Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 3, 2000, Pages 324-330

  Hamilton, Steven P ^a   Haghighi, Fatemeh ^a   Heiman, Gary A ^a   Klein, Donald F ^a   Hodge, Susan E ^a,b   Fyer, Abby J ^a   Weissman, Myrna M ^a   Knowles, James A ^a,c  

^a New York State Psychiatric Institute ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Association; Dopamine; Linkage; Panic disorder; Polymorphism

Indexed keywords

DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER;

ARTICLE; FAMILY STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PANIC; PRIORITY JOURNAL;

ALLELES; CARRIER PROTEINS; CHI-SQUARE DISTRIBUTION; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PANIC DISORDER; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; REPRODUCIBILITY OF RESULTS; SEX FACTORS; TANDEM REPEAT SEQUENCES;

ANIMALIA;

EID: 0034640680     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20000612)96:3<324::AID-AJMG18>3.0.CO;2-W     Document Type: Article

References (59)

1. Anthony JC, Tien AY, Petronis KR. 1989. Epidemiologic evidence on cocaine use and panic attacks. Am J Epidemiol 129:543-549.
2. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65:1157-1165.
3. Asghari V. Schoots O, van Kats S, Ohara K, Jovanovic V, Guan HC, Bunzow JR, Petronis A, Van Tol HH. 1994. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 46:364-373.
4. Benjamin J, Gulman R, Osher Y, Segman R, Ebstein RP. 1997. Dopamine D4 receptor polymorphism assocated with panic disorder. Am J Med Genet (Neuropsychiatr Genet) 74:613.
5. Biederman J, Faraone SV, Keenan K, Benjamin J, Krifcher B, Moore C, Sprich-Buckminster S, Ugaglia K, Jellinek MS, Steingard R. 1992. Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples. Arch Gen Psychiatr 49:728-738.
6. Billett EA, Richter MA, Sam F, Swinson RP, Dai XY, King N, Badri F, Sasaki T, Buchanan JA, Kennedy JL. 1998. Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatr Genet 8:163-169.
7. Biró É, Penke B, Telegdy G. 1997. Role of different neurotransmitter systems in the cholecystokinin octapeptide-induced anxiogenic response in rats. Neuropeptides 31:281-285.
8. Catalano M, Mobile M, Novelli E, Nothen MM, Smeraldi E. 1993. Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol Psychiatry 34:459-464.
9. Chang FM, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK. 1996. The world-wide distribution of allele frequencies at the human dopamine 4 receptor locus. Hum Genet 98:91-101.
10. Cichon S, Nothen MM, Catalano M, Di Bella D, Maier W, Lichtermann D, Minges J, Albus M, Borrmann M, Franzek E. 1995. Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene. Psychiatr Genet 5:97-103.
11. Cohen P, Cohen J, Kasen S, Velez CN, Hartmark C, Johnson J, Rojas M, Brook J, Streuning EL. 1993. An epidemiological study of disorders in late childhood and adolescence. I. Age-and gender-specific prevalence. J Child Psychol Psychiatry 34:851-867.
12. Cook EH Jr, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL. 1995. Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 56:993-998.
13. Cottingham RW Jr, Idury RM, Schaffer AA. 1993. Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263.
14. Crawford F, Hoyne J, Diaz P, Osborne A, Dorotheo J, Sheehan D, Mullan. 1995. Occurrence of the Cys311 DRD2 variant in a pedigree multiply affected with panic disorder. Am J Med Genet 60:332-334.
15. Crowe RR, Wang Z, Noyes RJ, Albrecht BE, Darlison MG, Bailey ME, Johnson KJ, Zoega T. 1997. Candidate gene study of eight GABAA receptor subunits in panic disorder. Am J Psychiatry 154:1096-1100.
16. Cruz C, Camarena B, King N, Paez F, Sidenberg D, de la Fuente JR, Nicolini H. 1997. Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. Neurosci Lett 231:1-4.
17. Daly G, Hawi Z, Fitzgerald M, Gill M. 1999. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 4:192-196.
18. Ericksson E, Westberg P, Ailing C, Thuresson K, Modigh K. 1991. Cerebrospinal fluid levels of monoamine metabolites in panic disorder. Psychiatry Res 36:243-251.
19. Espejo EF. 1997. Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze. Brain Res 762:281-284.
20. Falk CT, Rubinstein P. 1987. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233.
21. Fyer AJ, Weissman MM. 1999. Genetic linkage study of panic: clinical methodology and description of pedigrees. Am J Med Genet (Neuropsychiatr Genet) 88:173-181.
22. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M. 1997. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313.
23. Hamilton SP, Heiman GA, Haghighi F, Mick S, Klein DF, Hodge SE, Weissman MM, Fyer A.J., Knowles JA. 1999. Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatric Genetics 9:1-6.
24. Ishiguro H, Arinami T, Yamada K, Otsuka Y, Toru M, Shibuya H. 1997. An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population. Psychiatry Clin Neurosci 51:333-335.
25. Johnson MR, Lydiard RB, ZeaLberg JJ, Fossey MD, Ballenger JC. 1994. Plasma and CSF HVA levels in panic patients with comorbid social phobia. Biol Psychiatry 36:425-427.
26. Kang AM, Palmatier MA, Kidd KK. 1999. Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3). Biol Psychiatry 46:151-160.
27. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. 1997. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 94:4572-4575.
28. Kato T, Wang ZW, Zoega T, Crowe RR. 1996. Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder. Am J Med Genet 67:401-405.
29. Kellner M, Wiedemann K, Krieg J-C, Holsboer F. 1994. Effects of the dopamine autoreceptor agonist in patients with depression and panic disorder. Neuropsychopharmacology 10:101S.
30. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. 1993. Panic disorder in women: a population-based twin study. Psychol Med 23: 397-406.
31. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus GM, Rassnick H, Preud'homme-Rivelli X, et al. 1998. Results of a genomewide genetic screen for panic disorder. Am J Med Genet (Neuropsychiatr Genet ) 81:139-147.
32. Knowles JA, Vieland VJ, Gilliam TC. 1992. Perils of gene mapping with microsatellite markers. Am J Hum Genet 51:905-909.
33. Knowles JA, Weissman MM. 1995. Panic disorder and agoraphobia. In Oldham JM, Riba MB, editors. Review of psychiatry, vol. 14. Washington, DC: American Psychiatric Press. p 383-404.
34. Lichter JB, Barr CL, Kennedy JL, Van Tol HH, Kidd KK, Livak KJ. 1993. A hypervariable segment, in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 2:767-773.
35. Mannuzza S, Fyer AJ, Endicott J, Klein DF. 1985. Family Informant schedule and criteria. New York: Anxiety Disorders Clinic, New York State Psychiatric Institute.
36. Mannuzza S, Fyer AJ, Klein DF, Endicott J. 1986. Schedule For Affective Disorders and Schizophrenia - Lifetime Version modified for the study of anxiety disorders (SADS-LA). Rationale and conceptual development. J Psychiatr Res 20:317-325.
37. Ohara K, Xie DW, Ishigaki T, Deng ZL, Nakamura Y, Suzuki Y, Miyasato K. 1996. The genes encoding the 5HT1D alpha and 5HT1D beta receptors are unchanged in patients with panic disorder. Biol Psychiatry 39:5-10.
38. Ott J. 1989. Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86:4175-4178.
39. Ott J. 1999. Analysis of human genetic linkage. Baltimore: Johns Hopkins University Press.
40. Perrin S, Last CG. 1996. Relationship between ADHD and anxiety in boys: results from a family study. J Am Acad Child Adolesc Psychiatry 35: 988-996.
41. Pitchot W, Ansseau M, Moreno AG, Hansenne M, von Frenckell R. 1992. dopaminergic function in panic disorder: comparison with major and minor depression. Biol Psychiatry 32:1004-1011.
42. Rowe DC, Stever C, Gard JM, Cleveland HH, Sanders ML, Abramowitz A, Kozol ST, Mohr JH, Sherman SL, Waldman ID. 1998. The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behav Genet 28:215-225.
43. Roy-Byrne PP, Uhde TW, Sack DA, Linnoila M, Post RM. 1986. Plasma HVA and anxiety in patients with panic disorder. Biol Psychiatry 21: 847-849.
44. Schaffer AA, Gupta SK, Shriram K, Cottingham RW Jr. 1994. Avoiding recomputation in linkage analysis. Hum Hered 44:225-237.
45. Schneider P, Evans L, Ross-Lee L, Wiltshire B, Eadie M, Kenardy J, Hoey H. 1987. Plasma biogenic amine levels in agoraphobia with panic attacks. Pharmacopsychiatry 20:102-104.
46. Sham PC, Curtis D. 1995. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59(Pt 1):97-105.
47. Sheehan DV, Davidson J, Manschreck T, Van Wyck Fleet J. 1983. Lack of efficacy of a new antidepressant (bupropion) in the treatment of panic disorder with phobias. J Clin Psychopharmacol 3:28-31.
48. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
49. 3 dopamine receptor-deficient mouse: evidence for reduced anxiety. Physiol Behav 63:137-141.
50. Steinlein OK, Deckert J, Nothen MM, Franke P, Maier W, Beckmann H, Propping P. 1997. Neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and panic disorder: an association study. Am J Med Genet 74:199-201.
51. Tannock R, Ickowicz A, Schachar R. 1995. Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. J Am Acad Child Adolesc Psychiatry 34:888-896.
52. Terwilliger JD. 1994. The available possibilities to analyze data of polygenic disease statistically. In Abstract to IVth Workshop of the Nordic Genome Initiative. Helsinki.
53. Terwilliger JD. 1995. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56:777-787.
54. Terwilliger JD, Ott J. 1992. A haplotype-based "haplotype relative risk" approach to detecting allelic associations. Hum Hered 42:337-346.
55. Van Tol HH, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O, Kennedy J, Seeman P, Niznik HB, Jovanovic V. 1992. Multiple dopamine D4 receptor variants in the human population. Nature 358:149-152.
56. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, Sanders ML, Gard JM, Stever C. 1998. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. AmJ Hum Genet 63:1767-1776.
57. -36CT) with panic disorder. Am J Med Genet (Neuropsychiatr Genet) 81:228-234.
58. Weeks DE, Ott J, Lathrop GM. 1990. SLINK: a general simulation program for linkage analysis. Am J Hum Genet 47:A204.
59. Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu H-G, Joyce PR, Karam EG, Lee C-K, Lellouch J, et al. 1997. The crossnational epidemiology of panic disorder. Arch Gen Psychiatry 54:305-309.