Detection of native peptides as potent inhibitors of enzymes: Crystal structure of the complex formed between treated bovine α-chymotrypsin and an autocatalytically produced fragment, Ile-Val-Asn-Gly-Glu-Glu-Ala-Val-Pro-Gly- Ser-Trp-Pro-Trp, at 2.2 Å resolution

FEBS Journal

Volumn 272, Issue 2, 2005, Pages 562-572

  Singh, Nagendra ^a   Jabeen, Talat ^a   Sharma, Sujata ^a   Roy, Ipsita ^b   Gupta, Munishwar N ^b   Bilgrami, Sameeta ^a   Somvanshi, Rishi K ^a   Dey, Sharmistha ^a   Perbandt, Marcus ^c   Betzel, Christian ^c   Srinivasan, A ^a   Singh, Tej P ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Autodigestion; Complex; Crystal structure; Inhibition; Peptide inhibitor

Indexed keywords

ACETIC ACID; CHYMOTRYPSIN; CHYMOTRYPSIN A; ISOLEUCINE; ISOLEUCYLVALYLASPARAGINYLGLYCYLGLUTAMYLALANYLVALYLPROLYLGLYCYLSERYLTRYPTOPH YLPROLYLTRYPTOPHANAMIDE; LYOPHILIZED PROTEIN; PEPTIDE; PROTEIN; SERINE PROTEINASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPETITIVE INHIBITION; COMPLEX FORMATION; COVALENT BOND; COW; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFUSION; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; OPTICAL RESOLUTION; PARTITION CHROMATOGRAPHY; PEPTIDE ANALYSIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN INTERACTION; REACTION ANALYSIS; THREE PHASE PARTITIONING SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CATTLE; CHYMOTRYPSIN; CRYSTALLIZATION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN FOLDING; SERINE PROTEINASE INHIBITORS;

BOVINAE;

EID: 19944433270     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2004.04499.x     Document Type: Article

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