SEA-0400, a potent inhibitor of the Na+/Ca2+ exchanger, as a tool to study exchanger ionic and metabolic regulation

American Journal of Physiology - Cell Physiology

Volumn 288, Issue 6 57-6, 2005, Pages

  Beaugé, Luis ^a   DiPolo, Reinaldo ^b,c  

^a INSTITUTO DE INVESTIGACIÓN MÉDICA MERCEDES Y MARTÍN FERREYRA   (Argentina)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^c MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

Ionic metabolic interactions

Indexed keywords

2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; 2 [4 [(2,5 DIFLUOROPHENYL)METHOXY]PHENOXY 5 ETHOXYANILINE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; ENZYME INHIBITOR; PROTON; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; DIPHENYL ETHER DERIVATIVE;

ACIDIFICATION; ALKALINIZATION; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; ION EXCHANGE; METABOLIC REGULATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE; SODIUM TRANSPORT; STEADY STATE; ANIMAL; CEPHALOPOD; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; NERVE CELL; PHYSIOLOGY;

CEPHALOPODA;

ADENOSINE TRIPHOSPHATE; ANILINE COMPOUNDS; ANIMALS; DECAPODIFORMES; NEURONS; PHENYL ETHERS; SODIUM-CALCIUM EXCHANGER;

EID: 19644395146     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00492.2004     Document Type: Article

References (26)

1. 2+ uptake in plasma membrane vesicles from squid optic nerve. Ann NY Acad Sci 779: 208-216, 1996.
2. Blaustein MP and Lederer WJ, Sodium/calcium exchange: its physiological implications. Physiol Rev 79: 763-854, 1999.
3. 2+ exchangers with altered ionic regulation. Mol Pharmacol 65: 802-810, 2004.
4. DiPolo R, Berberián G, Delgado D, Rojas H, and Beaugé L. A novel 13 kDa cytoplasmic soluble protein is required for the nucleotide (MgATP) modulation of the Na/Ca exchange in squid nerve fibers. FEBS Lett 401: 6-10, 1997.
5. DiPolo R and Beaugé L. Metabolic regulation of the Na/Ca exchange, the role of phosphorylation and dephosphorylation. Biochim Biophys Acta 1422; 57-71, 1999.
6. DiPolo R and Beaugé L. MgATP counteracts intracellular proton inhibition of the sodium-calcium exchanger in dialysed squid axons. J Physiol 539: 791-803, 2002.
7. 2+ exchanger: metabolic pathway and exchanger-ligand interactions different from those seen with ATP. J Physiol 554: 387-401, 2003.
8. 2+ exchanger in the guinea-pig. J Physiol 480: 9-20, 1994.
9. Hilgemann DW, Collins A, and Matsuoka S. Steady-state and dynamic properties of cardiac sodium-calcium exchange: secondary modulation by cytoplasmic calcium and ATP. J Gen Physiol 100: 933-961, 1992.
10. Hilgemann DW, Matsuoka S, Nagel GA, and Collins A. Steady-state and dynamic properties of cardiac sodium-calcium exchange: sodium-dependent inactivation. J Gen Physiol 100: 905-932, 1992.
11. Hilgemann DW. Cytoplasmic ATP-dependent regulation of ion transporters and channels: mechanisms and messengers. Annu Rev Physiol 59: 193-220, 1997.
12. 2+ exchange in cells expressing NCX1. J Biol Chem 271: 22391-22397, 1996.
13. 2+ exchanger. Mol Pharmacol 59: 524-531, 2001.
14. 2+ exchange (NCX1) inhibition by SEA0400. J Biol Chem 279: 7544-7553, 2004.
15. 2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl] thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol Pharmacol 66: 45-55, 2004.
16. Jencks WP and Regenstein T. Ionization constants of acids and bases. In: CRC Handbook of Biochemistry and Molecular Biology (3rd ed.), edited by Fasman GD. Boca Raton, FL: CRC, 1977, vol. 1, p. 327-328.
17. 2+ exchanger, NCX1.1. J Pharmacol Exp Ther 311: 748-757, 2004.
18. 2+ exchanger inhibitors SEA0400 and KB-R7943. Am J Physiol Heart Circ Physiol 284: H903-H910, 2003.
19. 2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther 298: 249-256, 2001.
20. 2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury. Eur J Pharmacol 478: 187-198, 2003.
21. Requena J. Calcium efflux from squid axons under constant sodium electrochemical gradient. J Gen Physiol 72: 443-470, 1978.
22. 2+ exchange inhibitors. Circ Res 91: 90-92, 2002.
23. 2+ exchange: molecular and pharmacological aspects. Circ Res 88: 864-876, 2001.
24. 2+ exchanger, on myocardial ischemia-reperfusion injuries. Eur J Pharmacol 458: 155-162, 2003.
25. Tanaka H, Nishimaru K, Aikawa T, Hirayama W, Tanaka Y, and Shigenobu K. Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Br J Pharmacol 135: 1096-1100, 2002.
26. 2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol 119: 555-563, 1996.