Syntheses, Calcium Channel Agonist-Antagonist Modulation Activities, and Nitric Oxide Release Studies of Nitrooxyalkyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl) pyridine-5-carboxylate Racemates, Enantiomers, and Diastereomers

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 254-261

  Shan, Rudong ^a   Velazquez, Carlos ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 2 NITROOXYETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BANZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; 2 (3,5 DINITROPHENYLCARBAMOYL) 2 (METHOXYCARBONYL)ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; 2 METHYL 2 NITROOXYETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; 2 NITROOXYETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; 3 NITROOXYPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; 4 (2,1,3 BENZOOXADIAZOL 4 YL) 1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 3 PYRIDINECARBOXYLIC ACID ISOPROPYL ESTER; 4 NITROOXYBUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; CARBOXYLIC ACID DERIVATIVE; CYSTEAMINE DERIVATIVE; ESTER; ISOPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2,1,3 BENZOXADIAZOL 4 YL)PYRIDINE 5 CARBOXYLATE; NITRIC OXIDE; NITRIC OXIDE DONOR; PYRIDINE DERIVATIVE; THIOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARDIOSELECTIVITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; GUINEA PIG; HEART; HEART LEFT ATRIUM; IC 50; ILEUM; IN VITRO STUDY; INOTROPISM; INTESTINE CONTRACTION; INTESTINE MUSCLE; NONHUMAN; RACEMIC MIXTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; GUINEA PIGS; HEART; ILEUM; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCARDIUM; NITRATES; NITRIC OXIDE; NITRIC OXIDE DONORS; OXADIAZOLES; STEREOISOMERISM; STIMULATION, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0346731230     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030333h     Document Type: Article

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