Role of spinal nitric oxide synthase-dependent processes in the initiation of the micturition hyperreflexia associated with cyclophosphamide-induced cystitis

Neuroscience

Volumn 125, Issue 3, 2004, Pages 663-670

  Lagos, P ^a,b   Ballejo, G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

BH4; c Fos NADPH d co localization; Ca2+ dependent NOS activity; Carbachol; CCh; CHAPS; Intrathecal NOS inhibitors; Lumbosacral spinal segments; Micturition threshold volume; nNOS immunoreactivity; Tetrahydrobiopterin

Indexed keywords

ARGININE; CALCIUM ION; CARBACHOL; CYCLOPHOSPHAMIDE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN C FOS; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; S METHYLTHIOCITRULLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER DISEASE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; HEMORRHAGIC CYSTITIS; HYPERREFLEXIA; IMMUNOCOMPETENT CELL; LUMBOSACRAL PLEXUS; MICTURITION DISORDER; NERVE CELL; NERVE POTENTIAL; NEUROTRANSMISSION; NITRERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; RAT; URINE VOLUME;

ANIMALS; CYCLOPHOSPHAMIDE; CYSTITIS; ENZYME INHIBITORS; FEMALE; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; MUSCLE, SMOOTH; NADPH DEHYDROGENASE; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PARASYMPATHETIC FIBERS, POSTGANGLIONIC; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; REFLEX, ABNORMAL; SPINAL CORD; URINARY BLADDER; URINATION; URINATION DISORDERS;

EID: 1942424846     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2003.10.048     Document Type: Article

References (34)

1. Alfieri A.B., Malave A., Cubeddu L.X. Nitric oxide synthases and cyclophosphamide-induced cystitis in rats. Naunyn Schmiedebergs Arch Pharmacol. 363:2001;353-357.
2. Araki I., De Groat W.C. Urinary excitatory synaptic currents in preganglionic neurons mediated by two distinct groups of interneurons in neonatal rat sacral parasympathetic nucleus. J Neurophysiol. 76:1996;215-226.
3. Bender A.T., Silvestein A.M., Demady D.R., Kanelakis K.C., Noguchi S., Pratt W.B., Osawa Y. Neuronal nitric oxide synthase is regulated by the hsp-90-based chaperone system in vivo. J Biol Chem. 274:1999;1472-1478.
4. Birder L.A., De Groat W.C. Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat. J Neurosci. 12:1992;4878-4889.
5. Birder L.A., Roppolo J.R., Erickson V.L., De Groat W.C. Increased c-fos expression in spinal lumbosacral projection neurons and preganglionic neurons after irritation of the lower urinary tract in the rat. Brain Res. 834:1999;55-65.
6. Callsen-Cencic P., Mense S. Expression of neuropeptides and nitric oxide synthase in neurons innervating the inflamed rat urinary bladder. J Auton Nerv Syst. 65:1997;33-44.
7. Callsen-Cencic P., Hoheisel U., Kaske A., Mense S., Tenschert S. The controversy about spinal neuronal nitric oxide synthase under which conditions is it up- or downregulated? Cell Tissue Res. 295:1999;183-194.
8. Coutinho S.V., Meller S.T., Gebhart G.F. Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors. Brain Res. 736:1996;7-15.
9. Coutinho S.V., Gebhart G.F. A role of spinal nitric oxide in mediating visceral hyperalgesia in the rat. Gastroenterology. 116:1999;1399-1408.
10. Cox P.J. Cyclophosphamide cystitis identification of acrolein as the causative agent. Biochem Pharmacol. 28:1979;2045-2049.
11. Furfine E.S., Harmon M.F., Paith J.E., Knowles R.G., Salter M., Kiff R.J., Duffy C., Hazelwood R., Oplinger J.A., Garvey E.P. Potent and selective inhibition of human nitric oxide synthases. J Biol Chem. 269:1994;26677-26683.
12. Gebhart G.F. Pathobiology of visceral pain molecular mechanisms and therapeutic implications: IV. Visceral afferent contributions to the pathobiology of visceral pain. Am J Physiol Gastrointest Liver Physiol. 278:(G834-):2000;838.
13. Gougis S., Prud'homme M.-J., Rampin O. Presence of the N-methyl-D-aspartic acid R1 glutamatergic receptor subunit in the lumbosacral spinal cord of male rats. Neurosci Lett. 323:2002;224-228.
14. Hamilton M.O., Papka R.E., O'Donoghue D.L., Vaidya A.M., Williams S.J., Poff C.R., McNeill D.L. Spinal projection neurons to the laterodorsal pontine tegmental nucleus relationship to preganglionic neurons and nitric oxide synthase. J Comp Neurol. 353:1995;1-8.
15. Ide Y., Maehara Y., Tsukahara S., Kitahata L.M., Collins J.G. The effects of an intrathecal NMDA antagonist (AP5) on the behavioral changes induced by colorectal inflammation with turpentine in rats. Life Sci. 60:1997;1359-1363.
16. Kakizaki H., De Groat W.C. Role of spinal nitric oxide in the facilitation of the micturition reflex by bladder irritation. J Urol. 155:1996;355-360.
17. Lantéri-Minet M., Isnardon P., de Pommery J., Menetrey D. Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins. Neuroscience. 55:1993;737-753.
18. 2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats. Eur J Pharmacol. 259:1994;129-135.
19. Levine L.A., Richie J.P. Urological complications of cyclophosphamide. J Urol. 141:1989;1063-1069.
20. Maggi C.A., Lecci A., Santicioli P., Del Bianco E., Giuliani S. Cyclophosphamide cystitis in rats involvement of capsaicin-sensitive primary afferents. J Auton Nerv Syst. 38:1992;201-208.
21. Meller S.T., Gebhart G.F. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain. 52:1993;127-136.
22. Miura A., Kawatani M., De Groat W.C. Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons evoked by stimulation of the dorsal commissure. J Neurophysiol. 89:2003;382-389.
23. Pandita R.J., Persson K., Andersson K.-E. Capsaicin-induced bladder overactivity and nociceptive behaviour in conscious rats involvement of spinal nitric oxide. J Auton Nerv Syst. 67:1997;184-191.
24. Rice A.S.C., McMahon S.B. Pre-emptive intrathecal administration of an NMDA receptor antagonist (AP-5) prevents hyper-reflexia in a model of persistent visceral pain. Pain. 57:1994;335-340.
25. Rice A.S.C. Topical spinal administration of a nitric oxide synthase inhibitor prevents the hyper-reflexia associated with a rat model of persistent visceral pain. Neurosci Lett. 187:1995;111-114.
26. Salter M., Knowles R.G., Moncada S. Widespread tissue species distribution and changes in activity of Ca-dependent and Ca-independent nitric oxide synthase. FEBS Lett. 291:1991;145-149.
27. Song Y., Zweier J.L., Xia Y. Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy. Am J Physiol Cell Physiol. 281:2001;C1819-1824.
28. Souza-Filho M.V.P., Lima M.V.A., Pompeu M.M.L., Ballejo G., Cunha F.Q., Ribeiro R.A. Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Am J Pathol. 150:1997;247-256.
29. Vincent S.R., Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience. 46:1992;755-784.
30. Vizzard M.A., Erdman S.L., De Groat W.C. Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation. J Comp Neurol. 370:1996;191-202.
31. Yaksh T.L., Hua X.-Y., Kalcheva I., Nozaki-Taguchi N., Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci USA. 96:1999;7680-7686.
32. Yoshimura N., De Groat W.C. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci. 19:1999;4644-4653.
33. Yoshiyama M., Roppolo J.R., De Groat W.C. Effects of LY215490, a competitive α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor antagonist, on the micturition reflex in the rat. J Pharmacol Exp Ther. 280:1997;894-904.
34. Woolf C.J. Excitability changes in central neurons following peripheral damage role of central sensitization in the pathogenesis of pain. Willis W.D. Jr. Hyperalgesia and allodynia. 1992;221-243 Raven Press, Ltd, New York.