Predisposition of Wolfram syndrome heterozygotes to psychiatric illness

Molecular Psychiatry

Volumn 3, Issue 1, 1998, Pages 86-91

  Swift, R G ^a   Polymeropoulos, M H ^c   Torres, R ^c   Swift, M ^b  

^a Department of Psychiatry ^*  (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Heterozygotes; Psychiatric illness; Wolfram syndrome

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC PREDISPOSITION; HAPLOTYPE; HETEROZYGOTE; HUMAN; HUMAN CELL; INHERITANCE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PRIORITY JOURNAL; WOLFRAM SYNDROME;

EID: 0031983913     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000344     Document Type: Article

References (20)

1. Swift RG, Sadler DB, Swift M. Psychiatric findings in Wolfram syndrome homozygotes. Lancet 1990; 336: 667-669.
2. Swift M, Kupper LL, Chase CL. Effective testing of gene-disease associations. Am J Hum Genet 1990; 47: 266-274.
3. Michels R, Marzuk PM. Progress in psychiatry. N Engl J Med 1993; 329: 552-560.
4. Dahlberg G. Mathematical Methods for Human Population Genetics. Interscience Publishers: New York, 1948.
5. Athma P, Rappaport R, Swift M. Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer. Cancer Genetics and Cytogenetics 1996; 92: 130-134.
6. Schroeder SA, Gaughan DM, Swift M. Protection against bronchial asthma by CFTR ΔF508 mutation: a heterozygote advantage in cystic fibrosis. Nature Med 1995; 1: 703-705.
7. Wolfram DJ. Diabetes mellitus and simple optic atrophy among siblings: report of four cases. Staff Proc Mayo Clin 1938; 13: 715-718.
8. Kinsley BT, Swift M, Dumont RH, Swift RG. Morbidity and mortality in the Wolfram syndrome. Diabetes Care 1995; 18: 1566-1570.
9. Bretz GW, Baghdassarian A, Graber JD, Zacherle BJ, Norum RA, Blizzard JD. Coexistence of diabetes mellitus and insipidus and optic atrophy in two male siblings. Am J Med 1970; 48: 398-403.
10. Gossain VV, Sugawara M, Hagan GA. Co-existent diabetes mellitus and diabetes insipidus, a familial disease. J Clin Endocrinol Metab 1975; 41: 1020-1024.
11. Rose FC, Fraser GR, Friedmann AI, Kohner EM. The association of juvenile diabetes mellitus and optic atrophy: clinical and genetical aspects. Q J Med 1966; 35: 385-405.
12. Tunbridge RE, Paley RG. Primary optic atrophy in diabetes mellitus. Diabetes 1956; 5: 295-296.
13. Gregorios JB. Wolfram's syndrome with schizophrenia and central hypoventilation: a neuropathological study. J Neuropathol Exp Neurol 1389; 48: 308.
14. Nanko S, Yokoyama H, Hoshino Y, Kumashiro H, Mikuni M. Organic mood syndrome in two siblings with Wolfram syndrome [letter]. Br J Psychiatry 1992; 161: 282.
15. Kellner M, Strian F, Fassbender K, Kennerknecht I, Klein R. DIDMOAD (Wolfram) syndrome [letter]. Br J Psychiatry 1994; 164: 132.
16. Kinsley BT, Firth RGR. The Wolfram syndrome: a primary neurodegenerative disorder with lethal potential. Irish Med J 1992; 85: 34-36.
17. Swift RG, Perkins DO, Chase CL, Sadler DB, Swift M. Psychiatric disorders in 36 Wolfram syndrome families. Am J Psychiatry 1991; 148: 775-779.
18. Polymeropoulos MH, Swift RG, Swift M. Linkage of the Wolfram syndrome disease gene with markers on the short arm of chromosome 4. Nature Genet 1994; 8: 95-97.
19. Nelson PV, Carey WF, Morris CP, Pollard AC. Cystic fibrosis: prenatal diagnosis and carrier detection by DNA analysis. Med J Aust 1989; 151: 126-127, 130-131.
20. Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ et al. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 1989; 342: 238-243.