A Novel Approach to the Design of Inhibitors of Human Secreted Phospholipase A2 Based on Native Peptide Inhibition

Journal of Biological Chemistry

Volumn 276, Issue 35, 2001, Pages 33156-33164

  Church, W Bret ^a   Inglis, Adam S ^a   Tseng, Albert ^a,c   Duell, Ray ^a   Lei, Pei Wen ^a   Bryant, Katherine J ^a,b   Scott, Kieran F ^a,b,d  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c Analytica Therapeutics Inc   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOLOGICAL MEMBRANES; CONFORMATIONS; ENZYMES; ESCHERICHIA COLI; SURFACE PLASMON RESONANCE;

MOLECULAR DOCKING;

BIOCHEMISTRY;

CYTOKINE; PENTAPEPTIDE; PEPTIDE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; CYCLOPEPTIDE; ENZYME INHIBITOR; GROUP II SECRETORY PHOSPHOLIPASE A2; OLIGOPEPTIDE; PEPTIDE FRAGMENT; PHOSPHOLIPASE A; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN CONFORMATION; PROTEIN FAMILY; STEADY STATE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; GENETIC TRANSFECTION; HAMSTER; KINETICS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PHOSPHOLIPASES A; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035980093     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101272200     Document Type: Article

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