Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2- azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 12, 2005, Pages 4085-4091

  Mojarrad, Javid S ^a,b   Vo, Dean ^a   Velázquez, Carlos ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,4 Dihydropyridines; Calcium channel antagonists; Dihalocarbenes

Indexed keywords

CALCIUM CHANNEL; CARBENOID; CARBOXYLIC ACID DERIVATIVE; ETHYL 7,7 DIBROMO 3 METHYL 5 (2 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; ISOBUTYL 7,7 DIBROMO 3 METHYL 5 (2 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; ISOPROPYL 7,7 DIBROMO 3 METHYL 5 (2 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; METHYL 7,7 DIBROMO 3 METHYL 5 (2 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; METHYL 7,7 DIBROMO 3 METHYL 5 (3 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; METHYL 7,7 DICHLORO 3 METHYL 5 (2 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; METHYL 7,7 DICHLORO 3 METHYL 5 (3 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; NIFEDIPINE; TERT BUTYL 7,7 DIBROMO 3 METHYL 5 (2 NITROPHENYL) 2 AZABICYCLO[4.1.0]HEPT 3 ENE 4 CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; IC 50; ILEUM; IN VITRO STUDY; INOTROPISM; NONHUMAN; REACTION ANALYSIS; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESTERS; GUINEA PIGS; HEART ATRIA; ILEUM; INHIBITORY CONCENTRATION 50; MUSCLE CONTRACTION; MUSCLE, SMOOTH; STRUCTURE-ACTIVITY RELATIONSHIP;

CAVIA PORCELLUS; SUS SCROFA;

EID: 19444385974     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.047     Document Type: Article

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