A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases

Neuroscience Letters

Volumn 277, Issue 2, 1999, Pages 123-126

  Furlong, Robert A ^a,b   Ho, Luk W ^b   Rubinsztein, Judy S ^b   Michael, Albert ^c   Walsh, Cathy ^b   Paykel, Eugene S ^b   Rubinsztein, David C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c WEST SUFFOLK HOSPITAL   (United Kingdom)

Author keywords

Bipolar affective disorder; Unipolar affective disorder; Wolframin

Indexed keywords

RESTRICTION ENDONUCLEASE;

ALLELE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE CARRIER; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIC DEPRESSIVE PSYCHOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SUICIDE ATTEMPT; WOLFRAM SYNDROME;

ALLELES; BIPOLAR DISORDER; CODON; DEPRESSIVE DISORDER; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; MEMBRANE PROTEINS; MOOD DISORDERS; POLYMORPHISM, GENETIC; WOLFRAM SYNDROME;

EID: 0032712022     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00865-4     Document Type: Article

References (15)

1. Barrett T.G., Bundey S.E., Macleod A.F. Neurodegeneration and diabetes: UK nationwide study of DIDMOAD (Wolfram) syndrome. Lancet. 346:1995;1458-1463.
2. Blackwood D.H.R., Lin H., Morris S.W., McLean A., Whitton C., Thomson M., Walker M.T., Woodburn K., Sharp C.M., Wright A.F., Shibasaki Y., St Clair D.M., Porteous D.J., Muir W.J. A locus for bipolar affective disorder on chromosome 4p. Nat. Genet. 12:1996;427-430.
3. Breslow N.E., Day N.E. 'Statistical Methods in Core Research Vol. I: The Design and Analysis of Case-control Studies'. No. 32 :1980;IARC Scientific Publications, IARC Lyon.
4. Cserzo M., Wallin E., Simon G., von Heijne G., Elofsson A. Prediction of transmembrane α -helices in prokariotic membrane proteins: the dense alignment surface method. Proc. Eng. 10:1997;673-676.
5. Endicott J., Spitzer R.L. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch. Gen. Psychiatry. 35:1978;837-862.
6. Gershon E.S. Genetics. Goodwin F.K., Jamieson K.R. 'Manic-Depressive Illness,'. 1990;373-401 Oxford University Press, Oxford.
7. Hofmann K., Stoffel W. Tmbase - a database of membrane spanning protein segments. Biol. Chem. Hoppe-Seyler. 374:1993;166.
8. Inoue H., Tanizawa Y., Wasson J., Behn P., Kalidas K., Bernal-Mizrachi E., Mueckler M., Marshall H., Donis-Keller H., Crock P., Rogers D., Mikuni M., Kumashiro H., Higashi K., Sobue G., Oka Y., Permutt M.A.,. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nature Genet. 20:1998;143-148.
9. McGuffin P., Katz R. The genetics of depression and manic-depressive disorder. Br. J. Psychiatry. 155:1989;294-304.
10. Polymeropoulos M.H., Lavendan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the α synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
11. Spitzer R.L., Endicott J., Robins E. Research diagnostic criteria: rationale and reliability. Arch. Gen. Psychiatry. 35:1978;773-782.
12. Strom T.M., Hortnagel K., Hofmann S., Gekeler F., Scharfe C., Rabi W., Gerbitz K.D., Meitinger T. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein, Human Mol. Genet. 7:1998;2021-2028.
13. Swift R.G., Perkins D.O., Chase C.L., Sadler D.B., Swift M. Psychiatric disorders in 36 families with Wolfram syndrome. Am. J. Psychiatry. 148:1991;775-779.
14. Swift R.G., Polymeropoulos M.H., Torres R., Swift M. Predisposition of Wolfram syndrome heterozygotes to psychiatric illness. Mol. Psychiatry. 3:1998;86-91.
15. Swift R.G., Sadler D.B., Swift M. Psychiatric findings in Wolfram syndrome homozygotes. Lancet. 336:1990;667-669.