMINE;

ADULT; AEROBIC CAPACITY; ALLELE; ARTICLE; BODY FAT; BODY MASS; CAUCASIAN; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY METABOLISM; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC SCREENING; GENOTYPE; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; TIBIALIS ANTERIOR MUSCLE; GENETICS; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; LIPID METABOLISM; METABOLISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ENERGY METABOLISM; FEMALE; GENOTYPE; GLUCOSE CLAMP TECHNIQUE; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); HEXOSAMINES; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 20144387498     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0058     Document Type: Article

References (28)

1. McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ 1992 Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. J Biol Chem 267:25208-25212
2. Kreppel LK, Blomberg MA, Hart GW 1997 Dynamic glycosylation of nuclear and cytosolic proteins. J Biol Chem 272:9308-9315
3. Marshall S, Bacote V, Traxinger RR 1991 Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 266:4706-4712
4. McClain DA, Crook ED 1996 Perspectives in diabetes. Hexosamines and insulin resistance. Diabetes 45:1003-1009
5. Robinson KA, Weinstein ML, Lindenmayer GE, Buse MG 1995 Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver. Diabetes 44:1438-1446
6. Path ME, Virkamaki A, Landaker EJ, Kahn CR, Yki-Jarvinen H 1999 Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes 48:1562-1571
7. Hawkins M, Barzilai N, Liu R, Hu M, Chen W, Rossetti L 1997 Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest 99:2173-2182
8. Hebert Jr LF, Daniels MC, Zhou J, Crook ED, Turner RL, Simmons ST, Neidigh JL, Zhu JS, Baron AD, McClain DA 1996 Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance. J Clin Invest 98:930-936
9. Buse MG, Robinson KA, Gettys TW, McMahon EG, Gulve EA 1997 Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice. Am J Physiol 272:E1080-E1088
10. Obici S, Wang J, Chowdury R, Feng Z, Siddhanta U, Morgan K, Rossetti L 2002 Identification of a biochemical link between energy intake and energy expenditure. J Clin Invest 109:1599-1605
11. Rossetti L 2000 Perspective: hexosamines and nutrient sensing. Endocrinology 141:1922-1925
12. Weigert C, Brodbeck K, Lehmann R, Haring HU, Schleicher ED 2001 Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-β1 synthesis in NIH-3T3 fibroblasts. FEBS Lett 488:95-99
13. Weigert C, Friess U, Brodbeck K, Haering HU, Schleicher ED 2003 Glutamine:fructose-6-phosphate amino-transferase enzyme activity is necessary for the induction of TGF-β1 and fibronectin expression in mesangial cells. Diabetologia 46:852-855
14. Weigert C, Klopfer K, Kausch C, Brodbeck K, Stumvoll M, Haring HU, Schleicher ED 2003 Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase. Diabetes 52:650-656
15. Paterson AJ, Kudlow JE 1995 Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose. Endocrinology 136:2809-2816
16. James LR, Ingram A, Ly H, Thai K, Cai L, Scholey JW 2001 Angiotensin II activates the GFAT promoter in mesangial cells. Am J Physiol 281:F151-F162
17. Nerlich AG, Sauer U, Kolm-Litry V, Wagner E, Koch M, Schleicher ED 1998 Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes. Diabetes 47:170-178
18. Thamer C, Stumvoll M, Niess A, Tschritter O, Haap M, Becker R, Shirkavand R, Bachmann O, Rett K, Volk A, Häring H, Fritsche A 2003 Reduced skeletal muscle oxygen uptake and reduced β-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes. Diabetes Care 26:2126-2132
19. 12Ala polymorphism in the peroxisome proliferator activated receptor g2 gene is associated with increased antilipolytic insulin sensitivity. Diabetes 50:876-881
20. NIH Consensus Conference on Bioelectric Impedance 1994 http://consensus.nih.gov/ta/015/015_statement.htm. Accessed 14 February 2002
21. WHO: WHO Expert Committee on Diabetes Mellitus 1980 Second report. Tech Rep Ser 646. Geneva: WHO
22. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT 1999 Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276:E977-E989
23. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU 1999 Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119
24. Thamer C, Machann J, Bachmann O, Haap M, Dahl D, Wietek B, Tschritter O, Niess A, Brechtel K, Fritsche A, Claussen C, Jacob S, Schick F, Haring HU, Stumvoll M 2003 Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab 88:1785-1791
25. Oberkofler H, Holzl B, Esterbauer H, Xie M, Iglseder B, Krempler F, Paulweber B, Patsch W 2003 Peroxisome proliferator-activated receptor-γ coactivator-1 gene locus: associations with hypertension in middle-aged men. Hypertension 41:368-372
26. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN 2003 Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177-182
27. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K 2002 A comprehensive review of genetic association studies. Genet Med 4:45-61
28. Quandt K, Frech K, Karas H, Wingender E, Werner T 1995 MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 23:4878-4884