Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 23, 2004, Pages 5907-5911

  Shankaran, K ^a   Donnelly, Karla L ^a   Shah, Shrenik K ^a   Caldwell, Charles G ^a   Chen, Ping ^a   Hagmann, William K ^a   MacCoss, Malcolm ^a   Humes, John L ^a   Pacholok, Stephen G ^a   Kelly, Theresa M ^a   Grant, Stephan K ^a   Wong, Kenny K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

NOS synthase

Indexed keywords

ALKANE DERIVATIVE; DIAZEPANE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXAZEPANE DERIVATIVE; THIAZEPANE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BECKMANN REARRANGEMENT; COMPARATIVE STUDY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; OXIDATION; STRUCTURE ACTIVITY RELATION;

AZIRINES; DIHYDROPYRIDINES; ENZYME INHIBITORS; HUMANS; NITRIC OXIDE SYNTHASE; OXAZEPINES; THIAZEPINES;

EID: 7044269371     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.019     Document Type: Article

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