3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 4.1 Side Chain Ester Derivatives of Mevinolin

Journal of Medicinal Chemistry

Volumn 29, Issue 5, 1986, Pages 849-852

  Hoffman, W F ^a   Alberts, A W ^b   Willard, A K ^c   Anderson, P S ^c   Smith, R L ^c   Chen, J S ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Rahway ^*  (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A C 14; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOCAPROIC ACID 1,2,3,7,8,8A HEXAHYDRO 3,7 DIMETHYL 8 [2 (TETRAHYDRO 4 HYDROXY 6 OXO 2H PYRAN 2 YL)ETHYL] 1 NAPHTHYL ESTER; MEVINOLIN; MEVINOLIN DERIVATIVE; NEW DRUG; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; DRUG ANALYSIS; DRUG COMPARISON; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; LIVER; NONHUMAN; PRELIMINARY COMMUNICATION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; NAPHTHALENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0022486908     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00155a040     Document Type: Article

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