Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression

Clinical Immunology

Volumn 114, Issue 2, 2005, Pages 199-209

  Azhipa, Olga ^a   Kimizuka, Kei ^a   Nakao, Atsunori ^a   Toyokawa, Hideyoshi ^a   Okuda, Toyokazu ^a   Neto, Joao Seda ^a   Alber, Sean M ^a   Kaizu, Takashi ^a   Thomson, Angus W ^a   Demetris, Anthony J ^a   Murase, Noriko ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

B cells; Donor dendritic cells; Tacrolimus

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL FATE; CELL MIGRATION; CELL TRANSPLANTATION; CELLULAR IMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DONOR; EX VIVO STUDY; GRAFT SURVIVAL; HOST CELL; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECIPIENT; T LYMPHOCYTE ACTIVATION;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FLOW CYTOMETRY; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE TOLERANCE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; LYMPHOCYTE CULTURE TEST, MIXED; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; SPECIFIC PATHOGEN-FREE ORGANISMS; TACROLIMUS;

EID: 19944426101     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2004.10.005     Document Type: Article

References (35)

1. R.I. Lechler, and J.R. Batchelor Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells J. Exp. Med. 155 1982 31 41
2. C.P. Larsen, P.J. Morris, and J.M. Austyn Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection J. Exp. Med. 171 1990 307 314
3. J. Sun, G.W. McCaughan, N.D. Gallagher, A.G. Sheil, and G.A. Bishop Deletion of spontaneous rat liver allograft acceptance by donor irradiation Transplantation 60 1995 233 236
4. R. Josien, M. Heslan, S. Brouard, J.P. Soulillou, and M.C. Cuturi Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion Blood 92 1998 4539 4544
5. S. Ko, A. Deiwick, M.D. Jager, A. Dinkel, F. Rohde, R. Fischer, T.Y. Tsui, K.L. Rittmann, K. Wonigeit, and H.J. Schlitt The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat Nat. Med. 5 1999 1292 1297
6. T.E. Starzl, A.J. Demetris, N. Murase, M. Trucco, A.W. Thomson, and A.S. Rao The lost chord: microchimerism and allograft survival Immunol. Today 17 1996 577 584 (discussion 588)
7. A. Sharland, Y. Yan, C. Wang, D.G. Bowen, J. Sun, A.G. Sheil, G.W. McCaughan, and G.A. Bishop Evidence that apoptosis of activated T cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations which break tolerance Transplantation 68 1999 1736 1745
8. S. Qian, L. Lu, F. Fu, Y. Li, W. Li, T.E. Starzl, J.J. Fung, and A.W. Thomson Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction J. Immunol. 158 1997 4654 4661
9. F. Fu, Y. Li, S. Qian, L. Lu, F. Chambers, T.E. Starzl, J.J. Fung, and A.W. Thomson Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients Transplantation 62 1996 659 665
10. H. Jonuleit, E. Schmitt, G. Schuler, J. Knop, and A.H. Enk Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells J. Exp. Med. 192 2000 1213 1222
11. N. Murase, T.E. Starzl, M. Tanabe, S. Fujisaki, H. Miyazawa, Q. Ye, C. Delaney, J.J. Fung, and A.J. Demetris Variable chimerism, graft versus host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats Transplantation 60 1995 158 171
12. N. Ichikawa, A.J. Demetris, T.E. Starzl, Q. Ye, T. Okuda, H.J. Chun, K. Liu, Y.M. Kim, and N. Murase Donor and recipient leukocytes in organ allografts of recipients with variable donor-specific tolerance: with particular reference to chronic rejection Liver Transplant. 6 2000 686 702
13. T. Okuda, T. Ishikawa, O. Azhipa, N. Ichikawa, A.J. Demetris, T.E. Starzl, and N. Murase Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells Transplantation 74 2002 103 111
14. M. Talmor, A. Mirza, S. Turley, I. Mellman, L.A. Hoffman, and R.M. Steinman Generation or large numbers of immature and mature dendritic cells from rat bone marrow cultures Eur. J. Immunol. 28 1998 811 817
15. M. Chen-Woan, C.P. Delaney, V. Fournier, Y. Wakizaka, N. Murase, J. Fung, T.E. Starzl, and A.J. Demetris A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF, and their quantification using the mAb OX-62 J. Immunol. Methods 178 1995 157 171
16. A. Sanchez-Fueyo, M. Weber, C. Domenig, T.B. Strom, and X.X. Zheng Tracking the immunoregulatory mechanisms active during allograft tolerance J. Immunol. 168 2002 2274 2281
17. E.J. Suchin, P.B. Langmuir, E. Palmer, M.H. Sayegh, A.D. Wells, and L.A. Turka Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question J. Immunol. 166 2001 973 981
18. T.R. Jones, J. Ha, M.A. Williams, A.B. Adams, M.M. Durham, P.A. Rees, S.R. Cowan, T.C. Pearson, and C.P. Larsen The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts J. Immunol. 168 2002 1123 1130
19. L. Liu, M. Zhang, C. Jenkins, and G.G. MacPherson Dendritic cell heterogeneity in vivo: two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression J. Immunol. 161 1998 1146 1155
20. J.M. Austyn, J.W. Kupiec-Weglinski, D.F. Hankins, and P.J. Morris Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone J. Exp. Med. 167 1988 646 651
21. P. Garside, E. Ingulli, R.R. Merica, J.G. Johnson, R.J. Noelle, and M.K. Jenkins Visualization of specific B and T lymphocyte interactions in the lymph node Science 281 1998 96 99
22. E. Ingulli, D.R. Ulman, M.M. Lucido, and M.K. Jenkins In situ analysis reveals physical interactions between CD11b+ dendritic cells and antigen-specific CD4 T cells after subcutaneous injection of antigen J. Immunol. 169 2002 2247 2252
23. K. Inaba, S. Turley, F. Yamaide, T. Iyoda, K. Mahnke, M. Inaba, M. Pack, M. Subklewe, B. Sauter, D. Sheff, M. Albert, N. Bhardwaj, I. Mellman, and R.M. Steinman Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells J. Exp. Med. 188 1998 2163 2173
24. C. Reis e Sousa, and R.N. Germain Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue J. Immunol. 162 1999 6552 6561
25. T.E. Starzl, A.J. Demetris, M. Trucco, N. Murase, C. Ricordi, S. Ildstad, H. Ramos, S. Todo, A. Tzakis, and J.J. Fung Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance [see comments] Hepatology 17 1993 1127 1152
26. A.J. Demetris, N. Murase, and T.E. Starzl Donor dendritic cells in grafts and host lymphoid and non-lymphoid tissues after liver and heart allotransplantation under short-term immunosuppression Lancet 339 1992 1610
27. A.E. Morelli, M.A. Antonysamy, T. Takayama, H. Hackstein, Z. Chen, S. Qian, N.B. Zurowski, and A.W. Thomson Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus J. Immunol. 165 2000 226 237
28. A. Nopora, and T. Brocker Bcl-2 controls dendritic cell longevity in vivo J. Immunol. 169 2002 3006 3014
29. B.R. Wong, R. Josien, S.Y. Lee, B. Sauter, H.L. Li, R.M. Steinman, and Y. Choi TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor J. Exp. Med. 186 1997 2075 2080
30. W.R. Heath, and F.R. Carbone Cross-presentation, dendritic cells, tolerance and immunity Annu. Rev. Immunol. 19 2001 47 64
31. E.J. Fuchs, and P. Matzinger B cells turn off virgin but not memory T cells Science 258 1992 1156 1159
32. M. Niimi, D.L. Roelen, W. Wong, M. Hara, P.J. Morris, and K.J. Wood Resting B cells as tolerogens in vivo but only for minor histocompatibility antigens: evidence for activation of resting B cells in vivo Transplantation 64 1997 1330 1335
33. G. Szabo, C. Gavala, and P. Mandrekar Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells J. Investig. Med. 49 2001 442 449
34. N.C. Chowdhury, B. Murphy, M.H. Sayegh, M.X. Jin, D.K. Roy, M.A. Hardy, and S.F. Oluwole Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides Transplantation 62 1996 1878 1882
35. A. Ali, M. Garrovillo, M.X. Jin, M.A. Hardy, and S.F. Oluwole Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells Transplantation 69 2000 221 226