Towards a fully-synthetic substitute of alginate: Development of a new process using thermal gelation and chemical cross-linking

Biomaterials

Volumn 25, Issue 21, 2004, Pages 5115-5124

  Cellesi, Francesco ^a,b   Tirelli, Nicola ^a,b   Hubbell, Jeffrey A ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ETH ZURICH   (Switzerland)

Author keywords

Cell encapsulation; Michael type addition; Tetronics; Thermosensitive polymers

Indexed keywords

COPOLYMERS; CROSSLINKING; GELATION; POLYETHYLENE GLYCOLS; REACTION KINETICS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

ALGINATE; CHEMICAL MECHANISMS;

BIOMATERIALS;

ALGINIC ACID; CALCIUM ALGINATE;

ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; CROSS LINKING; DEVICE; DIFFUSION; ENCAPSULATION; FIBROBLAST CULTURE; GEL; GELATION; HUMAN; HUMAN CELL; MACROMOLECULE; PRECURSOR; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; SKIN FIBROBLAST; SYNTHESIS; THERMAL EXPOSURE;

ACRYLATES; ALGINATES; BIOCOMPATIBLE MATERIALS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CROSS-LINKING REAGENTS; FIBROBLASTS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGELS; MATERIALS TESTING; PHASE TRANSITION; POLYETHYLENE GLYCOLS; POLYMERS; PROPYLENE GLYCOLS; SULFHYDRYL COMPOUNDS; TEMPERATURE;

EID: 1942486842     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2003.12.015     Document Type: Article

References (21)

1. Soon-Shiong P. Treatment of type I diabetes using encapsulated islets. Adv Drug Delivery Rev. 35:1999;259-270.
2. Uludag H., De Vos P., Tresco P.A. Technology of mammalian cell encapsulation. Adv Drug Delivery Rev. 42:2000;29-64.
3. Stange J., Mitzner S. Hepatocyte encapsulation - initial intentions and new aspects for its use in bioartificial liver support. Int J Artif Organs. 19:1996;45-48.
4. Legallais C., David B., Dore E. Bioartificial livers (BAL). current technological aspects and future developments J Membr Sci. 181:2001;81-95.
5. Chia S.M., Leong K.W., Li J., Xu X., Zeng K.Y., Er P.N., Gao S.J., Yu H. Hepatocyte encapsulation for enhanced cellular functions. Tissue Eng. 6:2000;481-495.
6. Park J.K., Chang H.N. Microencapsulation of microbial cells. Biotechnol Adv. 18:2000;303-319.
7. Serp D., Cantana E., Heinzen C., von Stockar U., Marison I.W. Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol Bioeng. 70:2000;41-53.
8. Brandenberger H.R., Widmer F. Immobilization of highly concentrated cell suspensions using the laminar jet breakup technique. Biotechnol Prog. 15:1999;366-372.
9. Cellesi F., Tirelli N., Hubbell J.A. Materials for cell encapsulation via a new tandem approach combining reverse thermal gelation and covalent crosslinking. Macromol Chem Phys. 203:2002;1466-1472.
10. Perreur C, Habas JP, Francois J, Peyrelasse J, Lapp A. Determination of the structure of the organized phase of the block copolymer PEO-PPO-PEO in aqueous solutions under flow by small-angle neutron scattering. Phys Rev E 2002; 65:art. no.-041802.
11. Perreur C, Habas JP, Peyrelasse J, Francois J, Lapp A. Rheological and small-angle neutron scattering studies of aqueous solutions of branched PEO-PPO-PEO copolymers. Phys Rev E 2001; 6303:art. no.-031505.
12. Spancake C.W., Kildsig D.O., Mitra A.K. Thermorheologic properties of aqueous-solutions and gels of tetronic 1508. Pharm Res. 8:1991;345-349.
13. Napoli A., Tirelli N., Kilcher G., Hubbell J.A. New synthetic methodologies for amphiphilic multiblock copolymers of ethylene glycol and propylene sulfide. Macromolecules. 34:2001;8913-8917.
14. Lutolf M.P., Hubbell J.A. Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. Biomacromolecules. 4:2003;713-722.
15. Lutolf M.P., Tirelli N., Cerritelli S., Cavalli L., Hubbell J.A. Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids. Bioconjugate Chem. 12:2001;1051-1056.
16. Elbert D.L., Pratt A.B., Lutolf M.P., Halstenberg S., Hubbell J.A. Protein delivery from materials formed by self-selective conjugate addition reactions. J Controlled Rel. 76:2001;11-25.
17. Eyer P., Worek F., Kiderlen D., Sinko G., Stuglin A., Simeon-Rudolf V., Reiner E. Molar absorption coefficients for the reduced Ellman reagent. reassessment Anal Biochem. 312:2003;224-227.
18. Crank J. The mathematics of diffusion. 1994;Clarendon Press, Oxford.
19. Burke M.D., Park J.O., Srinivasarao M., Khan S.A. Diffusion of macromolecules in polymer solutions and gels. a laser scanning confocal microscopy study Macromolecules. 33:2000;7500-7507.
20. Pluen A., Netti P.A., Jain R.K., Berk D.A. Diffusion of macromolecules in agarose gels. comparison of linear and globular configurations Biophys J. 77:1999;542-552.
21. Li R.H., Altreuter D.H., Gentile F.T. Transport characterization of hydrogel matrices for cell encapsulation. Biotechnol Bioeng. 50:1996;365-373.