-
2
-
-
0027441715
-
Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure
-
Fairbairn S.M., Page C.P., Lees P., Cunningham F.M. Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clin Exp Allergy. 23:1993;821-828.
-
(1993)
Clin Exp Allergy
, vol.23
, pp. 821-828
-
-
Fairbairn, S.M.1
Page, C.P.2
Lees, P.3
Cunningham, F.M.4
-
3
-
-
0024292261
-
Chronic small airway disease in the horse: Immunohistochemical evaluation of lungs with mild, moderate and severe lesions
-
Winder N.C., von Fellenberg R. Chronic small airway disease in the horse: immunohistochemical evaluation of lungs with mild, moderate and severe lesions. Vet Rec. 122:1988;181-183.
-
(1988)
Vet Rec
, vol.122
, pp. 181-183
-
-
Winder, N.C.1
Von Fellenberg, R.2
-
4
-
-
0027174616
-
Phenotypic analysis of peripheral blood and bronchoalveolar lavage fluid lymphocytes in control and chronic obstructive pulmonary disease affected horses, before and after 'natural (hay and straw) challenges'
-
McGorum B.C., Dixon P.M., Halliwell R.E. Phenotypic analysis of peripheral blood and bronchoalveolar lavage fluid lymphocytes in control and chronic obstructive pulmonary disease affected horses, before and after 'natural (hay and straw) challenges'. Vet Immunol Immunopathol. 36:1993;207-222.
-
(1993)
Vet Immunol Immunopathol
, vol.36
, pp. 207-222
-
-
McGorum, B.C.1
Dixon, P.M.2
Halliwell, R.E.3
-
5
-
-
0035888749
-
Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile
-
Lavoie J.P., Maghni K., Desnoyers M., Taha R., Martin J.G., Hamid Q.A. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am J Respir Crit Care Med. 164:2001;1410-1413.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 1410-1413
-
-
Lavoie, J.P.1
Maghni, K.2
Desnoyers, M.3
Taha, R.4
Martin, J.G.5
Hamid, Q.A.6
-
6
-
-
0029131749
-
Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils
-
Ottonello L., Morone M.P., Dapino P., Dallegri F. Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils. Clin Exp Immunol. 101:1995;502-506.
-
(1995)
Clin Exp Immunol
, vol.101
, pp. 502-506
-
-
Ottonello, L.1
Morone, M.P.2
Dapino, P.3
Dallegri, F.4
-
7
-
-
0030593745
-
Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro
-
Alves A.C., Pires A.L., Cruz H.N., Serra M.F., Diaz B.L., Cordeiro R.S., Lagente V., Martins M.A. Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro. Eur J Pharmacol. 312:1996;89-96.
-
(1996)
Eur J Pharmacol
, vol.312
, pp. 89-96
-
-
Alves, A.C.1
Pires, A.L.2
Cruz, H.N.3
Serra, M.F.4
Diaz, B.L.5
Cordeiro, R.S.6
Lagente, V.7
Martins, M.A.8
-
8
-
-
0030876492
-
Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study
-
Gantner F., Tenor H., Gekeler V., Schudt C., Wendel A., Hatzelmann A. Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study. J Allergy Clin Immunol. 100:1997;527-535.
-
(1997)
J Allergy Clin Immunol
, vol.100
, pp. 527-535
-
-
Gantner, F.1
Tenor, H.2
Gekeler, V.3
Schudt, C.4
Wendel, A.5
Hatzelmann, A.6
-
9
-
-
0035882756
-
Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cells
-
Kanda N., Watanabe S. Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cells. Biochem Pharmacol. 62:2001;495-507.
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 495-507
-
-
Kanda, N.1
Watanabe, S.2
-
10
-
-
0029146718
-
Diversity in cyclic nucleotide phosphodiesterase isoenzyme families
-
Manganiello V.C., Murata T., Taira M., Belfrage P., Degerman E. Diversity in cyclic nucleotide phosphodiesterase isoenzyme families. Arch Biochem Biophys. 322:1995;1-13.
-
(1995)
Arch Biochem Biophys
, vol.322
, pp. 1-13
-
-
Manganiello, V.C.1
Murata, T.2
Taira, M.3
Belfrage, P.4
Degerman, E.5
-
11
-
-
0034009080
-
Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
-
Soderling S.H., Beavo J.A. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol. 12:2000;174-179.
-
(2000)
Curr Opin Cell Biol
, vol.12
, pp. 174-179
-
-
Soderling, S.H.1
Beavo, J.A.2
-
12
-
-
0034724177
-
Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
-
Fawcett L., Baxendale R., Stacey P., McGrouther C., Harrow I., Soderling S., Hetman J., Beavo J.A., Phillips S.C. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA. 97:2000;3702-3707.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3702-3707
-
-
Fawcett, L.1
Baxendale, R.2
Stacey, P.3
McGrouther, C.4
Harrow, I.5
Soderling, S.6
Hetman, J.7
Beavo, J.A.8
Phillips, S.C.9
-
13
-
-
25344436173
-
Intracellular enzyme profiles of equine lymphocytes isolated from normal horses and horses with heaves - An asthma-like syndrome
-
Rickards K.J., Page C.P., Hamblin A.S., Goode N.T., Cunningham F.M. Intracellular enzyme profiles of equine lymphocytes isolated from normal horses and horses with heaves - an asthma-like syndrome. Eur Respir J. 20:2002;511s.
-
(2002)
Eur Respir J
, vol.20
-
-
Rickards, K.J.1
Page, C.P.2
Hamblin, A.S.3
Goode, N.T.4
Cunningham, F.M.5
-
14
-
-
0029148807
-
Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes
-
Tenor H., Staniciu L., Schudt C., Hatzelmann A., Wendel A., Djukanovic R., Church M.K., Shute J.K. Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes. Clin Exp Allergy. 25:1995;616-624.
-
(1995)
Clin Exp Allergy
, vol.25
, pp. 616-624
-
-
Tenor, H.1
Staniciu, L.2
Schudt, C.3
Hatzelmann, A.4
Wendel, A.5
Djukanovic, R.6
Church, M.K.7
Shute, J.K.8
-
16
-
-
0033737479
-
A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects
-
Landells L.J., Spina D., Souness J.E., O'Connor B.J., Page C.P. A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects. Pulm Pharmacol Ther. 13:2000;231-239.
-
(2000)
Pulm Pharmacol Ther
, vol.13
, pp. 231-239
-
-
Landells, L.J.1
Spina, D.2
Souness, J.E.3
O'Connor, B.J.4
Page, C.P.5
-
17
-
-
0027537739
-
Differential inhibitor effects on cyclic adenosine monophosphate- phosphodiesterase isoforms in atopic and normal leukocytes [see comments]
-
Chan S.C., Hanifin J.M. Differential inhibitor effects on cyclic adenosine monophosphate-phosphodiesterase isoforms in atopic and normal leukocytes [see comments]. J Lab Clin Med. 121:1993;44-51.
-
(1993)
J Lab Clin Med
, vol.121
, pp. 44-51
-
-
Chan, S.C.1
Hanifin, J.M.2
-
18
-
-
0031777191
-
Cyclic adenosine monophosphate phosphodiesterase activity in peripheral blood mononuclear leucocytes from patients with atopic dermatitis: Correlation with respiratory atopy
-
Sawai T., Ikai K., Uehara M. Cyclic adenosine monophosphate phosphodiesterase activity in peripheral blood mononuclear leucocytes from patients with atopic dermatitis: correlation with respiratory atopy. Br J Dermatol. 138:1998;846-848.
-
(1998)
Br J Dermatol
, vol.138
, pp. 846-848
-
-
Sawai, T.1
Ikai, K.2
Uehara, M.3
-
19
-
-
0029560498
-
Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis
-
Banner K.H., Roberts N.M., Page C.P. Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis. Br J Pharmacol. 116:1995;3169-3174.
-
(1995)
Br J Pharmacol
, vol.116
, pp. 3169-3174
-
-
Banner, K.H.1
Roberts, N.M.2
Page, C.P.3
-
20
-
-
0032167747
-
Effects of theophylline on lymphocyte phosphodiesterase activity
-
Tohda Y., Nahkahara H., Kubo H., Ohkawa K., Fukuoka M., Nakajima S. Effects of theophylline on lymphocyte phosphodiesterase activity. Gen Pharmacol. 31:1998;409-413.
-
(1998)
Gen Pharmacol
, vol.31
, pp. 409-413
-
-
Tohda, Y.1
Nahkahara, H.2
Kubo, H.3
Ohkawa, K.4
Fukuoka, M.5
Nakajima, S.6
-
21
-
-
0028791194
-
Exacerbations of asthma without sputum eosinophilia
-
Turner M.O., Hussack P., Sears M.R., Dolovich J., Hargreave F.E. Exacerbations of asthma without sputum eosinophilia. Thorax. 50:1995;1057-1061.
-
(1995)
Thorax
, vol.50
, pp. 1057-1061
-
-
Turner, M.O.1
Hussack, P.2
Sears, M.R.3
Dolovich, J.4
Hargreave, F.E.5
-
22
-
-
0031888467
-
Bronchial neutrophilia in patients with noninfectious status asthmaticus
-
Lamblin C., Gosset P., Tillie-Leblond I., Saulnier F., Marquette C.H., Wallaert B., Tonnel A.B. Bronchial neutrophilia in patients with noninfectious status asthmaticus. Am J Respir Crit Care Med. 157:1998;394-402.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 394-402
-
-
Lamblin, C.1
Gosset, P.2
Tillie-Leblond, I.3
Saulnier, F.4
Marquette, C.H.5
Wallaert, B.6
Tonnel, A.B.7
-
23
-
-
0029278910
-
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation
-
Fahy J.V., Kim K.W., Liu J., Boushey H.A. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol. 95:1995;843-852.
-
(1995)
J Allergy Clin Immunol
, vol.95
, pp. 843-852
-
-
Fahy, J.V.1
Kim, K.W.2
Liu, J.3
Boushey, H.A.4
-
24
-
-
0028048109
-
Report of the first international workshop on leucocyte antigens, Cambridge, UK, July 1991
-
Kydd J., Antczak D., Allen W., Barbis D., Butcher G., Davis W., Duffus W., Edgington N., Grunig G., Holmes M., Lunn D., McCulloch J., O'Brien A., Perryman L., Tavernor A., Williamson S., Zhang C. Report of the first international workshop on leucocyte antigens, Cambridge, UK, July 1991. Vet Immunol Immunopathol. 42:1994;3-60.
-
(1994)
Vet Immunol Immunopathol
, vol.42
, pp. 3-60
-
-
Kydd, J.1
Antczak, D.2
Allen, W.3
Barbis, D.4
Butcher, G.5
Davis, W.6
Duffus, W.7
Edgington, N.8
Grunig, G.9
Holmes, M.10
Lunn, D.11
McCulloch, J.12
O'Brien, A.13
Perryman, L.14
Tavernor, A.15
Williamson, S.16
Zhang, C.17
-
25
-
-
0034739696
-
Phosphodiesterase activity in neutrophils from horses with chronic obstructive pulmonary disease
-
Rickards K., Page C., Lees P., Cunningham F. Phosphodiesterase activity in neutrophils from horses with chronic obstructive pulmonary disease. Vet Immunol Immunopathol. 76:2000;319-330.
-
(2000)
Vet Immunol Immunopathol
, vol.76
, pp. 319-330
-
-
Rickards, K.1
Page, C.2
Lees, P.3
Cunningham, F.4
-
27
-
-
0000021687
-
Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - Their potential utility in the therapy of asthma
-
Nicholson C.D., Shahid M. Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - their potential utility in the therapy of asthma. Pulm Pharmacol. 6:1993;101-117.
-
(1993)
Pulm Pharmacol
, vol.6
, pp. 101-117
-
-
Nicholson, C.D.1
Shahid, M.2
-
28
-
-
0029900395
-
Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects
-
Tenor H., Hatzelmann A., Church M.K., Schudt C., Shute J.K. Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br J Pharmacol. 118:1996;1727-1735.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1727-1735
-
-
Tenor, H.1
Hatzelmann, A.2
Church, M.K.3
Schudt, C.4
Shute, J.K.5
-
29
-
-
0036371544
-
Antigen challenge increases adherence of circulating neutrophils in horses with chronic obstructive pulmonary disease
-
Marr K.A., Lees P., Cunningham F.M. Antigen challenge increases adherence of circulating neutrophils in horses with chronic obstructive pulmonary disease. Equine Vet J. 34:2002;65-70.
-
(2002)
Equine Vet J
, vol.34
, pp. 65-70
-
-
Marr, K.A.1
Lees, P.2
Cunningham, F.M.3
-
30
-
-
0031671485
-
Equine peripheral blood mononuclear cells proliferate in response to tetanus toxoid antigen
-
McKelvie J., Little S., Foster A.P., Cunningham F.M., Hamblin A. Equine peripheral blood mononuclear cells proliferate in response to tetanus toxoid antigen. Res Vet Sci. 65:1998;91-92.
-
(1998)
Res Vet Sci
, vol.65
, pp. 91-92
-
-
McKelvie, J.1
Little, S.2
Foster, A.P.3
Cunningham, F.M.4
Hamblin, A.5
-
31
-
-
0020410475
-
Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: A possible mechanism for cyclic AMP-agonist hyporesponsiveness
-
Grewe S.R., Chan S.C., Hanifin J.M. Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness. J Allergy Clin Immunol. 70:1982;452-457.
-
(1982)
J Allergy Clin Immunol
, vol.70
, pp. 452-457
-
-
Grewe, S.R.1
Chan, S.C.2
Hanifin, J.M.3
-
32
-
-
0026650380
-
Synergistic effects of interleukin 4 and interferon-gamma on monocyte phosphodiesterase activity
-
Li S.H., Chan S.C., Toshitani A., Leung D.Y., Hanifin J.M. Synergistic effects of interleukin 4 and interferon-gamma on monocyte phosphodiesterase activity. J Invest Dermatol. 99:1992;65-70.
-
(1992)
J Invest Dermatol
, vol.99
, pp. 65-70
-
-
Li, S.H.1
Chan, S.C.2
Toshitani, A.3
Leung, D.Y.4
Hanifin, J.M.5
-
33
-
-
0030075351
-
Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B
-
Manning C.D., McLaughlin M.M., Livi G.P., Cieslinski L.B., Torphy T.J., Barnette M.S. Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B. J Pharmacol Exp Ther. 276:1996;810-818.
-
(1996)
J Pharmacol Exp Ther
, vol.276
, pp. 810-818
-
-
Manning, C.D.1
McLaughlin, M.M.2
Livi, G.P.3
Cieslinski, L.B.4
Torphy, T.J.5
Barnette, M.S.6
-
34
-
-
0031028090
-
Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant
-
Erdogan S., Houslay M.D. Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant. Biochem J. 321:1997;165-175.
-
(1997)
Biochem J
, vol.321
, pp. 165-175
-
-
Erdogan, S.1
Houslay, M.D.2
-
35
-
-
0030725505
-
Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1
-
Yu J., Wolda S.L., Frazier A.L., Florio V.A., Martins T.J., Snyder P.B., Harris E.A., McCaw K.N., Farrell C.A., Steiner B., Bentley J.K., Beavo J.A., Ferguson K., Gelinas R. Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. Cell Signal. 9:1997;519-529.
-
(1997)
Cell Signal
, vol.9
, pp. 519-529
-
-
Yu, J.1
Wolda, S.L.2
Frazier, A.L.3
Florio, V.A.4
Martins, T.J.5
Snyder, P.B.6
Harris, E.A.7
McCaw, K.N.8
Farrell, C.A.9
Steiner, B.10
Bentley, J.K.11
Beavo, J.A.12
Ferguson, K.13
Gelinas, R.14
-
36
-
-
0034944944
-
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects
-
Landells L.J., Szilagy C.M., Jones N.A., Banner K.H., Allen J.M., Doherty A., O'Connor B.J., Spina D., Page C.P. Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects. Br J Pharmacol. 133:2001;722-729.
-
(2001)
Br J Pharmacol
, vol.133
, pp. 722-729
-
-
Landells, L.J.1
Szilagy, C.M.2
Jones, N.A.3
Banner, K.H.4
Allen, J.M.5
Doherty, A.6
O'Connor, B.J.7
Spina, D.8
Page, C.P.9
-
37
-
-
0029833842
-
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: Role in regulating proliferation and the biosynthesis of interleukin-2
-
Giembycz M.A., Corrigan C.J., Seybold J., Newton R., Barnes P.J. Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. Br J Pharmacol. 118:1996;1945-1958.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1945-1958
-
-
Giembycz, M.A.1
Corrigan, C.J.2
Seybold, J.3
Newton, R.4
Barnes, P.J.5
-
38
-
-
0022543723
-
Monocyte localization of elevated cAMP phosphodiesterase activity in atopic dermatitis
-
Holden C.A., Chan S.C., Hanifin J.M. Monocyte localization of elevated cAMP phosphodiesterase activity in atopic dermatitis. J Invest Dermatol. 87:1986;372-376.
-
(1986)
J Invest Dermatol
, vol.87
, pp. 372-376
-
-
Holden, C.A.1
Chan, S.C.2
Hanifin, J.M.3
-
39
-
-
0030460944
-
Characterisation of the isoenzymes of cyclic nucleotide phosphodiesterases in human platelets and the effects of E4021
-
Ito M., Nishikawa M., Fujioka M., Miyahara M., Isaka N., Shiku H., Nakano T. Characterisation of the isoenzymes of cyclic nucleotide phosphodiesterases in human platelets and the effects of E4021. Cell Signal. 8:1996;575-581.
-
(1996)
Cell Signal
, vol.8
, pp. 575-581
-
-
Ito, M.1
Nishikawa, M.2
Fujioka, M.3
Miyahara, M.4
Isaka, N.5
Shiku, H.6
Nakano, T.7
-
40
-
-
1942531895
-
A PDE7 inhibitor, BRL 50481, acts synergistically with rolipram in the regulation of cytokine release from LPS-stimulated human monocytes and lung macrophages
-
Smith S.J., Barnes P.J., Barnette M.S., Giembycz M.A. A PDE7 inhibitor, BRL 50481, acts synergistically with rolipram in the regulation of cytokine release from LPS-stimulated human monocytes and lung macrophages. Am J Respir Crit Care Med. 167:2003;A216.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 216
-
-
Smith, S.J.1
Barnes, P.J.2
Barnette, M.S.3
Giembycz, M.A.4
-
41
-
-
0033737479
-
A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects
-
Landells L.J., Spina D., Souness J.E., O'Connor B.J., Page C.P. A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects. Pulm Pharmacol Ther. 13:2000;231-239.
-
(2000)
Pulm Pharmacol Ther
, vol.13
, pp. 231-239
-
-
Landells, L.J.1
Spina, D.2
Souness, J.E.3
O'Connor, B.J.4
Page, C.P.5
-
42
-
-
0035901502
-
MAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
-
Dodge K.L., Khouangsathiene S., Kapiloff M.S., Mouton R., Hill E.V., Houslay M.D., Langeberg L.K., Scott J.D. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. Embo J. 20:2001;1921-1930.
-
(2001)
Embo J
, vol.20
, pp. 1921-1930
-
-
Dodge, K.L.1
Khouangsathiene, S.2
Kapiloff, M.S.3
Mouton, R.4
Hill, E.V.5
Houslay, M.D.6
Langeberg, L.K.7
Scott, J.D.8
|