Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 1, 1999, Pages 29-33

  Kendler, Kenneth S ^a   MacLean, Charles J ^a   Ma, Yunlong ^a   O'Neill, F Anthony ^b   Walsh, Dermot ^c   Straub, Richard E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c HEALTH RESEARCH BOARD   (Ireland)

Author keywords

Association; Ireland; Linkage disequilibrium; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 5Q; CHROMOSOME 6P; CHROMOSOME 8P; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC SELECTION; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MOLECULAR CLONING; PEDIGREE; PRIORITY JOURNAL; SCHIZOPHRENIA;

CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 8; GENETIC MARKERS; HAPLOTYPES; HUMANS; IRELAND; LINKAGE DISEQUILIBRIUM; MICROSATELLITE REPEATS; MODELS, STATISTICAL; PEDIGREE; SCHIZOPHRENIA;

EID: 0033525152     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990205)88:1<29::AID-AJMG5>3.0.CO;2-7     Document Type: Article

References (31)

1. Banchs I, Bosch A, Guimera J, Lazaro C, Puig A, Estivill X. 1994. New alleles at microsattelite loci in CEPH families mainly arise from somatic mutations in the lymphoblastoid cell lines. Hum Mutat 3:365-372.
2. Castiglione CM, Deinard AS, Speed WC, Sirugo G, Rosenbaum HC, Zhang Y. Grandy DK, Grigorenko EL, Bonne-Tamir B, Pakstis AJ, Kidd JR, Kidd KK. 1995. Evolution of haplotypes at the DRD2 locus. Am J Hum Genet 57:1445-1456.
3. Chakraborty R, Kimmel M, Stivers DN, Davison LJ, Deka R. 1997. Relative mutation rates at di-, tri-, and tetranucleotide microsatellite loci. Proc Natl Acad Sci USA 94:1041-1046.
4. Conover WJ. 1980. Practical nonparametric statistics. 2nd ed. New York: John Wiley & Sons. p 178-189.
5. Devlin B, Risch N. 1995. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29:311-322.
6. Feild HS, Armenakis AA. 1974. On use of multiple tests of significance in psychological research. Psychol Rep 35:427-431.
7. Growe GA, Crayton JW, Klass DB, Evans H, Strizich M. 1979. Lithium in chronic schizophrenia. Am J Psychiatry 136:454-455.
8. Hastbacka J, de la Chapelle A, Kaitila I, Sistonen P, Weaver A, Lander E. 1992. Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland. Nat Genet 2:204-211.
9. Hill WG, Weir BS. 1988. Variances and covariances of squared linkage disequilibria in finite populations. Theor Popul Biol 33:54-78.
10. Hudson RR. 1985. The sampling distribution of linkage disequilibrium under an infinite allele model without selection. Genetics 109:611-631.
11. Jorde LB. 1995. Linkage disequilibrium as a gene-mapping tool. Am J Hum Genet 56:11-14.
12. Jorde LB, Watkins WS, Carlson M, Groden J, Albertsen H, Thliveris A, Leppert M. 1994. Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am J Hum Genet 54:884-898.
13. Kendler KS, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub RE. 1996a. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 153:1534-1540.
14. Kendler KS, O'Neill FA, Burke J, Murphy B, Duke F, Straub RE, Shinkwin R, Ni Nuallain M, MacLean CJ, Walsh D. 1996b. Irish Study of High-Density Schizophrenia Families: Field methods and power to detect linkage. Am J Med Genet (Neuropsychiatr Genet) 67:179-190.
15. Klitz W, Stephens JC, Grote M, Carrington M. 1995. Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region. Am J Hum Genet 57:1436-1444.
16. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58:1347-1363.
17. Laan M, Pääbo S. 1997. Demographic history and linkage disequilibrium in human populations. Nat Genet 17:435-438.
18. Lander ES, Green P. 1987. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 84:2363-2367.
19. Mahtani MM, Willard HF. 1993. A polymorphic X-linked tetranucleotide repeat locus displaying a high rate of new mutation: Implications for mechanisms of mutation at short tandem repeat loci. Hum Mol Genet 2:431-437.
20. Marron MP, Raffel LJ, Garchon H-J, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng W-P, Park Y, Zhang Z-X, Goldstein DR, Tao Y-W, Beaurain G, Bach J-F, Huang H-S, Luo D-F, Zeidler A, Rotter JI, Yang MCK, Modilevsky T, Maclaren NK, She J-X. 1997. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum Mol Genet 6:1275-1282.
21. Merriman TR, Eaves IA, Twells RCJ, Merriman ME, Danoy PAC, Muxworthy CE, Hunter KMD, Cox RD, Cucca F, McKinney PA, Shield JPH, Baum JD, Tuomilehto J, Tuomilehto-Wolf E, Tirgoviste CI, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Bain SC, Todd JA. 1998. Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6). Hum Mol Genet 7:517-524.
22. Peterson AC, Di Rienzo A, Lehesjoki AE, de la Chapelle A, Slatkin M, Freimer NB. 1995. The distribution of linkage disequilibrium over anonymous genome regions. Hum Mol Genet 4:887-894.
23. Relethford JH, Crawford MH. 1995. Anthropometric variation and the population history and genetic structure in Ireland. Am J Phys Anthropol 96:25-38.
24. Sherrington R, Melmer G, Dixon M, Curtis D, Mankoo B, Kalsi G, Gurling H. 1991. Linkage disequilibrium between two highly polymorphic microsatellites. Am J Hum Genet 49:966-971.
25. SigmaPlot 4.0 for Windows. 1997. Chicago, IL: SPSS, Inc.
26. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, Kendler KS. 1995. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity. Nat Genet 11:287-293.
27. Straub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler KS. 1997. Support for a possible schizophrenia vulnerability locus in region 5q21-q31 in Irish families. Mol Psychiatry 2:148-155.
28. Thompson EA, Neel JV. 1997. Allelic disequilibrium and allele frequency distribution as a function of social and demographic history. Am J Hum Genet 60:197-204.
29. Tishkoff SA, Dietzsch E, Speed WC, Pakstis AJ, Kidd JR, Cheung K, Bonne-Tamir B, Santachiara-Benerecetti AS, Moral P, Krings M. 1996. Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science 271:1380-1387.
30. Varilo T, Savukoski M, Norio R, Santavuori P, Peltonen L, Jarvela I. 1996. The age of human mutation: Genealogical and linkage disequilibrium analysis of the CLN5 mutation in the Finnish population. Am J Hum Genet 58:506-512.
31. Weber JL, Wong C. 1993. Mutation of human short tandem repeats. Hum Mol Genet 2:1123-1128.