Adenovirus-mediated atrial natriuretic protein expression in the lung protects rats from hypoxia-induced pulmonary hypertension

Human Gene Therapy

Volumn 12, Issue 5, 2001, Pages 503-513

  Louzier, V ^a,b   Eddahibi, S ^a   Raffestin, B ^a,c   Deprez I ^a,b   Adam, M ^b   Levame, M ^a   Eloit, M ^b   Adnot, S ^a  

^a INSERM   (France)

^b Ecole Nationale Véérinaire d'Alfort   (France)

^c HÔPITAL AMBROISE PARÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; COMPLEMENTARY DNA; PHENYLEPHRINE;

ADENOVIRUS 5; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE THERAPY; GENE TRANSFER; HEART PROTECTION; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; IMMUNOREACTIVITY; NONHUMAN; NUCLEOTIDE REPEAT; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; ROUS SARCOMA ONCOVIRUS; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALIA; HUMAN ADENOVIRUS TYPE 5; ONCOVIRINAE; ROUS SARCOMA VIRUS;

EID: 0035937311     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303401300042401     Document Type: Article

References (34)

1. Atrial natriuretic peptide concentrations and pulmonary hemodynamics in patients with pulmonary artery hypertension
2. Atrial natriuretic factor attenuates the pulmonary pressor response to hypoxia
3. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia
4. Growth-regulatory properties of atrial natriuretic factor
5. Effects of natriuretic peptides on vascular smooth-muscle cells derived from different vascular beds
6. Characterization of ANF receptors in cultured renal cortical vascular smooth muscle cells
7. Acute response of nonhuman primates to airway delivery of an adenovirus vector containing the human CFTR cDNA
8. Induction of nitric oxide synthase activity in pulmonary arteries from normoxic and chronically hypoxic rats
9. Expression of biologically active atrial natriuretic factor following intra-hepatic injection of a replication-defective adenoviral vector in dogs
10. Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus-contaminating recombinant adenovirus stocks
11. Construction of a defective adenovirus vector expressing the pseudorabies virus glycoprotein gp50 and its use as a live vaccine
12. Ventricular weight in cardiac hypertrophy
13. Adenovirus-vector-mediated cytokine gene transfer to lung tissue
14. Characteristic of a human cell line transformed by DNA from human adenovirus type 5
15. Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells
16. Adenoviral mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats
17. Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia
18. Spontaneous in vitro release of alveolar macrophages cytokines after the intratracheal instillation of bleomycin in rats; Characterisation and kinetic studies
19. Cardiopulmonary responses to chronic hypoxia in transgenic mice that overexpress ANP
20. Down regulation of pulmonary atrial peptide receptors in rats exposed to chronic hypoxia
21. Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice
22. Inhibition by atrial natriuretic peptide of endothelin-1-stimulated proliferation of vascular smooth-muscle cells
23. Endothelin and endothelin antagonists: Potential role in cardiovascular and renal disease
24. Adenovirus-mediated lung VEGF overexpression protects against hypoxic pulmonary hypertension in rats
25. C-type natriuretic peptide inhibits growth factor-dependent DNA synthesis in smooth muscle cells
26. Rat pulmonary circulation after chronic hypoxia: Hemodynamic and structural features
27. Synthesis and secretion of ANF during chronic hypoxia, a study in the conscious instrumented rat
28. Pulmonary vasodilatory action of endogenous atrial natriuretic factor in rats with hypoxic pulmonary hypertension: Effect of monoclonal atrial natriuretic factor antibody
29. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vector
30. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues
31. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle
32. Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia
33. Effect of endothelin, angiotensin II and ANP on proliferation of vascular smooth muscle cells and cardiomyocytes
34. Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung