Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins

Biochemical and Biophysical Research Communications

Volumn 290, Issue 3, 2002, Pages 921-927

  Oda, Michael N ^a   Bielicki, John K ^a   Ho, Tamara T ^a   Rubin, Edward M ^a   Forte, Trudy M ^a   Berger, Trish ^b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

High density lipoproteins; Lecithin:cholesterol acyltransferase; Lipid peroxidation; Paraoxonase; Transgenic mice

Indexed keywords

ARYLDIALKYLPHOSPHATASE; ARYLESTERASE; COPPER ION; HIGH DENSITY LIPOPROTEIN; LIPID HYDROPEROXIDE; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; MASS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE; WILD TYPE;

MUS MUSCULUS;

EID: 0036293423     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6295     Document Type: Article

References (30)

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4. HDL, its enzymes and its potential to influence lipid peroxidation
5. Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein
6. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
7. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase
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9. Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus
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11. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
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13. Minimally oxidized LDL is a potent inhibitor of lecithin:cholesterol acyltransferase activity
14. Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity
15. Genetic transformation of mouse embryos by microinjection of purified DNA
16. Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities
17. Nondenaturing polyacrylamide gradient gel electrophoresis
18. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
19. Copper and gas-phase cigarette smoke inhibit plasma lecithin:cholesterol acyltransferase activity by different mechanisms
20. Characterization of proteoliposomes containing apoprotein A-I: A new substrate for the measurement of lecithin:cholesterol acyltransferase activity
21. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors
22. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
23. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
24. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
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26. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein
27. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein
28. HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
29. Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles