Biophotonic imaging in HO-1.luc transgenic mice: Real-time demonstration of gender-specific chloroform induced renal toxicity

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 574, Issue 1-2 SPEC. ISS., 2005, Pages 67-75

  Weir, Lucinda R ^a   Schenck, Emanuel ^a,b   Meakin, Jackie ^a   McClure, Fiona ^a   Driver, Roy ^a   Walker, Sarah ^a   Lynch, Anthony M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Biophotonics; Chloroform; Haem oxygenase 1; Oxidative stress; Predictive toxicology; Transgenic mouse promoter reporter models

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CHLOROFORM; CHOLESTEROL; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; LUCIFERASE; SUPEROXIDE DISMUTASE; TESTOSTERONE; UREA;

ANDROGEN THERAPY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; BIOPHOTON IMAGING; CLINICAL CHEMISTRY; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC PROCEDURE; FEMALE; GENDER; GENE EXPRESSION; IMAGE ANALYSIS; INTERMETHOD COMPARISON; MALE; MICROSCOPY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SEX DIFFERENCE; TIME SERIES ANALYSIS; TOXICITY TESTING; TRANSGENIC MOUSE;

ANIMALS; BODY WEIGHT; CHLOROFORM; COMPUTER SYSTEMS; DIAGNOSTIC IMAGING; DRINKING; EATING; FEMALE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; KIDNEY; LIVER; LUCIFERASES; LUMINESCENT MEASUREMENTS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; SEX CHARACTERISTICS; TOXICITY TESTS;

ANIMALIA; MUS MUSCULUS;

EID: 19444378772     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.01.023     Document Type: Conference Paper

References (15)

1. W. Zhang, J.Q. Feng, S.E. Harris, P.R. Contag, D.K. Stevenson, and C.H. Contag Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression Transgenic Res. 10 2001 423 434
2. A. Agarwal, and H.S. Nick Renal response to tissue injury: lessons from heme oxygenase-1 gene ablation and expression J. Am. Soc. Nephrol. 11 2000 965 973
3. R. Baliga, N. Ueda, P.D. Walker, and S.V. Shah Oxidant mechanisms in toxic acute renal failure Drug Metab. Rev. 31 1999 971 997
4. F. Caballero, R. Meiss, A. Gimenez, A. Batlle, and E. Vazquez Immunohistochemicla analysis of heme-oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis Int. J. Exp. Path. 85 2004 213 221
5. R.S. Goldstein Toxic responses of the kidney C.D. Klaassen Cassarett and Doull's Toxicology: The Basic Science of Poisons 1996 McGraw Hill 432 433
6. R.J. Golden, S.E. Holm, D.E. Robinson, P.H. Julkunen, and E.A. Reese Chloroform mode of action: implications for cancer risk assessment Regul. Toxicol. Pharmacol. 26 1997 142 155
7. S.L. Rosenthal A review of the mutagenicity of chloroform Environ. Mol. Mutagen. 10 1987 211 226
8. E.J. Beddowes, S.P. Faux, and J.K. Chipman Chloroform, carbon tetrachloride and glutathione depletion induce secondary genotoxicity in liver cells via oxidative stress Toxicology 187 2003 101 115
9. J.H. Smith, and J.B. Hook Mechanism of chloroform toxicity. III. Renal and hepatic microsomal metabolism of chloroform in mice Toxicol. Appl. Pharmacol. 73 1984 511 524
10. W. Zhang, P.R. Contag, A. Madan, D.K. Stevenson, and C.H. Contag Bioluminescence for biological sensing in living mammals Eke Delpy Oxygen Transport to Tissue XXI 1999 Kluwer Academic/Plenum Publishers New York
11. P.J. O'Brien, M.R. Slaughter, A. Swain, J.M. Birmingham, R.W. Greenhill, F. Elcock, and P.J. Bugelski Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system Hum. Exp. Toxicol. 19 2000 277 283
12. M.R. Slaughter, and P.J. O'Brien Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase Clin. Biochem. 33 2000 525 534
13. A.M. Lynch, L.W. Weir, E. Schenck, J. Meakin, F. McClure, R. Driver, Biophotonic imaging in HO-1.luc transgenic mice treated with cadmium chloride, Submitted for publication.
14. J.E. Clark, R. Forest, C.J. Green, and R. Motterlini Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress Biochem. J. 348 2000 615 619
15. K.T. Morgan, H. Ni, H.R. Brown, L. Yoon, C.W. Qualls Jr., L.M. Crosby, R. Reynolds, B. Gaskill, S.P. Anderson, T.B. Kepler, T. Brainard, N. Liv, M. Easton, C. Merrill, D. Creech, D. Sprenger, G. Conner, P.R. Johnson, T. Fox, M. Sartor, E. Richard, S. Kuruvilla, W. Casey, and G. Benavides Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells Toxicol. Pathol. 30 2002 435 451