No association between 12 dopaminergic genes and schizophrenia in a large Dutch sample

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 134 B, Issue 1, 2005, Pages 6-9

  Hoogendoorn, Mechteld L C ^a   Bakker, Steven C ^a   Schnack, Hugo G ^a   Selten, Jean Paul C ^a   Otten, Henny G ^b   Verduijn, Willem ^c   Van Der Heijden, Frank M M A ^d   Pearson, Peter L ^b   Kahn, René S ^a   Sinke, Richard J ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d VINCENT VAN GOGH INSTITUTE FOR PSYCHIATRY   (Netherlands)

Author keywords

Association; DNA pooling; Dopaminergic transmission; Genetics; Schizophrenia

Indexed keywords

ARTICLE; COMT GENE; CONTROLLED STUDY; DAT1 GENE; DBH GENE; DDC GENE; DOPAMINERGIC TRANSMISSION; DRD1 GENE; DRD2 GENE; DRD3 GENE; DRD4 GENE; DRD5 GENE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC MARKER; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAOA GENE; MAOB GENE; MICROSATELLITE MARKER; NETHERLANDS; NEUROTRANSMISSION; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; TH GENE;

DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENETIC MARKERS; GENOTYPE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROSATELLITE REPEATS; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; NETHERLANDS; RECEPTORS, DOPAMINE; SCHIZOPHRENIA; TYROSINE 3-MONOOXYGENASE;

EID: 20144382742     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30147     Document Type: Article

References (15)

1. Andreasen NC, Flaum M, Amdt S. 1992. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiat 49:615-623.
2. Daniels J, Holmans P, Williams N, Turic D, McGuffin P, Plomin R, Owen MJ. 1998. A simple method for analyzing microsatellite allele image patterns generated from DNA pools and its application to allelic association studies. Am J Hum Genet 62:1189-1197.
3. Glatt SJ, Faraone SV, Tsuang MT. 2003. Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia. Mol Psychiatry 8:911-915.
4. Kendler SK, Maclean CJ, Yunlong M, O'Neill FA, Walsh D, Straub RE. 1999. Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees. Am J Med Genet (Neuropsychiatric Genet) 88:29-33.
5. Kirov G, Williams N, Sham P, Craddock N, Owen MJ. 2000. Pooled genotyping of microsatellite markers in parent-offspring trios. Genome Res 10:105-115.
6. Muir WJ, Thomson ML, McKeon P, Mynett-Johson L, Whitton C, Evans KL, Porteous DJ, Blackwood DH. 2001. Markers close to the dopamine D5 receptor gene (DBD5) show significant association with schizophrenia but not bipolar disorder. Am J Med Genet (Neuropsychiatr Genet) 105:152-158.
7. Owen MJ, Williams NM, O'Donovan MC. 2004. The molecular genetics of schizophrenia: New findings promise new insights. Mol Psychiatry 9:14-27.
8. Purcell S, Chemy SS, Sham PC. 2003. Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150.
9. Raymond M, Rousset F. 1995. GENEPOP (version 1.2): Population genetics software for exact test and ecumenicism. J Hered 86:248-249.
10. Schnack HG, Bakker SC, van't Slot R, Groot BM, Sinke RJ, Kahn RS, Pearson PS. 2004. Accurate determination of microsatellite allele frequencies in pooled DNA samples. Eur J Hum Gen 12:925-934.
11. Sham PC, Curtis D. 1995. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59(Pt 1): 97-105.
12. Sham P, Bader JS, Craigl, O'Donovan M, Owen M. 2002. DNA pooling: A tool for large scale association studies. Nat Rev Genet 3:862-871.
13. Sullivan PF, Kendler KS, Neale MC. 2003. Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies. Arch Gen Psychiat 60:1187-1192.
14. Varilo T, Paunio T, Parker A, Perola M, Meyer J, Terwilliger JD, Peltonen L. 2003. The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories. Hum Mol Genet 12: 51-59.
15. Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L, Cardno A, Asherson P, Blackwood D, Muir W, Meszaros K, Aschauer H, Mallet J, Laurent C, Pekkarinen P, Seppala J, Stefanis CN, Papadimitriou GN, Macciardi F, Verga M, Pato C, Azevedo H, Crocq MA, Gurling H, Owen MJ. 1998. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 3:141-149.