Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders

International Journal of Neuropsychopharmacology

Volumn 8, Issue 2, 2005, Pages 235-244

  Koido, Kati ^a   Kõks, Sulev ^a,b   Nikopensius, Tiit ^a   Maron, Eduard ^a   Altmäe, Signe ^a   Heinaste, Evelin ^a   Vabrit, Kristel ^a   Tammekivi, Veronika ^a   Hallast, Pille ^a   Kurg, Ants ^a   Shlik, Jakov ^a   Vasar, Veiko ^a   Metspalu, Andres ^a,c   Vasar, Eero ^a,b  

^a UNIVERSITY OF TARTU   (Estonia)

^b Visgenyx Ltd   (Estonia)

^c Asper Biotech Ltd   (Estonia)

Author keywords

Association; Bipolar disorder; Genetics; Haplotype analysis; Major depressive disorder; Single nucleotide polymorphism (SNP); WFS1; Wolframin

Indexed keywords

ADENINE; CYTOSINE; GUANINE; PROTEIN; THYMINE; UNCLASSIFIED DRUG; WOLFRAMIN;

ADOLESCENT; ADULT; AGED; ANXIETY DISORDER; ARRAYED PRIMER EXTENSION; ARTICLE; BIPOLAR DISORDER; COMORBIDITY; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MOOD DISORDER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WOLFRAM SYNDROME; WSF1 GENE;

ADULT; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MOOD DISORDERS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RISK;

EID: 20044376749     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145704004791     Document Type: Article

References (29)

1. Awata T, Inoue K, Kurihara S, Ohkubo T, Inoue I, Abe T, Takino H, Kanazawa Y, Katayama S (2000). Missense variations of the gene responsible for Wolfram syndrome (WFS1/wolframin) in Japanese: possible contribution of the Arg456His mutation to type 1 diabetes as a nonautoimmune genetic basis. Biochemical and Biophysical Research Communications 268, 612-616.
2. Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF, Shibasaki Y, St Clair DM, Porteous DJ, Muir WJ (1996). A locus for bipolar affective disorder on chromosome 4p. Nature Genetics 12, 427-430.
3. Crawford J, Zielinski MA, Fisher LJ, Sutherland GR, Goldney RD (2002). Is there a relationship between Wolfram syndrome carrier status and suicide? American Journal of Medical Genetics 114, 343-346.
4. Cryns K, Pfister M, Pennings RJ, Bom SJ, Flothmann K, Caethoven G, Kremer H, Schatteman I, Köln KA, Tóth T, Kupka S, Blin N, Nürnberg P, Thiele H, van de Heyning PH, Reardon W, Stephens D, Cremers CW, Smith RJ, Van Camp G (2002). Mutations in the WFS1 gene that cause low-frequency sensorineural hearing loss are small non-inactivating mutations. Human Genetics 110, 389-394.
5. Cryns K, Sivakumaran TA, van den Ouweland JM, Pennings RJ, Cremers CW, Flothmann K, Young TI, Smith RJ, Lesperance MM, Van Camp G (2003). Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease. Human Mutation 22, 275-287.
6. Evans KL, Lawson D, Meitinger T, Blackwood DH, Porteous DJ (2000). Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder. American Journal of Medical Genetics 96, 158-160.
7. Furlong RA, Ho LW, Rubinsztein JS, Michael A, Walsh C, Paykel ES, Rubinsztein DC (1999). A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases. Neuroscience Letters 277, 123-126.
8. Hardy C, Khanim F, Torres R, Scott-Brown M, Seller A, Poulton J, Collier D, Kirk J, Polymeropoulos M, Latif F, Barrett T (1999). Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1. American Journal of Human Genetics 65, 1279-1290.
9. Hofmann S, Philbrook C, Gerbitz KD, Bauer MF (2003). Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product. Human Molecular Genetics 12, 2003-2012.
10. Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi E, Mueckler M, Marshall H, Donis-Keller H, Crock P, Rogers D, Mikuni M, Kumashiro H, Higashi K, Sobue G, Oka Y, Permutt MA (1998). A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nature Genetics 20, 143-148.
11. Kato T, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N (2003). No association of mutations and mRNA expression of WFS1/ wolframin with bipolar disorder in humans. Neuroscience Letters 338, 21-24.
12. Kinsley BT, Swift M, Dumont RH, Swift RG (1995). Morbidity and mortality in the Wolfram syndrome. Diabetes Care 18, 1566-1570.
13. Kurg A, Tõnisson N, Georgiou I, Shumaker J, Tollett J, Metspalu A (2000). Arrayed primer extension: solid-phase four-color DNA resequencing and mutation detection technology. Genetic Testing 4, 1-7.
14. Li S, Goldberg JF, Sivakumaran TA, Kocsis JH, Lesperance MM, Burmeister M (2002). Association of suicidality in bipolar patients with the T102C polymorphism of the 5-HT receptor 2A gene and coding variants R611H of the Wolfram syndrome 1 gene. 52nd Annual Meeting of the American Society of Human Genetics, Baltimore, MD, 15-19 October, 2002.
15. Middle F, Jones I, McCandless F, Barrett T, Khanim F, Owen MJ, Lendon C, Craddock N (2000). Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene. American Journal of Medical Genetics 96, 154-157.
16. Minton JA, Hattersley AT, Owen K, McCarthy MI, Walker M, Latif F, Barrett T, Frayling TM (2002). Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 51, 1287-1290.
17. Muir WJ, Thomson ML, McKeon P, Mynett-Johnson L, Whitton C, Evans KL, Porteous DJ, Blackwood DH (2001). Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder. American Journal of Medical Genetics 105, 152-158.
18. Ohtsuki T, Ishiguro H, Yoshikawa T, Arinami T (2000). WFS1 gene mutation search in depressive patients: detection of five missense polymorphisms but no association with depression or bipolar affective disorder. Journal of Affective Disorders 58, 11-17.
19. Osman AA, Saito M, Makepeace C, Permutt MA, Schlesinger PH, Mueckler M (2003). Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium. Journal of Biological Chemistry 278, 52755-52762.
20. Raymond M, Rousset F (1995). GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. Journal of Heredity 86, 284-295.
21. Sequeira A, Kim C, Seguin M, Lesage A, Chawky N, Desautels A, Tousignant M, Vanier C, Lipp O, Benkelfat C, Rouleau G, Turecki G (2003). Wolfram syndrome and suicide: evidence for a role of WFS1 in suicidal and impulsive behavior. American Journal of Medical Genetics 119B, 108-113.
22. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998). The Mini-International Neuropsychiatric Interview (M.I.N.L): the development and validation of a structured diagnostic psychiatric interview for DSM-FV and ICD-10. Journal of Clinical Psychiatry 59, 22-33.
23. Strom TM, Hortnagel K, Hofmann S, Gekeler F, Scharfe C, Rabl W, Gerbitz KD, Meitinger T (1998). Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Human Molecular Genetics 7, 2021-2028.
24. Swift RG, Perkins DO, Chase CL, Sadler DB, Swift M (1991). Psychiatric disorders in 36 families with Wolfram syndrome. American Journal of Psychiatry 148, 775-779.
25. Swift RG, Polymeropoulos MH, Torres R, Swift M (1998). Predisposition of Wolfram syndrome heterozygotes to psychiatric illness. Molecular Psychiatry 3, 86-91.
26. Swift RG, Sadler DB, Swift M (1990). Psychiatric findings in Wolfram syndrome homozygotes. Lancet 336, 667-669.
27. Torres R, Leroy E, Hu X, Katrivanou A, Gourzis P, Papachatzopoulou A, Athanassiadou A, Beratis S, Collier D, Polymeropoulos MH (2001). Mutation screening of the Wolfram syndrome gene in psychiatric patients. Molecular Psychiatry 6, 39-43.
28. Tregouet DA, Barbaux S, Escolano S, Tahri N, Golmard JL, Tiret L, Cambien F (2002). Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Human Molecular Genetics 11, 2015-2023.
29. Wei J, Hemmings GP (1999). The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. European Psychiatry 14, 67-70.