Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl- 3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate enantiomers

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 955-961

  Shan, Rudong ^a   Howlett, Susan E ^b   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 NITROOXYETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 (2 TRIFLUOROMETHYLPHENYL)PYRIDINE 5 CARBOXYLATE; ACETYLCYSTEINE; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; ESTER; GLYCEROL NITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CARDIOSELECTIVITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; FEMALE; GUINEA PIG; HEART MUSCLE CELL; IN VITRO STUDY; INTESTINE MUSCLE; MALE; NONHUMAN; RACEMIC MIXTURE; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP;

ANIMALS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; FEMALE; GUINEA PIGS; ILEUM; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE, SMOOTH; MYOCARDIUM; NICOTINIC ACIDS; NITRIC OXIDE; PATCH-CLAMP TECHNIQUES; PYRIDINES; STEREOISOMERISM;

EID: 0037075122     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010394k     Document Type: Article

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