Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 12, 2005, Pages 3024-3028

  Chouteau, Franck ^a   Ramanitrahasimbola, David ^b   Rasoanaivo, Philippe ^b   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b INSTITUT MALGACHE DE RECHERCHES APPLIQUÉES   (Madagascar)

Author keywords

Chemosensitizers; Chloroquine; Malaria

Indexed keywords

BICYCLO COMPOUND; BROMINE DERIVATIVE;

ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; SUBSTITUTION REACTION;

ANIMALS; ANTIMALARIALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CHLOROQUINE; DRUG RESISTANCE; DRUG RESISTANCE, MULTIPLE; HUMANS; HYDROCARBONS, BROMINATED; MALARIA; PHENOTHIAZINES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHENES;

PLASMODIUM FALCIPARUM;

EID: 19944384572     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.04.033     Document Type: Article

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