Molecular interaction of the antagonist N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)- 4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1447-1459

  Shim, Joong Youn ^a   Welsh, William J ^b,c   Cartier, Etienne ^d,e   Edwards, James L ^d,f   Howlett, Allyn C ^d,g  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f University of Florida ^*  (United States)

^g NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (1,1 DIMETHYLHEPTYL) 2 (3 HYDROXY 7 HYDROXYMETHYLDECAHYDRO 1 NAPHTHYL)PHENOL; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; PYRAZOLE DERIVATIVE; RIMONABANT;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CHEMICAL ANALYSIS; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTROCHEMISTRY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR STABILITY; NONHUMAN; PHARMACOPHORE; PREDICTION; PROTON TRANSPORT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STRUCTURE ANALYSIS; VALIDATION PROCESS;

ALGORITHMS; ANIMALS; BRAIN; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; NAPHTHALENES; PIPERIDINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTONS; PYRAZOLES; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037187367     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010267o     Document Type: Article

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