Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria

Metabolic Engineering

Volumn 7, Issue 2, 2005, Pages 59-69

  Shirai, Tomokazu ^a   Nakato, Akinori ^a   Izutani, Noriyuki ^a   Nagahisa, Keisuke ^a   Shioya, Suteaki ^a   Kimura, Eiichiro ^b   Kawarabayasi, Yutaka ^c,d   Yamagishi, Akihiko ^e   Gojobori, Takashi ^f   Shimizu, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^e TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^f NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

Coryneform bacterium; Glutamate production; MFA

Indexed keywords

AMINO ACIDS; CELLS; ENZYMES; METABOLISM; REACTION KINETICS; TARGETS;

2-OXOGLUTAMATE DEHYDROGENASE COMPLEX (ODHC); BIOTIN; CORYNEFORM BACTERIAS; METABOLIC PATHWAYS;

BACTERIA;

2 OXOGLUTARIC ACID; BIOTIN; DETERGENT; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; ISOCITRATE DEHYDROGENASE; POLYSORBATE 40;

ACTINOMYCETALES; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ANALYTIC METHOD; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATION; CONTROLLED STUDY; CORYNEBACTERIUM EFFICIENS; CORYNEBACTERIUM GLUTAMICUM; ENZYME ACTIVITY; FERMENTATION; INTERMETHOD COMPARISON; KINETICS; MICHAELIS CONSTANT; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PARAMETER; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; SIMULATION; SPECIES COMPARISON; STATISTICAL SIGNIFICANCE;

BACTERIAL PROTEINS; CORYNEBACTERIUM GLUTAMICUM; GLUTAMIC ACID; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; OXIDOREDUCTASES;

BACTERIA (MICROORGANISMS); CORYNEBACTERIACEAE; CORYNEBACTERIUM EFFICIENS; CORYNEBACTERIUM GLUTAMICUM; CORYNEFORM BACTERIUM;

EID: 20144381890     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2004.10.001     Document Type: Article

References (19)

1. A.S. Anton, J.C. Helen, and J.R. Sharon Nitrogen and carbon regulation of glutamine synthetase and glutamate snthase in Corynebacterium glutamicum FEMS Microbiol. Lett. 205 2001 361 367
2. B.J. Eikmanns, D. Rittmann, and H. Sahm Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme J. Bacteriol. 177 1995 774 782
3. DDBJ, 2004. http://www.ddbj.nig.ac.jp.
4. A.L. Demain, and J. Birnbaum Alternation of permeability for the release of metabolites from the microbial cell Curr. Top. Microbiol. Immunol. 46 1968 1 25
5. H. Dominguez, C. Rollin, A. Guyonvarch, J.L. Guerquin-Kerm, M. Cocaign-Bousquet, and N.D. Lindley Carbon-flux distribution in the central metabolism pathways of Corynebacterium glutamicum during growth on fructose Eur. J. Biochem. 254 1 1998 96 102
6. R. Fudou, Y. Jojima, A. Seto, F. Yamada, E. Kimura, T. Nakamatsu, A. Hiroishi, and S. Yamanaka Corynebacterium efficiens sp. nov., a glutamic acid-producing species from soil and vegetables Int. J. Syst. Evol. Microbiol. 52 Part 4 2002 1127 1131
7. Y. Kawahara, K. Takahashi-Fuke, E. Shimizu, T. Nakamatsu, and S. Nakamori Relationship between the glutamate production and the activity of 2-oxoglutarate dehydrogenase in Brevibacterium lactofermentum Biosci. Biotechnol. Biochem. 61 7 1997 1109 1112
8. S. Kinoshita, S. Udaka, and M. Shimono Studies on the amino acid fermentation J Gen. Appl. Microbiol., Jpn. 3 1957 193 205
9. E. Kimura Triggering mechanism of L-glutamate overproduction by DtsRl in coryneform bacteria J. Biosci. Bioeng. 94 2002 545 551
10. A. Marx, A.A. de Graaf, W. Wiechert, L. Eggeling, and H. Sahm Determination of the fluxes in the central carbon metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing Biotechnol. Bioeng. 49 1996 111 129
11. A. Marx, B.J. Eikmanns, H. Sahm, A.A. de Graaf, and L. Eggeling Response of the central metabolism in Corynebacterium glutamicum to the use of a NADH-dependent glutamate Dehydrogenase Metab. Eng. 1 1999 35 48
12. Y. Nakao, M. Kikuchi, M. Suzuki, and M. Doi Microbial production of L-glutamic acid from n-paraffin by glycerol auxotrophs Agric. Biol. Chem. 34 1970 1875 1876
13. Y. Nishio, Y. Nakayama, Y. Kawarabayashi, Y. Usuda, E. Kimura, S. Sugimoto, K. Matsui, A. Yamagishi, H. Kikuchi, K. Ikeo, and T. Gojobori Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens Genome Res. 13 7 2003 1572 1579
14. J. Ohnishi, S. Mitsuhashi, M. Hayashi, S. Ando, H. Yokoi, K. Ochiai, and M. Ikeda A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant Appl. Microbiol. Biotechnol. 58 2 2002 217 223
15. C. Rollin, V. Morgant, A. Guyonvarch, and J.L. Guerquin-Kern 13C-NMR studies of Corynebacterium melassecola Eur. J. Biochem. 227 1995 488 493
16. I. Shiio, and H. Ozaki Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum J. Biochem. 68 1970 633 647
17. H. Shimizu, H. Tanaka, A. Nakato, K. Nagahisa, E. Kimura, and S. Shioya Effects of the changes in enzyme activities on metabolic flux redistribution around the 2-oxoglutarate branch in glutamate production by Corynebacterium glutamicum Bioprocess Biosyst. Eng. 25 2003 291 298
18. G. Stephanopoulos, A. Aristidou, and J. Nielsen Metabolic Engineering 1998 Academic Press San Diego, CA
19. 15N nuclear magnetic resonance Appl. Environ. Microbiol. March 1999 1099 1109