[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 371, Issue 3, 2005, Pages 169-177

  Wainscott, David B ^a   Krushinski Jr , Joseph H ^a   Audia, James E ^a   Schaus, John M ^a   Zgombick, John M ^b   Lucaites, Virginia L ^a   Nelson, David L ^a  

^a ELI LILLY AND COMPANY   (United States)

^b H LUNDBECK A S   (Denmark)

Author keywords

5 HT1F; LY334370; Migraine

Indexed keywords

3 DIMETHYLAMINO 2,3,4,9 TETRAHYDRO 1H CARBAZOL 6 OL; 5 (4 FLUOROBENZAMIDO) 3 (1 METHYL 4 PIPERIDINYL) 1H INDOLE FUMARATE; 5 FLUORO 3 [1 [2 (2 METHYL 1H PYRAZOL 4 YL)ETHYL] 4 PIPERIDINYL] 1H INDOLE; 5 METHYLAMINOSULFONYLMETHYL 3 (1 METHYL 2 PYRROLIDINYLMETHYL) 1H INDOLE; CARBAZOLE DERIVATIVE; DIHYDROERGOTAMINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LY 302148; LY 306258; MAGNESIUM CHLORIDE; METHYSERGIDE; N [4 [5 [3 (2 AMINOETHYL) 1H INDOL 5 YL] 1,2,4 OXADIAZOL 3 YL]BENZYL]METHANESULFONAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NARATRIPTAN; PIPERIDINE DERIVATIVE; RADIOLIGAND; RIZATRIPTAN; SEROTONIN; SEROTONIN 1F RECEPTOR; SULFUR 35; SUMATRIPTAN; TRITIUM; UNCLASSIFIED DRUG; ZOLMITRIPTAN; 4 FLUORO N (3 (1 METHYL 4 PIPERIDINYL) 1H INDOL 5 YL)BENZAMIDE; 4-FLUORO-N-(3-(1-METHYL-4-PIPERIDINYL)-1H-INDOL-5-YL)BENZAMIDE; BENZAMIDE DERIVATIVE; INDOLE DERIVATIVE; LIGAND; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CELL TRANSFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG RECEPTOR BINDING; GUINEA PIG; MOLECULAR CLONING; NERVE STIMULATION; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; STATISTICAL SIGNIFICANCE; TRIGEMINAL NERVE; ANIMAL; CELL CULTURE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; RADIOASSAY;

ANIMALS; BENZAMIDES; BRAIN; CELLS, CULTURED; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; HUMANS; INDOLES; LIGANDS; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; TRANSFECTION; TRITIUM;

EID: 20044363625     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-005-1035-9     Document Type: Article

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