Small molecule microarrays: From proteins to mammalian cells - Are we there yet?

Trends in Biotechnology

Volumn 23, Issue 6, 2005, Pages 271-274

  Chiosis, Gabriela ^a   Brodsky, Jeffrey L ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOTECHNOLOGY; CELLS; POLYMERS;

BIODEGRADABLE POLYMERS; MAMMALIAN CELLS; SMALL MOLECULE MICROARRAYS (SMM);

PROTEINS;

POLYMER; PROTEIN; RAPAMYCIN; RECOMBINANT PROTEIN; SMALL MOLECULE TRANSPORT AGENT;

BIODEGRADABILITY; DNA MICROARRAY; HIGH THROUGHPUT SCREENING; HUMAN; MAMMAL CELL; MEDICAL TECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

MAMMALIA;

EID: 19444376044     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2005.03.011     Document Type: Short Survey

References (14)

1. G. MacBeath Printing small molecules as microarrays and detecting protein-ligand interactions en masse J. Am. Chem. Soc. 121 1999 7967 7968
2. M. Uttamchandani Small molecule microarrays: recent advances and applications Curr. Opin. Chem. Biol. 9 2005 1 10
3. P.J. Hergenrother Small molecule microarrays: covalent attachment and screening of alcohol-containing small molecules on glass slides J. Am. Chem. Soc. 122 2000 7849 7850
4. D. Barnes-Seeman Expanding the functional group dompatibility of small molecule microarrays: discovery of novel calmodulin ligands Angew. Chem. Int. Ed. Engl. 42 2003 2376 2379
5. M. Uttamchandani Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG J. Comb. Chem. 6 2004 862 868
6. L. Hackler Jr Development of chemically modified glass surfaces for nucleic acid, protein and small molecule microarrays Mol. Divers. 7 2003 25 36
7. M. Kohn Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays Angew. Chem. Int. Ed. Engl. 42 2003 5830 5834
8. W.S. Dillmore A photochemical method for patterning the immobilization of ligands and cells to self assembled monolayers Langmuir 20 2004 7223 7231
9. N. Kanoh Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein small molecule interactions Angew. Chem. Int. Ed. Engl. 42 2003 5584 5587
10. S. Li Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy Chem. Commun. (Camb) 5 2005 581 583
11. F.G. Kuruvilla Dissecting glucose signaling with diversity-oriented synthesis and small molecule microarrays Nature 416 2002 653 657
12. A.N. Koehler Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis J. Am. Chem. Soc. 125 2003 8420 8421
13. D.N. Gosalia Printing chemical libraries on microarrays for fluid phase nanoliter reactions Proc. Natl. Acad. Sci. U. S. A. 100 2003 8721 8726
14. S.N. Bailey Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens Proc. Natl. Acad. Sci. U. S. A. 101 2004 16144 16148