Transgenic introduction of human galactosylceramidase into twitcher mouse: Significant phenotype improvement with a minimal expression

Developmental Brain Dysfunction

Volumn 10, Issue 3, 1997, Pages 142-154

  Matsumoto, Akiko ^a   Vanier, Marie T ^d   Oya, Yasushi ^a   Kelly, Donna ^a   Popko, Brian ^a,b   Wenger, David A ^c   Suzuki, Kinuko ^a   Suzuki, Kunihiko ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Dept of Biochemistry and Biophysics ^*  (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d INSERM   (France)

Author keywords

Animal model; Galactosylceramidase; Gene therapy; Globoid cell leukodystrophy; Psychosine; Transgenic treatment; Twitcher

Indexed keywords

GALACTOSYLCERAMIDASE; MYELIN BASIC PROTEIN; PSYCHOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GLOBOID CELL LEUKODYSTROPHY; HUMAN; KIDNEY; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; SURVIVAL; TRANSGENE; TRANSGENIC MOUSE; WEIGHT GAIN;

EID: 0031400601     PISSN: 10195815     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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