Chimerism in organ transplantation: Conflicting experiments and clinical observations

Transplantation

Volumn 75, Issue 9 SUPPL., 2003, Pages

  Monaco, Anthony P ^a   Medawar, Peter ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; FAS LIGAND; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAPAMYCIN;

ANIMAL MODEL; ANTIGEN EXPRESSION; BONE MARROW PURGING; BONE MARROW TRANSPLANTATION; CELL TRANSPLANTATION; CHIMERA; CLINICAL MEDICINE; CONFERENCE PAPER; DENDRITIC CELL; DRUG WITHDRAWAL; EXPERIMENTAL MEDICINE; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; IMMUNOLOGICAL TOLERANCE; IRRADIATION; MICROCHIMERISM; NONHUMAN; OBSERVATION; ORGAN TRANSPLANTATION; PRIORITY JOURNAL;

EID: 0037955550     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000067945.90241.f4     Document Type: Conference Paper

References (25)

1. Owen RD. Immunogenic consequences of vascular anastomoses between bovine twins. Science 1945; 102: 400.
2. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1955; 172: 603.
3. Billingham RE, Lampkin GH, Medawar PB, et al. Tolerance to homografts, twin diagnoses, and freemarten condition in cattle. Heredity 1952; 6: 201.
4. Sayegh MH, Fine NA, Smith JL, et al. Immunologic tolerance to renal allografts after bone marrow transplantation from the same donor. Ann Intern Med 1991; 114: 954.
5. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole organ transplantation: The basis of graft acceptance. Hepatology 1993; 17: 1127.
6. Gottlieb M, Strober S, Hoppe RT, et al. Engraftment of allogeneic bone marrow without graft versus host disease in mongrel dogs using total lymphoid irradiation. Transplantation 1980; 29: 487.
7. Koretz SH. Organ transplantation in mongrel dogs using total lymphoid irradiation. Transplant Proc 1981; 134: 443.
8. Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59: 256.
9. Kimikawa M, Sachs DH, Colvin RB, et al. Modification of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys. Transplantation 1997; 64: 709.
10. Kawai T, Poncelet A, Sachs DH, et al. Long term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance. Transplantation 1999; 68: 1767.
11. Spitzer TR, McAfee S, Sackstein R, et al. Combined histocompatibility leucocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end-stage renal disease: The induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999; 68: 480.
12. Caillat-Zucman S, Legendre C, Suberbielle C, et al. Microchimerism frequency two to thirty years after cadaveric kidney transplantation. Hum Immunol 1994; 41: 91.
13. Hisanaga M, Hundrieser J, Boker K, et al. Development, stability and clinical correlations of allogeneic microchimerism after solid organ transplantation. Transplantation 1996; 61: 40.
14. Devlin J, Doherty D, Thomson L, et al. Defining the outcome of immunosuppression withdrawal after liver transplantation. Hepatology 1998; 27: 94.
15. Schlitt HJ, Hundrieser J, Burckhardt R, et al. Donor type microchimerism associated with graft rejection eight years after liver transplantation. N Engl J Med 1994; 330: 646.
16. Ciancio G, Miller J, Garcia-Morales RO, et al. Six-year clinical effect of donor bone marrow infusions in renal transplant patients. Transplantation 2001; 71: 827.
17. Gozzo JJ, Wood ML, Monaco AP. Use of allogeneic, homozygous bone marrow cells for induction of specific immunologic tolerance in mice treated with antilymphocyte serum. Surg Forum 1970; 16: 171.
18. Monaco AP, Wood ML. Studies on heterologous antilymphocyte serum in mice: VII. Optimal cellular antigen for induction of immunological tolerance with antilymphocyte serum. Transplant Proc 1970; 2: 489.
19. Hale DA, Gottschalk R, Fukuzaki T, et al. Superiority of sirolimus (rapamycin) over cyclosporine in augmenting allograft and xenograft survival in mice treated with antilymphocyte serum and donor specific bone marrow. Transplantation 1997; 63: 359.
20. Hale DA, Gottschalk R, Maki T, et al. Determination of an improved sirolimus (rapamycin)-based regimen for induction of allograft tolerance in mice treated with antilymphocyte serum and donor specific bone marrow. Transplantation 1998; 65: 473.
21. Hale DA, Gottschalk R, Umemura A, et al. Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation: A unique role for sirolimus. Transplantation 2000; 69: 1242.
22. Tomita Y, Sachs DH, Khan A, et al. Additional monoclonal (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving anti-T cell MABs and 3-Gy whole body irradiation. Transplantation 1996; 61: 469.
23. Umemura A, Monaco AP, Maki T. Donor T cells are not required for induction of allograft tolerance in mice treated with antilymphocyte serum, rapamycin and donor bone marrow cells. Transplantation 2000; 70: 1005.
24. Umemura A, Monaco AP, Maki T. Donor MHC class II antigen is essential for induction of transplantation tolerance by bone marrow cells. J Immunol 2000; 164: 4452.
25. Umemura A, Morita H, Li XC, et al. Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J Immunol 2001; 167(6): 3043.